Concern has grown in Congress and elsewhere about China's military modernisation. The topic is an increasing factor in discussions over future required U.S. Navy capabilities. The issue for Congress addressed in this book is: How should China's military modernisation be factored into decisions about U.S. Navy programs? Several laments of China's military modernisation have potential implications for future required U.S. Navy capabilities. These include theatre-range ballistic missiles (TBMs), land-attack cruise missiles (LACMs), anti-ship cruise missiles (ASCMs), surface-to-air missiles (SAMs), land-based aircraft, submarines, surface combatants, amphibious ships, naval mines, nuclear weapons, and possibly high-power microwave HPM) devices. China's naval limitations or weaknesses include capabilities for operating in waters more distant from China, joint operations, C4ISR (command, control, communications, computers, intelligence, surveillance, and reconnaissance), long-range surveillance and targeting systems, anti-air warfare (AAW), antisubmarine warfare (ASW), mine countermeasures (MCM), and logistics. Observers believe a near-term focus of China's military modernisation is to field a force that can succeed in a short-duration conflict with Taiwan and act as an anti-access force to deter U.S. intervention or delay the arrival of U.S. forces, particularly naval and air forces, in such a conflict. Some analysts speculate that China may attain (or believe that it has attained) a capable maritime anti-access force, or elements of it, by about 2010. Other observers believe this will happen later. Potential broader or longer-term goals of China's naval modernisation include asserting China's regional military leadership and protecting China's maritime territorial, economic, and energy interests. China's naval modernisation has potential implications for required U.S. Navy capabilities in terms of preparing for a conflict in the Taiwan Strait area, maintaining U.S. Navy presence and military influence in the Western Pacific, and countering Chinese ballistic missile submarines. Preparing for a conflict in the Taiwan Strait area could place a premium on the following: on-station or early-arriving Navy forces, capabilities for defeating China's maritime anti-access forces, and capabilities for operating in an environment that could be characterised by information warfare and possibly electromagnetic pulse (EMP) and the use of nuclear weapons. Certain options are available for improving U.S. Navy capabilities by 2010; additional options, particularly in shipbuilding, can improve U.S. Navy capabilities in subsequent years. China's naval modernisation raises potential issues for Congress concerning the role of China in Department of Defense (DOD) and Navy planning; the size of the Navy; the Pacific Fleet's share of the Navy; forward homeporting of Navy ships in the Western Pacific; the number of aircraft carriers, submarines, and ASW-capable platforms; Navy missile defence, air-warfare, AAW, ASW, and mine warfare programs; Navy computer network security; and EMP hardening of Navy systems.

Alcoholism is a complicated disorder that is often characterised with refractoriness to treatment, chronic course, high comorbidity and frequently with aggressive and suicidal behaviour. The neurobiological basis of alcoholism is assumed to be associated with the altered functions of different neurotransmitter (opioid, GABA, dopamine or serotonin (5-hydroxytryptamine, 5-HT)) systems. The association between central serotonergic function and the development and maintenance of alcohol abuse and dependence is based on the preclinical and clinical data, which show decreased 5-HT function associated with alcohol abuse. Peripheral biochemical markers might be used to improve the understanding of the underlying neurobiology of alcoholism, but also for the screening, establishing the diagnosis, disease staging, prediction of the suicidal risk and prediction and monitoring of treatment. Since 5-HT synaptosomes in the central nervous system and platelets similarly store, release and metabolise 5-HT, blood platelets have been widely used as a limited peripheral model for the central serotonergic synaptosomes. Various 5-HT abnormalities are frequently found in alcoholism, and decreased plasma tryptophan levels, decreased but also unaltered concentration of platelet 5-HT, increased platelet 5-HT uptake, and decreased and unchanged platelet monoamine oxidase (MAO) activity in alcoholic subjects have been reported. Deficits in central 5-HT function in alcoholic subjects were also detected after a challenge tests with fenfluramine, m-clorophenylpiperasine, and 6-chloro-2-1-piperazinylpyrazine, which resulted in blunted prolactin and cortisol responses. Alcoholism is frequently associated with different comorbid psychiatric disorders (personality disorder, PTSD, anxious-depressive disorder, major depression, schizophrenia), and with nicotine addiction. Clinical diagnosis of alcoholism was made according to the DSM-IV criteria, using Structured clinical interview and CAGE. Different clinical symptoms were evaluated using Hamilton Rating Scale for Depression and Anxiety. Control group consisted of drug free healthy persons with no personal or family history of alcoholism, who did not consume any alcohol beverage 24 h prior to sampling. All subjects fulfilled the questionnaire regarding their smoking habits. Biomarkers studied were platelet 5-HT concentration, platelet MAO activity, and routine laboratory tests, determined using spectrofluorimetric and photometric methods. Since platelet 5-HT concentration and/or MAO activity are under influence of sex, psychotic or depressive symptoms, suicidal behaviour, smoking status, or different psychiatric comorbid diagnoses, the authors determined platelet 5-HT concentration and platelet MAO activity in the large groups of drug-free alcoholics who were admitted into hospital due to the withdrawal syndrome related to alcohol dependency, and compared these values in the sex-matched healthy controls. They also investigated whether sex, smoking status, the presence of psychotic or depressive symptoms, suicidal behavior, number of cigarettes smoked per day, or different psychiatric comorbid diagnoses, would affect platelet 5-HT and MAO in male and female alcoholic patients. The data suggest that biological markers are very important research tool in alcoholism, since they can be used to determine the baseline characteristics of the alcoholic groups, to predict a suicidal risk in alcoholism, to predict efficacy in alcoholism treatment trials, to predict therapeutic response to medications in alcoholism, to measure alcohol consumption, and to be used in forensic toxicology.