Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines. Collectively these proteins are the key orchestrators of host defense and the response to tissue injury. There are currently 23 different interleukins (numbered from IL-1 to IL-23), although the full extent of the interleukin family will only become clear upon analysis of the human genome sequence. Most important, interleukins are central to the pathogenesis of a wide range of diseases that involve an immune com- nent, including such conditions as rheumatoid arthritis, multiple sclerosis, ulcerative colitis, psoriasis, and asthma. Interleukins have also been imp- cated in other conditions, including cancer, migraine, myocardial infarction, and depression. In essence, when cells are activated by interleukins, a program of gene expression is initiated in the target cell that alters the cell's phenotype, leading to enhanced immune reactivity, inflammation, and/or proliferation. Interleukins are therefore at the core of the cellular basis for many diseases. They are the subject of intense investigation by biomedical researchers and the targeting or use of interleukins in the clinic is proceeding apace. Approaches such as t- geting IL-4 in asthma or IL-1 in joint disease are being pursued, and it is likely that in the next 5-10 years a number of new therapies based on either inhib- ing or administering interleukins will be available.

From Romanticism to Critical Theory explores the philosophical origins of literary theory via the tradition of German philosophy that began with the Romantic reaction to Kant. It traces the continuation of the Romantic tradition of Novalis, Friedrich Schlegel and Schleiermacher, in Heidegger's approaches to art and thruth, and in the Critical Theory of Benjamin and Adorno.
Andrew Bowie argues, against many current assumptions, that the key aspect of literary theory is not the demonstration of how meaning can be deconstructed, but rather the relevation of how questions of language and literature change modern philosophical conceptions of thruth. He shows how the dialogue between literary theory, hermeneutics and analytical philosophy can profit from a re-examination of the understanding of language, thruth and literature in modern German philosophy.
From Romanticism to Critical Theory will provide a vital new introduction to central theoretical questions for students of philosophy, literature, German studies, cultural and social theory.

Andrew Bowie's book is the first introduction in English to present F W J Schelling as a major European philospher in his own right. Schelling and Modern European Philosophy, surveys the whole of Schelling's philosophical career, lucidly reconstructing his key arguments, particularly those against Hegel, and relating them to contemporary philosophical discussion. Dr Bowie traces how central ideas and conceptual strategies in the work of philosophers as diverse as Nietzsche, Heidegger, Derrida and Davidson relate closely to Schelling's often misunderstood philosophy and focuses on Schelling's work as an alternative to, and critique of aspects of Hegel's thinking.

Andrew Bowie's book is the first introduction in English to present F. W. J. Schelling as a major European philosopher in his own right. Schelling and Modern European Philosophy, surveys the whole of Schelling's philosophical career, lucidly reconstructing his key arguments, particularly those against Hegel, and relating them to contemporary philosophical discussion.
For anyone interested in German romanticism and the development of Continental philosophy, this is an invaluable source book. The cogent and subtle argument of this book fills a major gap in our understanding of modern philosophy, in which Schelling emerges as a key transitional figure.

Literary theory is now perceived by many as being in crisis because many of its dominant theoretical assumptions proving hard to sustain. This volume offers a view of literary theory, seeing it not as a product of the Franch assimilation of Saussurian linguistics and Russian Formalism into what we term "deconstruction", but rather as an essential part of modern philosophy which begins with the German Romantic reactions to Kant, the effects of which can be traced through to Heidegger, Benjamin and Adorno. Andrew Bowie argues that, contrary to many current assumptions, the central question in contemporary literary theory is really the question of truth. He begins by showing how Kant's and F.H Jacobi's reflection on grounding truth in modern philosophy form the background to the exploration of the relationship between literature and philosophy in early German Romanticism.

Andrew Bowie's book is the first introduction in English to present F W J Schelling as a major European philospher in his own right. Schelling and Modern European Philosophy, surveys the whole of Schelling's philosophical career, lucidly reconstructing his key arguments, particularly those against Hegel, and relating them to contemporary philosophical discussion. Dr Bowie traces how central ideas and conceptual strategies in the work of philosophers as diverse as Nietzsche, Heidegger, Derrida and Davidson relate closely to Schelling's often misunderstood philosophy and focuses on Schelling's work as an alternative to, and critique of aspects of Hegel's thinking.

Andrew Bowie's book is the first introduction in English to present F. W. J. Schelling as a major European philosopher in his own right. Schelling and Modern European Philosophy, surveys the whole of Schelling's philosophical career, lucidly reconstructing his key arguments, particularly those against Hegel, and relating them to contemporary philosophical discussion.
For anyone interested in German romanticism and the development of Continental philosophy, this is an invaluable source book. The cogent and subtle argument of this book fills a major gap in our understanding of modern philosophy, in which Schelling emerges as a key transitional figure.

Very Short Introductions: Brilliant, Sharp, Inspiring T.W. Adorno (1903-69) was a German philosopher and social and cultural theorist. His work has come to be seen as increasingly relevant to understanding the pathologies of contemporary society evident in today's climate emergency, the financial crash, the reappearance of fascism in many countries, and the growing instability of the world order. This Very Short Introduction covers Adorno's work and life, explaining his key philosophical concepts and the philosophical background and historical context of Adorno's thinking. Andrew Bowie shows how Adorno's exploration of why human reason can have irrational consequences led him to rethink basic concepts like 'nature', 'history', and 'freedom', offering alternatives to many ways of thinking about these concepts in contemporary philosophy. The book also examines Adorno's social theory, as well as his highly critical assessments of jazz and modern culture, which he considered threatened by the effects of modern capitalism. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines. Collectively these proteins are the key orchestrators of host defense and the response to tissue injury. There are currently 23 different interleukins (numbered from IL-1 to IL-23), although the full extent of the interleukin family will only become clear upon analysis of the human genome sequence. Most important, interleukins are central to the pathogenesis of a wide range of diseases that involve an immune com- nent, including such conditions as rheumatoid arthritis, multiple sclerosis, ulcerative colitis, psoriasis, and asthma. Interleukins have also been imp- cated in other conditions, including cancer, migraine, myocardial infarction, and depression. In essence, when cells are activated by interleukins, a program of gene expression is initiated in the target cell that alters the cell's phenotype, leading to enhanced immune reactivity, inflammation, and/or proliferation. Interleukins are therefore at the core of the cellular basis for many diseases. They are the subject of intense investigation by biomedical researchers and the targeting or use of interleukins in the clinic is proceeding apace. Approaches such as t- geting IL-4 in asthma or IL-1 in joint disease are being pursued, and it is likely that in the next 5-10 years a number of new therapies based on either inhib- ing or administering interleukins will be available.

The work of the German philosopher Manfred Frank has profoundly affected the direction of the contemporary debate in many areas of philosophy and literary theory. This present collection, first published in 1998, brings together some of his most important essays, on subjects as diverse as Schleiermacher's hermeneutics, the status of the literary text, and the response to the work of Derrida and Lacan. Frank shows how the discussions of subjectivity in recent literary theory fail to take account of important developments in German Idealist and Romantic philosophy. The prominence accorded language in literary theory and analytic philosophy, he claims, ignores key arguments inherited from Romantic hermeneutics, those which demonstrate that interpretation is an individual activity never finally governed by rules. Andrew Bowie's introduction situates Frank's work in the context of contemporary debates in philosophy and literary theory.

Schleiermacher's Hermeneutics and Criticism is the founding text of modern hermeneutics. Written as a method for the interpretation and textual criticism of the New Testament, it is remarkably relevant to contemporary theories of interpretation in literary theory and analytical philosophy. This volume offers the text in a new translation by Andrew Bowie, together with related writings on secular hermeneutics and language. An introduction places the texts in the context of Schleiermacher's philosophy as a whole.

New, completely revised and re-written edition. Offers a detailed but accessible account of the vital German philosophical tradition of thinking about art and the self. Looks at recent historical research and contemporary arguments in philosophy and theory in the humanities, following the path of German philosophy from Kant, via Fichte and Holderlin, the early Romantics, Schelling, Hegel, Schleiermacher, to Nietzsche. Develops the approaches to subjectivity, aesthetics, music and language in relation to new theoretical developments bridging the divide between the continental and analytical traditions of philosophy. The huge growth of interest in German philosophy as a resource for re-thinking both literary and cultural theory, and contemporary philosophy will make this an indispensable read -- .

On the History of Modern Philosophy is a transitional text in the history of European philosophy. It contains F.W.J. Schelling's survey of philosophy from Descartes to German idealism and argues that the Idealist project is ultimately doomed to failure. The lectures trace the path of philosophy from Descartes through Spinoza, Leibniz, Kant, Fichte, Jacobi, to Hegel, and include Schellings own work. The extensive critiques of Hegel prefigure many of the arguments to be found in Feuerbach, Kierkegaard, Marx, Nietzsche, Heidegger, and Derrida. This is the first English translation of On the History of Modern Philosophy. In his introduction Andrew Bowie sets the work in the context of Schelling's career and clarifies its philosophical issues. The translation will be of special interest to philosophers, intellectual historians, literary theorists, and theologians.

On the History of Modern Philosophy is a transitional text in the history of European philosophy. It contains F.W.J. Schelling's survey of philosophy from Descartes to German idealism and argues that the Idealist project is ultimately doomed to failure. The lectures trace the path of philosophy from Descartes through Spinoza, Leibniz, Kant, Fichte, Jacobi, to Hegel, and include Schellings own work. The extensive critiques of Hegel prefigure many of the arguments to be found in Feuerbach, Kierkegaard, Marx, Nietzsche, Heidegger, and Derrida. This is the first English translation of On the History of Modern Philosophy. In his introduction Andrew Bowie sets the work in the context of Schelling's career and clarifies its philosophical issues. The translation will be of special interest to philosophers, intellectual historians, literary theorists, and theologians.

Much of contemporary philosophy, especially in the analytical tradition, regards aesthetics as of lesser significance than epistemology, ethics, metaphysics, and the philosophy of language. Yet, in Aesthetic Dimensions of Modern Philosophy, Andrew Bowie explores the idea that art and aesthetics have crucial implications for those areas of philosophy. In the modern period, the growth of warranted scientific knowledge is accompanied both by heightened concern with epistemological scepticism and a new philosophical attention to art and the beauty of nature. This suggests that modernity involves problems concerning how human beings make sense of the world that go beyond questions of knowledge, and are reflected in the arts. The relationship of art to philosophy is explored in Montaigne, Descartes, Hume, Kant, Schelling, the early German Romantics, and Hegel. This book also considers Cassirer's and the hermeneutic tradition's exploration of close links between meaning in language and in art. The work of Karl Polanyi, Marx, Nietzsche, Heidegger, Adorno, Dewey, and others is used to investigate how the modern sciences and the development of capitalism change both humankind's relations to nature and the nature of value, and so affect the role of art in human self-understanding. The aesthetic dimensions of modern philosophy can help to uncover often neglected historical shifts in how 'subjective' and 'objective' are conceived. Seeing art as a kind of philosophy, and philosophy as a kind of art, reveals unresolved tensions between the different cultural domains of the modern world and questions some of the orientation of contemporary philosophy.

Modern philosophers generally assume that music is a problem to which philosophy ought to offer an answer. Andrew Bowie's Music, Philosophy, and Modernity suggests, in contrast, that music might offer ways of responding to some central questions in modern philosophy. Bowie looks at key philosophical approaches to music ranging from Kant, through the German Romantics and Wagner, to Wittgenstein, Heidegger and Adorno. He uses music to re-examine many ideas about language, subjectivity, metaphysics, truth and ethics, and he suggests that music can show how the predominant images of language, communication, and meaning in contemporary philosophy may be lacking in essential ways. His book will be of interest to philosophers, musicologists, and all who are interested in the relation between music and philosophy.

Modern philosophers generally assume that music is a problem to which philosophy ought to offer an answer. Andrew Bowie's Music, Philosophy, and Modernity suggests, in contrast, that music might offer ways of responding to some central questions in modern philosophy. Bowie looks at key philosophical approaches to music ranging from Kant, through the German Romantics and Wagner, to Wittgenstein, Heidegger and Adorno. He uses music to re-examine many ideas about language, subjectivity, metaphysics, truth and ethics, and he suggests that music can show how the predominant images of language, communication, and meaning in contemporary philosophy may be lacking in essential ways. His book will be of interest to philosophers, musicologists, and all who are interested in the relation between music and philosophy.

German philosophy remains the core of modern philosophy. Without Kant, Frege, Wittgenstein, and Husserl there would be no Anglo-American 'analytical' style of philosophy. Moreover, without Kant, Hegel, Marx, Nietzsche, and Heidegger, the 'Continental Philosophy' of Derrida, Foucault, Deleuze, Badiou, and Zizek, which has had major effects on humanities subjects in recent years, is incomprehensible. Knowledge of German philosophy is, then, an indispensable prerequisite of theoretically informed study in the humanities as a whole. German Philosophy: A Very Short Introduction discusses the idea that German philosophy forms one of the most revealing responses to the problems of 'modernity'. The rise of the modern natural sciences and the related decline of religion raises a series of questions, which recur throughout German philosophy, concerning the relationships between knowledge and faith, reason and emotion, and scientific, ethical, and artistic ways of seeing the world. There are also many significant philosophers who are generally neglected in most existing English-language treatments of German philosophy, which tend to concentrate on the canonical figures. This Very Short Introduction will include reference to these thinkers and suggests how they can be used to question more familiar German philosophical thought. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Certainly one of the key German philosophers of the twentieth century, Hans-Georg Gadamer also influenced the study of literature, art, music, sacred and legal texts, and medicine. Indeed, while much attention has been focused on Gadamer's writings about ancient Greek and modern German philosophy, the relevance of his work for other disciplines is only now beginning to be properly considered and understood. In an effort to address this slant, this volume brings together many prominent scholars to assess, re-evaluate, and question Hans-Georg Gadamer's works, as well as his place in intellectual history. The book includes a recent essay by Gadamer on 'the task of hermeneutics', as well as essays by distinguished contributors including Jurgen Habermas, Richard Rorty, Gerald Bruns, Georgia Warnke, and many others. The contributors situate Gadamer's views in surprising ways and show that his writings speak to a range of contemporary debates - from constitutional questions to issues of modern art. A controversial final section attempts to uncover and clarify Gadamer's history in relation to National Socialism. More an investigation and questioning than a celebration of this venerable and profoundly influential philosopher, this collection will become a catalyst for any future rethinking of philosophical hermeneutics, as well as a significant starting place for rereading and reviewing Hans-Georg Gadamer.