The setting of limit values for environmental noxae is essentially based on measurements and data from single exposures. To an increasing degree, however, there are demands also to consider combined exposures. Hence, in this study, the necessity and feasability of environmental standards for combined exposures have been examined from the scientific, medical, economic, legal, sociological and philosophical/ethical perspective. Starting from effect mechanisms, criteria have been established which, in spite of the complexity of the issues, enable us to set limit values in order to achieve given environmental quality targets. This study endeavours to reveal and explain gaps in knowledge and to point to possible solutions from the scientific and medical point of view. The results should support efforts to shape a practical legal framework and viable economic procedures for environmental standards on combined exposures, taking into consideration the standards and perceptions existing in our communities.

This book offers an authoritative analysis of the state-of-the art in energy and climate research and policy. It starts by describing the current status of technologies that are expected to have an influence on the energy systems of the future. For an adequate evaluation, it presents the latest findings on the effects of energy supply and consumption as well as of the emissions on both the environment and people's health. This is followed by an extensive discussion of the economic and social problems related to climate change, the need for energy transitions, and other issues that may require public investment and international agreements. The book reviews the problem of energy policy from a global perspective, providing readers with the technical, political, economic and ethical background needed to understand the current situation and work at better solutions for a sustainable, just and prospering world.

Radioactive waste (above all highly radioactive wastes from nuclear installations) caused by research, medicine and technology must be disposed of safely. However both the strategies disputed for the disposal of radioactive waste as well as concrete proposals for choosing a location for final waste disposal are highly debatable.
An appropriate disposal must conform to both complex, technical requirements and fulfill the radio-biological conditions to appropriately protect man and nature. Ethical, legal and social conditions must also be considered. An interdisciplinary team from various, relevant fields compiled the current status-quo and developed criteria and strategies, which on the one hand meet the requirements of optimal warning and prevention of risk for present and future generations, and additionally on the other hand meet the needs of what current society agrees what is expected to be allowed.
This study can be understood as an advanced and continuing contribution to the corresponding scientific specialized debates, due to its interdisciplinary treatment. At the same time it serves as a fundamentally informing contribution to public and political debates, offering an easily comprehensible executive summary and precise content recommendations.

Tumour therapy depends essentially on being able to destroy the clonogenic activity of tumour cells while keeping the damage to the normal tissue low. Clinical experience shows that tumour response varies greatly even if tumours with the same localisation, clinical, and histopathological staging are compared. Some tumours appear to be resistant to conventional radiotherapy (X-rays, y-rays or fast electrons) or chemotherapy. In these cases new therapy modalities are necessary. Combined therapy modalities seem to have advan- tages for some resistant tumours; one possibility of such a treatment is to combine radiotherapy or chemotherapy with hyperthermia. This means that the local tumour, the tumour region or even the whole body of the patient has to be heated to temperatures between 40 to 45 C (in case of whole body hyperthermia to 42 C maximal) for a certain time (usually 30-60 min are adequate). Hyperthermia has a long tradition in medicine as a treatment modality for various diseases. Inscriptions of the old Egyptians and texts of the Greeks have pointed out its importance. Usually whole body hyperthermia has been used by the induction of fever. Local hyperthermia began around 1900 when Westermark treated unre- sectable cervix carcinomas with hot water in a metallic coil. By the beginning of this century an increase of radiation effects was hy- pothesised with hypothermia and later observed. However, only in the 1960s and 1970s were systematic investigations started which showed radiosensitisation and chemosensitisation by hyperthermia in cells and tissues including tumours.

The rapid growth of the world population - nearly six-fold over the last hundred years - combined with the rising number of technical installations especially in the industrialized countries has lead to ever tighter and more strained living spaces on our planet. Because ofthe inevitable processes oflife, man was at first an exploiter rather than a careful preserver of the environment. Environmental awareness with the intention to conserve the environment has grown only in the last few decades. Environmental standards have been defined and limit values have been set largely guided, however, by scientific and medical data on single exposures, while public opinion, on the other hand, now increasingly calls for astronger consideration of the more complex situations following combined exposures. Furthermore, it turned out that environmental standards, while necessarily based on scientific data, must also take into account ethical, legal, economic, and sociological aspects. A task of such complexity can only be dealt with appropriately in the framework of an inter disciplinary group."

This book offers an authoritative analysis of the state-of-the art in energy and climate research and policy. It starts by describing the current status of technologies that are expected to have an influence on the energy systems of the future. For an adequate evaluation, it presents the latest findings on the effects of energy supply and consumption as well as of the emissions on both the environment and people's health. This is followed by an extensive discussion of the economic and social problems related to climate change, the need for energy transitions, and other issues that may require public investment and international agreements. The book reviews the problem of energy policy from a global perspective, providing readers with the technical, political, economic and ethical background needed to understand the current situation and work at better solutions for a sustainable, just and prospering world.

With a global growth in the demand for energy, secure and economical energy supplies play a key role in human development. Based on present-day energy supply technology, our knowledge of available resources and the development of new forms of energy, the study develops an assessment of future energy supplies. It takes account of both the economic and - above all - the ethical dimensions involved. Key Features topical issue with potentially explosive political and economic consequences comprehensive multi-facetted and multidisciplinary approaches to solutions