This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

The present book provides a state-of-the-art overview of the adrenal gland pathophysiology. It covers both up-to-date basic and clinical notions on adrenal glands. Amidst the molecular aspects, discussed by leading scientists in the field, there are ER stress, microRNA, hormone biosynthesis, and interactions with other organs. Clinical insights for students and physicians are also provided, from the imaging to the therapeutic management of common disorders of the gland, including adrenal failure, hyperaldosteronism, Cushing's syndrome, neurologic disease, and cancer both in adults and pediatric patients. As mentioned above, chapter contributions are made by worldwide renowned experts, scientists and physicians, working in prestigious hospitals and universities including Brown, Oxford, Case Western Reserve University, Cleveland Clinic, Chinese University of Honk Kong, University of Tennessee, Indiana University School of Medicine, Monash Health in Clayton, Australia, University of Calgary, Northern Ontario School of Medicine and Laurentian University, Medical University of Gdansk, Universite Pierre et Marie Curie in Paris, France, University of Minho, Braga, Portugal, St. Vincent's University Hospital in Dublin, Universities of Londrina, Alfenas, Sao Paulo, and Rio de Janeiro, Brazil. Throughout these chapters, the authors spotlight future avenues for research in basic pathophysiology and in therapy/prevention, in addition to thorough overviews of the current literature pertaining to the adrenal gland and its functional roles. The book also includes several color photographs, schemes and diagrams of molecular relationships, and tables that support and complement the text. The comprehensive and systematic overview provided within this book is expected to assist the reader in comprehending the importance of taking into account the functional roles of the adrenal gland and also to address questions and unresolved issues regarding the treatment of its disorders. Finally, the editor would like to express his sincere appreciation to all the contributors for their dedicated collaboration in this project. He would also like to thank Ms. Carra Feagaiga for her patient support. He sincerely hopes this book will enable readers to connect basic research principles with up-to-date clinical knowledge, thereby encouraging future discoveries and developments of new therapeutic strategies to treat disorders of the adrenal gland.

This book provides an overview of the scientific methods used to search, analyse, appraise and synthesise studies on angiogenesis. It is intended to serve as a comprehensive piece of literature that encompasses all aspects from the molecular features of angiogenesis to the clinical value and potential pitfalls of angiogenic-based therapies. The primary motion to write this book is to provide an overview of the current status of the research in this field, with a focus on both tumoural and non-tumoural disease. Effects of various anti-angiogenic and pro-angiogenic molecules are also addressed in detail. This book comes at an important time in the development of so-called "translational medicine". Its purpose is to explain all the molecular bases underlying the angiogenic process and apply them to the clinical world. Reviewed and addressed are the basic concepts and importance of new drugs in clinical trials to inhibit or promote angiogenesis. This book may be considered as a scholarly reference work for libraries and researchers across the world and as a supplementary text for courses in medicine, physiology, biochemistry, molecular and cellular biology. It is expected that readers, both basic researchers and clinicians, will gain a good understanding of the essential value of angiogenesis in health and disease.