Advances in Cancer Researchprovides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics
Provides invaluable information on the exciting and fast-moving field of cancer research.
Outstanding and original reviews are presented on a variety of topics.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics

This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis and colleagues, discusses the effect of MAP kinase cascades as examples of signal transduction mechanisms in signaling pathways. In Chapter 4, Sozi "et al." Review the frequent abnormalities found in the "FHIT" gene in a variety of cancer-derived cell lines. Volume 74 concludes with an overview by J.J. Hsuan and co-workers of the cellular functions of PtdlnsP2 and the regulation of its biosynthesis.

Academic Press proudly presents this Cumulative Subject Index covering Volumes 50-72 of Advances in Cancer Research. In one comprehensive source, the interested reader can find references to specific articles on topics such as breast cancer, prostate cancer, Kaposi's sarcoma, Burkitt's lymphoma, leukemias, oncogenes, transcription factors, tumor genetics, p53, T-cell receptors, and drug resistance. This cumulative index will serve not only as a complete overview of the major topics published in Advances in Cancer Research, but also as an indicator of the progress made in cancer research over the last ten years.

Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok "et all." Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

Volume 70 begins with two "Foundations in Cancer Research" articles, a staple of the Advances in Cancer Research series. The first article by Michael Stoker presents a review of some of the early advances made by cancer cell biology researchers. The second article by Emmanuel Farber describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes to prevent or delay carcinomas. Chidambaram and Dean illustrate the tumors and associated malformations of nevoid basal cell carcinoma. Koli and Keski-Oja review the effects of how transforming growth factor-b regulates cell proliferation, differentiation, and morphogenesis and its regulation by the steroid hormone superfamily. Jean-Marc Lemaitre and colleagues discuss the involvement of protooncogenes in the control of the cell cycle and embryonic development with specific attention paid to c-Myc expression and c-Myc function. A review of the various studies involving tumor-infiltrating lymphocytes and their possible role in cancer prevention is presented by Steven Rosenberg and co-workers. Finally, Bruce Ponder and Darrin Smith review the genetic and biological aspects of multiple endocrine neoplasia type-2 syndromes and the phenotypes associated with "ret" mutations.

This volume of Advances in Cancer Research begins with a "Foundations in Cancer Research" articles by Harold Varmus. He focuses on Andrew Lwoff who influenced a generation of scientists and how Dr. Lwoff's influence on Howard Temlin, in particular, led to the identification of the cause of AIDS. Hiroto Okayama and colleagues discuss the conserved control mechanisms of the G1 and G2 phases in fission yeasts and mammals, and the newly identified control genes. Nilis Mandahl presents the cytogenetic findings in bone and soft tissue tumors and introduces the major molecular genetic findings. Hannel Tapiovaara dn co-workers review plasmin generation at restricted areas of the cell surface and hypothesize that it may be a catalyst for tumor cells to metastasize. Noel Bouck et al. review the evidence suggesting that certain types of stimulations of inducers by activated oncogenes, and decreased production of inhibitors of angiogenesis, may be instrumental in enabling developing tumour cells to attract new cells and continue the malignant growth. Peter L. Stern reviews the role of immunity and the prospects for immune intervention in cervical neoplasia. Lastly, Denis J. Moss and his associates discuss the Epstein-Barr virus (EBV) host-virus relationship and the immune control of EBV infections and examine development of vaccines and immunotherapy.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

This book provides an ethnography of street-level policing in the United States and offers an analysis with valuable lessons for today's law enforcement officers. Author George C. Klein, sociologist and former police officer, explores the characteristics of policing in a suburb outside of large Midwestern city in the United States. As a participant-observation fieldworker, he functioned as an ethnographic researcher, recording with a sociological eye the "real world" tasks of policing, including the ordinary as well as the more remarkable aspects of day-to-day law enforcement. He approaches the data with three levels of analysis, looking at embedded issues in policing, such as discretion, danger, corruption, cynicism, race, and class; a mid-range analysis that examines police work as an example of street-level bureaucracy; and a global analysis assessing the entrenched roles of race, class, and demography in police work, as well as, society, in the U.S. This book focuses on the need for police officers to solve social problems that other institutions in society are unwilling, or unable, to solve. It examines a myriad of issues, such as police socialization, the use of force by police officers, stress levels and suicide risk factors, disparate styles of policing, police militarization, de-escalation, and more. With compelling detail, the author helps the reader understand the turmoil regarding policing in the United States today. It is ideal for police professionals as well as students and scholars of criminal justice, criminology, sociology, psychology, history, political science and journalism.

This book provides an ethnography of street-level policing in the United States and offers an analysis with valuable lessons for today's law enforcement officers. Author George C. Klein, sociologist and former police officer, explores the characteristics of policing in a suburb outside of large Midwestern city in the United States. As a participant-observation fieldworker, he functioned as an ethnographic researcher, recording with a sociological eye the "real world" tasks of policing, including the ordinary as well as the more remarkable aspects of day-to-day law enforcement. He approaches the data with three levels of analysis, looking at embedded issues in policing, such as discretion, danger, corruption, cynicism, race, and class; a mid-range analysis that examines police work as an example of street-level bureaucracy; and a global analysis assessing the entrenched roles of race, class, and demography in police work, as well as, society, in the U.S. This book focuses on the need for police officers to solve social problems that other institutions in society are unwilling, or unable, to solve. It examines a myriad of issues, such as police socialization, the use of force by police officers, stress levels and suicide risk factors, disparate styles of policing, police militarization, de-escalation, and more. With compelling detail, the author helps the reader understand the turmoil regarding policing in the United States today. It is ideal for police professionals as well as students and scholars of criminal justice, criminology, sociology, psychology, history, political science and journalism.

Covering the story of prejudice against Jews from the time of Christ through the rise of Nazi Germany, "The History of Anti-Semitism" presents in elegant and thoughtful language a balanced, careful assessment of this egregious human failing that is nearly ubiquitous in the history of Europe.
"Suicidal Europe, 1870-1933" traces the development of a belief among Europe's educated classes in an eventual Jewish domination of the West. Revealing the embedded myths about Jewish bankers and Jewish Bolsheviks in European rhetoric and histories, Poliakov demonstrates that the steady rise in anti-Semitism and suspicion of Jews in the late nineteenth century--highlighted by the Dreyfus affair--and its eventual eruption in the rise of the Nazi party in Germany in the 1920s are part of the same thread of fear and hatred that reaches back to the beginning of the first millennium.

A unique historical and literary document of lives dislocated by the collapse of East Germany. What happens when the world in which people have crafted identities for themselves and lived their lives suddenly disappears? How does a person -- or a nation -- confront such a shock? From 1990 to 1993, at an unparalleled momentin German history, Olaf Georg Klein interviewed almost a hundred fellow former East German citizens, probing their experiences of the sudden collapse of the German Democratic Republic, then crafting that material into twelve first-person narratives. The result is a literary account whose narrators include representatives from the cities and the countryside, from young and old, from the East German power elite and the resistance, as well as from those in position to be critical of both the GDR and united Germany. The book was a sensation in Germany upon its publication in 1994, and the translation will be of interest to students and scholars in history and political science, sociology, psychology, and literary studies. It includes an introduction and extensive annotations to assist the reader in understanding the East German and unified German contexts. Olaf Georg Klein's novel Aftermath was published in translation by Northwestern University Press in 1999. Ann McGlashan is Associate Professor of German and Dwight D. Allman is Associate Professor of Political Science, both at Baylor University.

The acclaimed primer of electrophysiology - from two leading experts Cardiac Arrhythmias: Interpretation, Diagnosis and Treatment, Second Edition is a practical clinical guide for healthcare professionals who seek a basic knowledge of electrophysiology and how to interpret and treat patients with arrhythmias. One of the main benefits of this book is the author's ability to take electrophysiology and break it down clearly and simply so internists and family practitioners who do not have an extensive background in this complex aspect of cardiology can understand it and its relationship to treating arrhythmias. The Second Edition has been updated to include the latest treatment advances, new and important clinical trials, additional cases, and coverage of new drugs and devices; and is enhanced by full-color tracings, and an increased number of tables and illustrations.

This new commentary on Zechariah is a part of the 46-volume New American Commentary series--an acclaimed resource for ministers and Bible students who want to understand and delve more deeply into the Scriptures. Based on the New International Version, the volume exhibits sound methodology reflecting research done in the Scripture's original languages. NIV text printed in the body of the commentary aids in cross-reference and study. Featured at academic conferences, the book is also a publicity focus on top theological blogs and publications. The author is an associate dean for the Research Doctoral Program and an associate professor Southwestern Baptist Theological Seminary in Texas. He also serves on the Old Testament editorial board for the Bulletin for Biblical Research.