Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Radiotherapy
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Targeted Radionuclide Tumor Therapy - Biological Aspects (Hardcover, 2008 ed.)
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Targeted Radionuclide Tumor Therapy - Biological Aspects (Hardcover, 2008 ed.)
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The last three decades have provided opportunities to explore the
potential of treating malignant diseases with antibodies or other
targeting molecules labelled with nuclides. While considerable
advances have been reported, there is still a signi- cant amount of
work left to accomplish before our ambitions can be achieved. It
now seems timely to review the accomplishments achieved to date and
to clarify the challenges that remain. The choice of radionuclide,
the conjugation p- cedure employed, and the selection of suitable
targets were early issues that were faced by our field that still
persist, however we can now tackle these obstacles with
significantly better insight. The expanding array of new targeting
molecules (recombinant antibodies, peptides and agents based upon
alternate scaffolds) may increase the therapeutic efficacy or even
modify the radiation sensitivity of the targeted tumor cell. The
title of this book "Targeted Radionuclide Tumour Therapy -
Biological Aspects" was selected to reinforce the concept that a
major focus of this volume was devoted to understanding the
biological effects of targeting and radiation. These important
issues have not previously been the primary focus in this context.
Furthermore, our rapidly expanding knowledge of different types of
cell death and the increasingly likely existence of cancer stem
cells suggests to us that even more efficient approaches in
targeting might be possible in the future.
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