While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

"Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga" brings together interdisciplinary and integrative approaches to health and medicine in one comprehensive reference. It covers the concept of Evidence Based Medicine (EBM) as a common thread to connect medical systems, facilitating dialogue and triggering the evolution of Integrative Medicine. The basic principles of Ayurveda and Yoga are connected and juxtaposed to the modern systems biology including the complex relationships between cells, tissues, organs and body to get better and inclusive picture of Integrative Medicine. This book introduces readers the potentials of Ayurveda and Yoga as important components of Integrative Medicine as also knowledge sources for future research in biomedicine.
Contains a confluence of ancient and modern concepts, historical perspectives, philosophical underpinnings and an extensive review of literature supported by worldwide case studies. Provides a contemporary analysis of ancient wisdom, pointing to potential areas for future research, allowing for contemplation of forthcoming healthcare and integrative medicine practices.Offers illustrative charts, timelines and entity relationship logic diagrams for enhanced understanding of concepts presented.Shows Ayurveda knowledge and its relevance to drug discovery, personalized medicine, genomics, epigenomics, regenerative medicine, longevity, and nanotechnology.Shares yoga knowledge insights and explains its relevance to body -mind complex relationships, psycho-neuro-immuno-endocrinology, bioenergetics, consciousness, and cognitive sciences.

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.