This book constitutes the proceedings of the 4th Iberoamerican Conference and third Indo-American Conference on Knowledge Graphs and Semantic Web, KGSWC 2022, which took place in Madrid, Spain, in November 2022. The 22 full and 3 short research papers presented in this volume were carefully reviewed and selected from 63 submissions. The papers cover topics related to software and its engineering, software creation and management, Emerging technologies, Analysis and design of emerging devices and systems, Emerging tools and methodologies and others.