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This book introduces readers to the latest advances in G
protein-coupled receptor (GPCR) biology. It reviews our current
understanding of the structural basis of ligand binding and
allosteric mechanisms, following a decade of technological
breakthroughs. Several examples of structure-based drug discovery
are presented, together with the future challenges involved in
designing better drugs that target GPCRs. In turn, the book
illustrates the important concept of GPCR biased signaling in
physiological contexts, and presents fluorescent- and light-based
methodologies frequently used to measure GPCR signaling or to trace
their dynamics in cells upon ligand activation. Taken together, the
chapters provide an essential overview and toolkit for new
scientific investigators who plan to develop GPCR projects. All
chapters were written by experts in their respective fields, and
share valuable insights and powerful methodologies for the GPCR
field.
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