This volume contains the proceedings of the Summer Program on Nonlinear Conservation Laws and Applications held at the IMA on July 13--31, 2009. Hyperbolic conservation laws is a classical subject, which has experienced vigorous growth in recent years. The present collection provides a timely survey of the state of the art in this exciting field, and a comprehensive outlook on open problems. Contributions of more theoretical nature cover the following topics: global existence and uniqueness theory of one-dimensional systems, multidimensional conservation laws in several space variables and approximations of their solutions, mathematical analysis of fluid motion, stability and dynamics of viscous shock waves, singular limits for viscous systems, basic principles in the modeling of turbulent mixing, transonic flows past an obstacle and a fluid dynamic approach for isometric embedding in geometry, models of nonlinear elasticity, the Monge problem, and transport equations with rough coefficients. In addition, there are a number of papers devoted to applications. These include: models of blood flow, self-gravitating compressible fluids, granular flow, charge transport in fluids, and the modeling and control of traffic flow on networks.

Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.

The Workshop on Hyperbolic Conservation Laws and Related Analysis with Applications at the International Centre for Mathematical Sciences (Edinburgh, UK) held in Edinburgh, September 2011, produced this fine collection of original research and survey articles. Many leading mathematicians attended the event and submitted their contributions for this volume.This book presents thirteen papers, representing the most significant advances and current trends in nonlinear hyperbolic conservation laws, related analysisand applications. Topics covered include a survey on multidimensional systems of conservation laws as well as novel results on liquid crystals, conservation laws with discontinuous flux functions, and applications to sedimentation. Also included are articles on recent advances in the Euler equations and the Navier Stokes Fourier Poisson system, in addition to new results on collective phenomena described by the Cucker Smale model.

The present volume is addressed toresearchers and graduate students interested in partial differential equations and related analysis with applications.

This book by influential policymaker Chi Fulin lays out in issue-oriented and detailed chapters, at a time when China is at a crossroads, exactly how the government plans to deal with the social, political and economic issues the world's second-largest economy faces. From managing the decline of industry, to urbanization, to managing consumption, to social security and education, Chi offers a roadmap for the years ahead. This book will be particularly fascinating to Western scholars of China who speculate on the inner workings of the Chinese policymaking elite, with the ambition of China's central planners here laid out for the world to see.

Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.

This volume contains the proceedings of the Summer Program on Nonlinear Conservation Laws and Applications held at the IMA on July 13--31, 2009. Hyperbolic conservation laws is a classical subject, which has experienced vigorous growth in recent years. The present collection provides a timely survey of the state of the art in this exciting field, and a comprehensive outlook on open problems. Contributions of more theoretical nature cover the following topics: global existence and uniqueness theory of one-dimensional systems, multidimensional conservation laws in several space variables and approximations of their solutions, mathematical analysis of fluid motion, stability and dynamics of viscous shock waves, singular limits for viscous systems, basic principles in the modeling of turbulent mixing, transonic flows past an obstacle and a fluid dynamic approach for isometric embedding in geometry, models of nonlinear elasticity, the Monge problem, and transport equations with rough coefficients. In addition, there are a number of papers devoted to applications. These include: models of blood flow, self-gravitating compressible fluids, granular flow, charge transport in fluids, and the modeling and control of traffic flow on networks.

Meet the overnight tech success stories of China's globalizing business landscape In the last few years, we have seen a meteoric rise of Chinese tech companies across the world. Alibaba stock price movements unnerved investors globally, venture capitalists searched for the next Meituan or Pinduoduo in Southeast Asia and Latin America, and of course, Tik Tok, the most popular content platform in the world today, originated from China. The founders of such companies are typically credited with the "tenacity to rough it out," the "courage to venture into the unknown," and the "vision to take their companies to new heights." However, the same can be said about Silicon Valley founders, or any successful entrepreneur. So, what gives Chinese founders and their companies the advantage in becoming multi-billion global enterprises? How does their leadership set strategies? How do they motivate their people? How do they move so fast and defend their turf in China's hyper-competitive tech market? When they expand overseas, how do they determine what they keep and what they need to let go of? And most importantly, what do these things mean to you as a competitor, investor, regulator, or even as an executive or customer of such companies? Seeing the Unseen: Behind Chinese Tech Giants' Global Venturing answers these questions and delves into the fascinating world of Chinese logic that shapes how tech leaders make and implement decisions, many of which are seldom seen outside China. In this book, you will gain an accurate, concise understanding of Chinese tech companies' reflections as they scale. You will understand the different generations of Chinese tech giants from Alibaba, Tencent, Baidu and Huawei to Pinduoduo, Meituan, ByteDance, Xiaomi and more. In this Seeing the Unseen, the analysis behind the success and lessons learned is summarized into a unique framework that touches on People, Organization, and Product and Leadership (POP-Leadership). The book covers: How Chinese history, folklore and Mao Zadong's political strategies have shaped the strategies of Chinese tech leaders, even today The mindsets of Chinese tech and internet companies and how they have evolved over the last two decades The unique business culture and leadership styles that steered these companies through uncertain and ultra-competitive periods How Chinese companies structure their organizations and products and how they remain agile as they scale The limitations of Chinese POP-Leadership, and what these companies must shed to keep up with international players in global markets How Chinese POP-Leadership is now becoming international, and how international players are leveraging these learnings How the worldwide expansion of Chinese companies will alter the business landscape in the coming decades Chinese firms undertaking overseas ventures can challenge our thinking on global strategy and implementation. This book gives you a better understanding of these emergent players in the global arena.

This book by influential policymaker Chi Fulin lays out in issue-oriented and detailed chapters, at a time when China is at a crossroads, exactly how the government plans to deal with the social, political and economic issues the world's second-largest economy faces. From managing the decline of industry, to urbanization, to managing consumption, to social security and education, Chi offers a roadmap for the years ahead. This book will be particularly fascinating to Western scholars of China who speculate on the inner workings of the Chinese policymaking elite, with the ambition of China's central planners here laid out for the world to see.

This book is an all-in-one resource on the development and application of variable frequency transformers to power systems and smart grids. It introduces the main technical issues of variable frequency transformers (VFT) systematically, including its basic construction, theory equations, and simulation models. Readers will then gain an in-depth discussion of its control system, operation performance, low frequency power oscillation, and technical economics, before proceeding to practical implementation and future developments. The related concepts of energy revolution, third generation grids, and power system interconnection are discussed as well. The first, comprehensive introduction to variable frequency transformers (VFT) An in-depth look at the construction of VFT, with simulations and applications Demonstrates how to assess the control system and overall system performance Analyses future developments, energy revolution and power system interconnections Variable Frequency Transformers for Large Scale Power Systems is a timely overview of the state of the art for VFT as it is increasingly adopted in smart grids. It is intended for engineers and researchers specializing in power system planning and operation, as well as advanced students and industry professionals of power engineering.

Female sex hormones are produced in both females and males. They influence almost every aspect of human physiological functions, activities and behaviours. Disturbance in female sex hormones may result in variety of disorders including cancer. Attention is usually focused on female sex hormone-related cancers in reproductive organs in females such as breast, cervix and ovary. However, advances in science have discovered that female sex hormones also have a great impact on cancers in non-reproductive organs and tissues such as colon, oesophagus and thyroid in both men and women. This book describes and summarises the up-to-date information on an emerging topic of female sex hormones and cancer.

This 8-chapter book is written by experts from China, Mexico, Portugal, United Kingdom and the United States of America. The book is focused on estrogen receptor structure, functions and clinical significance. Though we are unable to address all aspects of the estrogen receptors, we have analysed and discussed estrogen receptors or their isoforms in some major estrogen receptor-related disorders including cancers, endocrine diseases, respiratory diseases and obesity. The information provided by this book should aid our understanding the role of estrogen receptors in human diseases. This book will be of great value not only for clinicians interested in estrogen receptor-related diseases but also for basic scientists working in the field of estrogen receptors.

The thoroughly updated and expanded Second Edition of Greg G. Chen, Lynne A. Weikart, and Daniel W. Williams' Budget Tools: Financial Methods in the Public Sector brings together scores of exercises that will take students through the process of public budgeting, from organizing data through analysis and presentation. This thoroughly revised text has been restructured - it now has 30 compact modules to focus on individual skills and enhance flexibility, and is reorganized to cover more straightforward skills early in the book and more complex tools later on. Using budgets from all levels of government as well as from nonprofit organizations, the authors give students the opportunity to work with real budgeting data to cover a range of topics and skills. Budget Tools provides instruction in the techniques and implementation of budgeting skills at a granular level to support a wide range of approaches to teaching the subject.