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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Radiotherapy
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Increasing the Therapeutic Ratio of Radiotherapy (Hardcover, 1st ed. 2017)
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Increasing the Therapeutic Ratio of Radiotherapy (Hardcover, 1st ed. 2017)
Series: Cancer Drug Discovery and Development
Expected to ship within 12 - 17 working days
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Total price: R4,964
Discovery Miles: 49 640
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Current cancer therapies are focused on three general strategies:
modifying intrinsic radiosensitivity via molecular targeting,
manipulating microenvironmental factors to enhance tumor
susceptibility to radiation, and improving delivery of radiation to
critical tumor locations while sparing normal tissues. The goal of
this volume is to describe a number of promising approaches
corresponding to each strategy. In general, research in radiation
oncology tends to be siloed into fundamental biology, physics or
treatment delivery. The strategies for improving therapeutic ratio
encompassed in this book will involve each of these components of
radiation oncology. Thus, they will illustrate the variety of
disparate approaches available for potentially improving the
efficacy of radiotherapy, which may then stimulate discussion
across disciplines and foster further translational investigations.
Although a goal of each chapter will be to highlight advances
within an approach, of equal importance will be the delineation of
barriers to successful clinical application and how to overcome or
minimize such impediments. Along these lines, because therapeutic
ratio incorporates both tumor and normal tissue radio response, a
point of emphasis will be the mechanistic rationale for selectively
modifying tumor (sensitization) or normal cells (protection).
Finally, whereas the literature is replete with studies describing
potential targets/strategies for increasing the therapeutic ratio
for radiotherapy, this book will focus on those supported by in
vivo data consistent with impending translational application along
with those that are already being evaluated in the clinic.
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