The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

Hormones and Signaling focuses on the mechanism of gene regulation at the cellular level. It also covers the way hormones act to modulate gene regulation and animal development.
Key Features
* Includes information on:
* Nuclear receptors, coactivators, and corepressors
* Membrane receptors, kinases, and phosphorylation on cascades
* Hormonal regulation of development
* Calcium channels and neurotransmitters
* Chromatin, transcription factors, and regulation of gene expression
* JAK/STAT pathways
* Hormone-regulated development and gene "knock-out"

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

Operative procedures performed directly on the base of the brain, inner ear, and cranial nerves are inherently delicate undertakings further complicated by the difficulty of achieving easy access to this confined space. Written by pioneers working at one of the world's leading centers for advanced neurosurgery, An Atlas of Skull Base Surgery clearly describes the steps by which each of the key anatomical structures at the skull base and inner ear may be accessed in order to perform advanced surgical interventions.

Featuring over 170 specially commissioned diagrams, and over 100 photographs of MRI, CT, and other imaging modalities, the atlas comprehensively covers a range of surgical approaches. The authors use the detailed supporting artwork to demonstrate the main steps in each procedure and help readers conceptualize the anatomy and surgical trajectory. With extensive accompanying notes on patient assessment and postoperative care, An Atlas of Skull Base Surgery facilitates the complete evaluation and management of patients with skull base lesions in which the clinical presentation or cell type mandates an operative procedure.

Cancer surgery of the mouth and throat can involve major incision wounds, tracheotomy, or necessitate the breaking of bones. Recognizing the benefits and success of robotic surgery in other areas of medicine, the authors present its use in head and neck surgery, resulting in less surgery, less deformity, and faster rehabilitation. In this new book, the authors describe the preoperative aspects of Transoral Robotic Surgery (TORS), including patient evaluation, instrumentation and set-up, moving on to diagnostic endoscopic and surgical techniques for tonsillectomy, laryngectomy, tongue base and glottic resection, and speech and swallowing considerations. They conclude with an examination of the potential for TORS in skull-base surgery, its future application and, importantly, telesurgery via the Internet. A pioneering book for a pioneering surgical technique in head and neck surgical technique and management, this should be on the shelf of every otolaryngology-head and neck surgeon. http://www.youtube.com/watch?feature=player_embedded&v=DTp7Mv9hkbI