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Hyperthermia and the Therapy of Malignant Tumors (Paperback, Softcover reprint of the original 1st ed. 1987)
Loot Price: R2,776
Discovery Miles 27 760
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Hyperthermia and the Therapy of Malignant Tumors (Paperback, Softcover reprint of the original 1st ed. 1987)
Series: Recent Results in Cancer Research, 104
Expected to ship within 10 - 15 working days
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Total price: R2,796
Discovery Miles: 27 960
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Tumour therapy depends essentially on being able to destroy the
clonogenic activity of tumour cells while keeping the damage to the
normal tissue low. Clinical experience shows that tumour response
varies greatly even if tumours with the same localisation,
clinical, and histopathological staging are compared. Some tumours
appear to be resistant to conventional radiotherapy (X-rays, y-rays
or fast electrons) or chemotherapy. In these cases new therapy
modalities are necessary. Combined therapy modalities seem to have
advan- tages for some resistant tumours; one possibility of such a
treatment is to combine radiotherapy or chemotherapy with
hyperthermia. This means that the local tumour, the tumour region
or even the whole body of the patient has to be heated to
temperatures between 40 to 45 C (in case of whole body hyperthermia
to 42 C maximal) for a certain time (usually 30-60 min are
adequate). Hyperthermia has a long tradition in medicine as a
treatment modality for various diseases. Inscriptions of the old
Egyptians and texts of the Greeks have pointed out its importance.
Usually whole body hyperthermia has been used by the induction of
fever. Local hyperthermia began around 1900 when Westermark treated
unre- sectable cervix carcinomas with hot water in a metallic coil.
By the beginning of this century an increase of radiation effects
was hy- pothesised with hypothermia and later observed. However,
only in the 1960s and 1970s were systematic investigations started
which showed radiosensitisation and chemosensitisation by
hyperthermia in cells and tissues including tumours.
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