After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Biobanking, i.e. storage of biological samples or data emerging from such samples for diagnostic, therapeutic or research purposes, has been going on for decades. However, it is only since the mid 1990s that these activities have become the subject of considerable public attention, concern and debate. This shift in climate is due to several factors. The purpose of this book is to investigate some of the ethical, legal and social challenges raised by research biobanking in its different modern forms and formats. The issues raised by research biobanking in its modern form can be divided into four main clusters: how biological materials are entered into the bank; research biobanks as institutions; under what conditions researchers can access materials in the bank, and problems concerning ownership of biological materials and of intellectual property arising from such materials; and how the information is collected and stored, e.g. access-rights, disclosure, confidentiality, data security and data protection.

Global navigation satellite systems like GPS or the future European Galileo are influencing the world of navigation tremendously. Today, everybody is concerned with navigation even if unaware of this fact. Therefore, the interest in navigation is increasing. This book provides an encyclopedic view of navigation. Fundamental elements are presented for a better understanding of the techniques, methods, and systems used in positioning and guidance. The book is divided into three parts. Besides a historical review and maps, the first part covers mathematical and physical fundamentals. The second part treats the methods of positioning including terrestrial, celestial, satellite-based, inertial, image-based, and integrated navigation. Routing and guidance are the main topics of the third part. Applications on land, at sea, and in the air are considered. The book is designed for students, teachers, and people interested in entering the complex world of navigation.

Biobanking, i.e. storage of biological samples or data emerging from such samples for diagnostic, therapeutic or research purposes, has been going on for decades. However, it is only since the mid 1990s that these activities have become the subject of considerable public attention, concern and debate. This shift in climate is due to several factors. The purpose of this book is to investigate some of the ethical, legal and social challenges raised by research biobanking in its different modern forms and formats. The issues raised by research biobanking in its modern form can be divided into four main clusters: how biological materials are entered into the bank; research biobanks as institutions; under what conditions researchers can access materials in the bank, and problems concerning ownership of biological materials and of intellectual property arising from such materials; and how the information is collected and stored, e.g. access-rights, disclosure, confidentiality, data security and data protection.

This book defines management mistakes and offers a variety of models to classify and interpret them. It describes the evolution of management mistakes, techniques for identifying and disclosing mistakes, the relationship between management and medical mistakes, and steps to prevent and correct mistakes. Six case studies, drawn from a real set of events in healthcare organizations, describe management mistakes and are followed by commentaries by experts in the field of healthcare management. They indicate steps that might have produced more positive outcomes. Ultimately, managers will not be completely successful in making healthcare better and more cost-effective without viewing mistakes as learning opportunities. This book is written for healthcare managers throughout the world and for the benefit of their patients, staff and communities.

This new edition accommodates the most recent advances in GPS technology. Updated or new information has been included although the overall structure essentially conforms to the former editions. The textbook explains in comprehensive manner the concepts of GPS as well as the latest applications in surveying and navigation. Description of project planning, observation, and data processing is provided for novice GPS users. Special emphasis is put on the modernization of GPS covering the new signal structure and improvements in the space and the control segment. Furthermore, the augmentation of GPS by satellite-based and ground-based systems leading to future Global Navigation Satellite Systems (GNSS) is discussed.

3 Bei der Nachbildung von Gegenstiinden der sichtbaren Umgebung stimmt ja der subjektive MaBstab fUr die Vorlage und die Nachbildung miteinander iiberein. Diese wiirden also richtig wiedergegeben werden, trotzdem sie der Person im angefiihrten FaIle von Makropsie zu groB erscheinen. Solcbe Untersuchungen, die meines Wissens noch nicbt angestellt worden sind, wiirden die hier besprochenen Zusammenhiinge zwischen scheinbarer und wirklicherc GroBe sebr gut veranschaulichen. Sie wiirden namentlicb an schaulicb die Beschriinkung aufzeigen, die uns in bezug auf das Erkennen der RaumgroBen auferlegt ist. N ehmen wir an, ein anderer batte von jeher alles viel groBer geseben, als wir, so wiirden ihm auch seine Be wegungen entsprechend groBer erseheinen, er wiirde sich gewohnt haben, mit einem kleineren AusmaB von Bewegung die Vorstellung einer viel groBeren Strecke zu verkniipfen 1). Wir wiirden also die abweichende GroBen sehatzung aus seinen Bewegungen nicht erkennen, und aueh sonst konnte er es uns in keiner Weise mitteilen, daB ihm alles viel groBer erscheint, als uns. Die GroBe der Sehdinge ist also eine subjektive Reaktion unseres Sehorgans auf den auBeren Reiz, die individuell variieren kann und ob jektiv nicht meBbar ist. Nach dem Gesagten ist ein Vergleich der absoluten GroBe der Seh dinge mit einer gedacbten wirklichenc GroBe der Objekte unmoglichj wir konnen nur die GroBenverhaltnisse der Sehdinge und ihre gegenseitige Lage vergleichen mit den GroBenverhaltnissen und der gegenseitigen Lage der ihnen entsprechenden auBeren Objekte."

This book defines management mistakes and offers a variety of models to classify and interpret them. It describes the evolution of management mistakes, techniques for identifying and disclosing mistakes, the relationship between management and medical mistakes, and steps to prevent and correct mistakes. Six case studies, drawn from a real set of events in healthcare organizations, describe management mistakes and are followed by commentaries by experts in the field of healthcare management. They indicate steps that might have produced more positive outcomes. Ultimately, managers will not be completely successful in making healthcare better and more cost-effective without viewing mistakes as learning opportunities. This book is written for healthcare managers throughout the world and for the benefit of their patients, staff and communities.