Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach, Second Edition, is a primary text for a course in two-dimensional (2-D) nuclear magnetic resonance (NMR) techniques, with the goal to learn to identify organic molecular structure. It presents strategies for assigning resonances to known structures and for deducing structures of unknown organic molecules based on their NMR spectra. The book begins with a discussion of the NMR technique, while subsequent chapters cover instrumental considerations; data collection, processing, and plotting; chemical shifts; symmetry and topicity; through-bond effects; and through-space effects. The book also covers molecular dynamics; strategies for assigning resonances to atoms within a molecule; strategies for elucidating unknown molecular structures; simple and complex assignment problems; and simple and complex unknown problems. Each chapter includes problems that will enable readers to test their understanding of the material discussed. The book contains 30 known and 30 unknown structure determination problems. It also features a supporting website from which instructors can download the structures of the unknowns in selected chapters, digital versions of all figures, and raw data sets for processing. This book will stand as a single source to which instructors and students can go to obtain a comprehensive compendium of NMR problems of varying difficulty.

In April 1861, Dick and Tally Simpson, sons of South Carolina Congressman Richard F. Simpson, enlisted in Company A of the Third South Carolina Volunteers of the Confederate army. Their letters home--published here for the first time--read like a historical novel, complete with plot, romance, character, suspense, and tragedy. In their last year of college when the war broke out, Dick and Tally were hastily handed their diplomas so they could volunteer for military duty. Dick was twenty; Tally was twenty-two.
Well educated, intelligent, and thoughtful young men, Dick and Tally cared deeply for their country, their family, and their comrades-in-arms and wrote frequently to their loved ones in Pendleton, South Carolina, offering firsthand accounts of dramatic events from the battle of First Manassas in July 1861 to the battle of Chickamauga in September 1863. Their letters provide a picture of war as it was actually experienced at the time, not as it was remembered some twenty or thirty years later. It is a picture that neither glorifies war nor condemns it, but simply "tells it like it is." Written to a number of different people, the boys' letters home dealt with a number of different subjects. Letters to "Pa" went into great detail about military matters in Lee's Army of Northern Virginia--troop movements, casualties, and how well particular units had fought; letters to "Ma" and sisters Anna and Mary were about camp life and family friends in the army and usually included requests for much-needed food and clothing; letters to Aunt Caroline and her daughter Carrie usually concerned affairs of the heart, for Aunt Caroline continued to be Dick and Tally's trusted confidante, even when they were "far, far from home."
The value of these letters lies not so much in the detailed information they provide as in the overall picture they convey--a picture of how one Southern family, for better or for worse, at home and at the front--coped with the experience of war. These are not wartime reminiscences, but wartime letters, written from the camp, the battlefield, the hospital bed, the picket line--wherever the boys happened to be when they found time to write home. It is a poignant picture of war as it was actually experienced in the South as the Civil War unfolded.

GENSTAT is a general purpose statistical computing system with a flexible command language operating on a variety of data structures. It may be used on a number of computer ranges, either interactively for exploratory data analysis, or in batch mode for standard data analysis. The great flexibility of GENSTAT is demonstrated in this handbook by analysing the wide range of examples discussed in Applied Statistics - Principles and Examples (Cox and Snell, 1981). GENSTAT programs are listed for each of the examples. Most of the data sets are small but often it is these seemingly small problems which involve the most tricky statistical and computational procedures. This handbook is self-contained although for a full description of the analysis and interpretation it should be used in parallel with Applied Statistics - Principles and Examples.

This volume covers the current status of research in the neurobiology of motivated behaviors in humans and other animals in healthy condition. This includes consideration of the psychological processes that drive motivated behavior and the anatomical, electrophysiological and neurochemical mechanisms which drive these processes and regulate behavioural output. The volume also includes chapters on pathological disturbances in motivation including apathy, or motivational deficit as well as addictions, the pathological misdirection of motivated behavior. As with the chapters on healthy motivational processes, the chapters on disease provide a comprehensive up to date review of the neurobiological abnormalities that underlie motivation, as determined by studies of patient populations as well as animal models of disease. The book closes with a section on recent developments in treatments for motivational disorders.

NMR Case Studies: Data Analysis of Complicated Molecules provides a detailed discussion of the full logical flow associated with assigning the NMR spectra of complex molecules, also helping readers further develop their NMR spectral assignment skills. The robust case studies present the logic of each assignment, from beginning to end, fully exploring the available range of potential solutions. Readers will gain a better appreciation of various approaches and develop an intuitive sense for when this particular concept should be implemented, thus enhancing their skillsets and providing a host of methodologies potentially amenable to yielding correct assignments. Authored by a scientist with more than 20 years of experience in research and instruction, this book is the ideal reference for anyone in search of application-based content. The book addresses complicated molecules, including corticosteroids, biomolecules, polypeptides, and secondary metabolites.

GENSTAT is a general purpose statistical computing system with a flexible command language operating on a variety of data structures. It may be used on a number of computer ranges, either interactively for exploratory data analysis, or in batch mode for standard data analysis.
The great flexibility of GENSTAT is demonstrated in this handbook by analysing the wide range of examples discussed in Applied Statistics - Principles and Examples (Cox and Snell, 1981). GENSTAT programs are listed for each of the examples. Most of the data sets are small but often it is these seemingly small problems which involve the most tricky statistical and computational procedures. This handbook is self-contained although for a full description of the analysis and interpretation it should be used in parallel with Applied Statistics - Principles and Examples.

Many patients come to the Accident and Emergency department in pain or with conditions requiring local or general anaesthesia. Close co-operation between the staff of the Anaesthesia and Accident and Emergency departments is vital if anaesthesia and analgesia are to be dealt with efficiently and safely. This new edition has been extensively revised throughout, especially with regard to resuscitation techniques. It provides a concise guide to anaesthesia and pain relief in emergency medicine. Throughout, the emphasis is on the practical management of problems, giving clear instructions about the treatment of common conditions.

In April 1861, Dick and Tally Simpson, sons of South Carolina Congressman Richard F. Simpson, enlisted in Company A of the Third South Carolina Volunteers of the Confederate army. Their letters home--published here for the first time--read like a historical novel, complete with plot, romance, character, suspense, and tragedy. In their last year of college when the war broke out, Dick and Tally were hastily handed their diplomas so they could volunteer for military duty. Dick was twenty; Tally was twenty-two.
Well educated, intelligent, and thoughtful young men, Dick and Tally cared deeply for their country, their family, and their comrades-in-arms and wrote frequently to their loved ones in Pendleton, South Carolina, offering firsthand accounts of dramatic events from the battle of First Manassas in July 1861 to the battle of Chickamauga in September 1863. Their letters provide a picture of war as it was actually experienced at the time, not as it was remembered some twenty or thirty years later. It is a picture that neither glorifies war nor condemns it, but simply "tells it like it is." Written to a number of different people, the boys' letters home dealt with a number of different subjects. Letters to "Pa" went into great detail about military matters in Lee's Army of Northern Virginia--troop movements, casualties, and how well particular units had fought; letters to "Ma" and sisters Anna and Mary were about camp life and family friends in the army and usually included requests for much-needed food and clothing; letters to Aunt Caroline and her daughter Carrie usually concerned affairs of the heart, for Aunt Caroline continued to be Dick and Tally's trusted confidante, even whenthey were "far, far from home."
The value of these letters lies not so much in the detailed information they provide as in the overall picture they convey--a picture of how one Southern family, for better or for worse, at home and at the front--coped with the experience of war. These are not wartime reminiscences, but wartime letters, written from the camp, the battlefield, the hospital bed, the picket line--wherever the boys happened to be when they found time to write home. It is a poignant picture of war as it was actually experienced in the South as the Civil War unfolded.
My dear Aunt
With pleasure do I attempt to scratch you a few lines. I have passed the line of sentinels and am now far out in the woods sitting on the ground writing with a pencil about long enough to ketch with two fingers and on a little piece of plank about as large as my paper, so you must excuse this scrawl....We are now in the land of danger, far, far from home, fighting for our homes and those near our hearts. I have been from home for months at a time, but I never wished to be back as bad in my life. How memory recalls every little spot, and how vividly every little scene flashes before my mind. Oh! if there is one place dear to me it is home sweet home. How many joys cluster there. To join once more our family circle (I mean you all) and talk of times gone by would be more to me than all else besides...your
Most affectionate nephew
R W S

In most patients, pain medication, along with physical therapy and supportive counselling, adequately controls the pain of terminal disease, but in some cases pain medication fails or produces unacceptable side effects, and other more invasive interventions may be used. This practical book provides comprehensive and easy-to-follow guidelines on nerve blocking and neuromodulation techniques to help patients and professionals make choices in pain management. Patients selection and appropriate referral are discussed as well as ethical issues and consent. This book will be an invaluable source of information for a variety of professionals working with patients with advanced disease, including palliative care doctors and specialist nurses, as there is a scarcity of consultants in pain management in the field of palliative care. Some healthcare professionals may not have experience of the full range of techniques that may benefit their patients, therefore limiting the choices available to patients with uncontrolled pain in the context of palliative care. This book will ensure that the full range of techniques are considered to provide excellent care for patients with pain that is difficult to manage.

Many patients come to the Accident and Emergency department in pain or with conditions requiring local or general anaesthesia. Close co-operation between the staff of the Anaesthesia and Accident and Emergency departments is vital if anaesthesia and analgesia are to be dealt with efficiently and safely. This new edition of Anaesthesia and Analgesia in Emergency Medicine has been extensively revised throughout, especially with regard to resuscitation techniques. It provides a concise guide to anaesthesia and pain relief in Emergency Medicine. Throughout, the emphasis is on the practical management of problems, giving clear instructions about the treatment of common conditions.

This volume covers the current status of research in the neurobiology of motivated behaviors in humans and other animals in healthy condition. This includes consideration of the psychological processes that drive motivated behavior and the anatomical, electrophysiological and neurochemical mechanisms which drive these processes and regulate behavioural output. The volume also includes chapters on pathological disturbances in motivation including apathy, or motivational deficit as well as addictions, the pathological misdirection of motivated behavior. As with the chapters on healthy motivational processes, the chapters on disease provide a comprehensive up to date review of the neurobiological abnormalities that underlie motivation, as determined by studies of patient populations as well as animal models of disease. The book closes with a section on recent developments in treatments for motivational disorders.

This new edition of the Practical Management of Complex Cancer Pain has been fully updated and expanded, with five new chapters on novel interventional techniques in cancer pain amelioration. The book provides advice on advanced pain management, emphasising the suitability and selection of patients for different invasive and complex procedures based on patient history. Case histories are included throughout the text to give the reader insight into the complexities of holistic management, with pain being only one component in the distress that cancer causes for both patients and families. The book also covers cancer pain management for patients in a community setting, and the collaboration between pain and palliative medicine. Concise, practical, and evidence-based, this guide is essential reading for all pain and palliative care specialists in the community, hospital, and hospice settings.

In this exciting and innovative textbook, two leading oceanographers bring together the fundamental physics and biology of the coastal ocean in a quantitative but accessible way for undergraduate and graduate students. Shelf sea processes are comprehensively explained from first principles using an integrated approach to oceanography that helps build a clear understanding of how shelf sea physics underpins key biological processes in these environmentally sensitive regions. Using many observational and model examples, worked problems and software tools, the authors explain the range of physical controls on primary biological production and shelf sea ecosystems. Boxes throughout the book present extra detail for each topic and non-mathematical summary points are provided for physics sections, allowing students to develop an intuitive understanding. The book is fully supported by extensive online materials, including worked solutions to end-of-chapter exercises, additional homework/exam problems with solutions and simple MATLAB and FORTRAN models for running simulations.

In this exciting and innovative textbook, two leading oceanographers bring together the fundamental physics and biology of the coastal ocean in a quantitative but accessible way for undergraduate and graduate students. Shelf sea processes are comprehensively explained from first principles using an integrated approach to oceanography that helps build a clear understanding of how shelf sea physics underpins key biological processes in these environmentally sensitive regions. Using many observational and model examples, worked problems and software tools, the authors explain the range of physical controls on primary biological production and shelf sea ecosystems. Boxes throughout the book present extra detail for each topic and non-mathematical summary points are provided for physics sections, allowing students to develop an intuitive understanding. The book is fully supported by extensive online materials, including worked solutions to end-of-chapter exercises, additional homework/exam problems with solutions and simple MATLAB and FORTRAN models for running simulations.

In 1849, the Corps of Topographical Engineers commissioned Lieutenant James H. Simpson to undertake the first survey of Navajo country in present-day New Mexico. Accompanying Simpson was a military force commanded by Colonel John M. Washington, sent to negotiate peace with the Navajo. A keen observer, Simpson kept a journal that provided valuable information on the party's interactions with Indians and also about the land's features, including important pueblo ruins at Chaco Canyon and Canyon de Chelly. His careful observations informed subsequent military expeditions, emigrant trains, the selection of Indian reservations, and the charting of a transcontinental railroad.

Editor Frank McNitt discusses the expedition's lasting importance to the development of the West, and his research is enriched by illustrations and maps by artists Richard and Edward Kern. Military historian Durwood Ball contributes a new foreword.

The Making of the Modern Law: Legal Treatises, 1800-1926 includes over 20,000 analytical, theoretical and practical works on American and British Law. It includes the writings of major legal theorists, including Sir Edward Coke, Sir William Blackstone, James Fitzjames Stephen, Frederic William Maitland, John Marshall, Joseph Story, Oliver Wendell Holmes, Jr. and Roscoe Pound, among others. Legal Treatises includes casebooks, local practice manuals, form books, works for lay readers, pamphlets, letters, speeches and other works of the most influential writers of their time. It is of great value to researchers of domestic and international law, government and politics, legal history, business and economics, criminology and much more.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++Harvard Law School LibraryCTRG95-B3736Includes index.London: Stevens and Haynes, 1909. civ, 478 p. 26 cm

The Making of the Modern Law: Legal Treatises, 1800-1926 includes over 20,000 analytical, theoretical and practical works on American and British Law. It includes the writings of major legal theorists, including Sir Edward Coke, Sir William Blackstone, James Fitzjames Stephen, Frederic William Maitland, John Marshall, Joseph Story, Oliver Wendell Holmes, Jr. and Roscoe Pound, among others. Legal Treatises includes casebooks, local practice manuals, form books, works for lay readers, pamphlets, letters, speeches and other works of the most influential writers of their time. It is of great value to researchers of domestic and international law, government and politics, legal history, business and economics, criminology and much more.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++Harvard Law School Libraryocm16719351Includes index.London: Stevens and Haynes, 1875. liii, 571 p.; 23 cm.