Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid-based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.

This book introduces the methods for predicting the future behavior of a system's health and the remaining useful life to determine an appropriate maintenance schedule. The authors introduce the history, industrial applications, algorithms, and benefits and challenges of PHM (Prognostics and Health Management) to help readers understand this highly interdisciplinary engineering approach that incorporates sensing technologies, physics of failure, machine learning, modern statistics, and reliability engineering. It is ideal for beginners because it introduces various prognostics algorithms and explains their attributes, pros and cons in terms of model definition, model parameter estimation, and ability to handle noise and bias in data, allowing readers to select the appropriate methods for their fields of application.Among the many topics discussed in-depth are:* Prognostics tutorials using least-squares* Bayesian inference and parameter estimation* Physics-based prognostics algorithms including nonlinear least squares, Bayesian method, and particle filter* Data-driven prognostics algorithms including Gaussian process regression and neural network* Comparison of different prognostics algorithms The authors also present several applications of prognostics in practical engineering systems, including wear in a revolute joint, fatigue crack growth in a panel, prognostics using accelerated life test data, fatigue damage in bearings, and more. Prognostics tutorials with a Matlab code using simple examples are provided, along with a companion website that presents Matlab programs for different algorithms as well as measurement data. Each chapter contains a comprehensive set of exercise problems, some of which require Matlab programs, making this an ideal book for graduate students in mechanical, civil, aerospace, electrical, and industrial engineering and engineering mechanics, as well as researchers and maintenance engineers in the above fields.

Elementary Particles and Their Interactions. Concepts and Phenomena presents a well-written and thorough introduction to this field at the advanced undergraduate and graduate level. Students familiar with quantum mechanics, special relativity and classical electrodynamics will find easy access to modern particle physics and a rich source of illustrative examples, figures, tables, and problems with selected solutions. Further references guide the reader through the literature. This text should become a standard reference to particle physics and will be useful to students and lecturers alike.

Extensive numerical methods for computing design sensitivity are included in the text for practical application and software development. The numerical method allows integration of CAD-FEA-DSA software tools, so that design optimization can be carried out using CAD geometric models instead of FEA models. This capability allows integration of CAD-CAE-CAM so that optimized designs can be manufactured effectively.

Extensive numerical methods for computing design sensitivity are included in the text for practical application and software development. The numerical method allows integration of CAD-FEA-DSA software tools, so that design optimization can be carried out using CAD geometric models instead of FEA models. This capability allows integration of CAD-CAE-CAM so that optimized designs can be manufactured effectively.

This book presents comprehensive studies of charge density waves (CDW) in a high-Tc cuprate superconductor using x-ray scattering techniques under uniaxial pressure. Specifically, the work addresses inelastic x-ray scattering studies under uniaxial pressure performed on the underdoped cuprate YBa2Cu3O6.67(p=0.12, Tc=65K) with incoming photon energy in the resonant (E=931.3 eV, Cu-L3 edge) and non-resonant conditions (E=17.794 keV). This is a completely new approach to the investigation of charge density waves. It revealed new features of charge density waves in cuprates, whose properties had previously been inaccessible..

This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell-cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein-carbohydrate or carbohydrate-carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.

This graduate-level textbook is a tutorial for item response theory that covers both the basics of item response theory and the use of R for preparing graphical presentation in writings about the theory. Item response theory has become one of the most powerful tools used in test construction, yet one of the barriers to learning and applying it is the considerable amount of sophisticated computational effort required to illustrate even the simplest concepts. This text provides the reader access to the basic concepts of item response theory freed of the tedious underlying calculations. It is intended for those who possess limited knowledge of educational measurement and psychometrics. Rather than presenting the full scope of item response theory, this textbook is concise and practical and presents basic concepts without becoming enmeshed in underlying mathematical and computational complexities. Clearly written text and succinct R code allow anyone familiar with statistical concepts to explore and apply item response theory in a practical way. In addition to students of educational measurement, this text will be valuable to measurement specialists working in testing programs at any level and who need an understanding of item response theory in order to evaluate its potential in their settings.

This volume includes "Divide and Edit: A Brief History of Book Divisions" by Carolyn Higbie; "Aristotle's Hamartia Reconsidered" by Ho Kim; "Callimachus and his Allusive Virgins" by Andrew Faulkner; "Theokritos' Idyll 16: The Kharites and Civic Poetry" by Jose Gonzalez; "Boxing and Sacrifice in Epic: Apollonius, Vergil, and Valerius" by Matthew Leigh; "The Rhodian Loss of Caunus and Stratonicea in the 160s" by Sviatoslav Dmitriev; "Trina tempestas (Carmina Einsidlensia 2.33)" by Radoslaw Pietka; "The Vanishing Gardens of Priapus" by James Uden; "Trimalchio and Fortunata as Zeus and Hera" by Maria Ypsilanti; "Ps.-Dionysius on Epideictic Rhetoric: Seven Chapters, or One Complete Treatise?" by Martin Korenjak; "The Grammarian C. Iulius Romanus and the Fabula Togata" by Jarrett T. Welsh; "Quintus of Smyrna and the Second Sophistic" by Silvio Bar; and "The Conversion of A. D. Nock in the Context of His Life, Scholarship, and Religious View" by Simon Price.

This book brings Korea's finest foreign policy minds together in contemplating the risks and rewards of finally ending the 70 year stalemate between North and South Korea through reunification. While North Korea is in conflict with the United States over denuclearization and regime security, the South Korean government is focusing on economic development preparing for the day when the two Koreas are unified. This book will help scholars, activists and policy-makers from all over the world systematically understand the current diplomatic and security issues in the Korean peninsula.

This book is an in-depth interpretation of Max Weber as a political theorist of civil society. On the one hand, it reads Weber's ideas from the perspective of modern political thought, rather than the modern social sciences; on the other, it offers a liberal assessment of this complex political thinker without attempting to apologize for his shortcomings. Through an alternative reading of Weber's religious, epistemological and political writings, the book shows Weber's concern with public citizenship in a modern mass democracy and civil society as its cultivating ground. Kim argues Weber's political thought, thus recast, was deeply informed by Kant, Hegel, Nietzsche and other German political thinkers and also reveals an affinity to the liberal-republican tradition best represented by Mill and Tocqueville. Kim has effectively resuscitated Weber as a political thinker for our time in which civic virtues and civil society have once again become one of the dominant issues.

This book introduces the key concepts of nonlinear finite element analysis procedures. The book explains the fundamental theories of the field and provides instructions on how to apply the concepts to solving practical engineering problems. Instead of covering many nonlinear problems, the book focuses on three representative problems: nonlinear elasticity, elastoplasticity, and contact problems. The book is written independent of any particular software, but tutorials and examples using four commercial programs are included as appendices: ANSYS, NASTRAN, ABAQUS, and MATLAB. In particular, the MATLAB program includes all source codes so that students can develop their own material models, or different algorithms. Please visit the author's website for supplemental material, including PowerPoint presentations and MATLAB codes, at http://www2.mae.ufl.edu/nkim/INFEM/

Item Response Theory clearly describes the most recently developed IRT models and furnishes detailed explanations of algorithms that can be used to estimate the item or ability parameters under various IRT models. Extensively revised and expanded, this edition offers three new chapters discussing parameter estimation with multiple groups, parameter estimation for a test with mixed item types, and Markov chain Monte Carlo methods. It includes discussions on issues related to statistical theory, numerical methods, and the mechanics of computer programs for parameter estimation, which help to build a clear understanding of the computational demands and challenges of IRT estimation procedures.

North Korean Foreign Policy: Security Dilemma and Succession, by Yongho Kim, starts from the point of view that North Korea's provocations have been motivated more by fear than by her in-born provocative nature. Kim argues that North Korea's provocative foreign policy reflects its threat perception stemming from various security dilemma, and a very real concern regarding another father-to-son succession. This volume views North Korea's external and domestic threats as causes and its provocative foreign policy as an effect of the causes. The security dilemma has impelled North Korea to generate and thus portray to the world provocative signals, and the ever-pressing issue of Kim Jong-il's succession has driven him to prioritize his own political survival over that of North Korea's state survival. Unless Kim Jong-il's political survival is guaranteed, North Korea will not be interested in full-scale introduction of capitalist way of economic reform and economic package promised by the United States and South Korea in return for the abandonment of their nuclear program. North Korean Foreign Policy suggests that an effective policy for countries relating to North Korea, whether dovish or hawkish, should deal directly with Kim Jong-il's political survival, and not with Pyongyang's failed economy.

Item Response Theory clearly describes the most recently developed IRT models and furnishes detailed explanations of algorithms that can be used to estimate the item or ability parameters under various IRT models. Extensively revised and expanded, this edition offers three new chapters discussing parameter estimation with multiple groups, parameter estimation for a test with mixed item types, and Markov chain Monte Carlo methods. It includes discussions on issues related to statistical theory, numerical methods, and the mechanics of computer programs for parameter estimation, which help to build a clear understanding of the computational demands and challenges of IRT estimation procedures.

This completely revised second edition of our hugely popular book invites the reader to explore ten of the most important areas of modern physics: Symmetry, Lasers, Superconductivity, Bose-Einstein Condensation, Nanoscience, Quantum Computation, Chaos and Fractals, Stellar Evolution, Particles, and Cosmology.The new edition adds three new chapters in about a third of the book, covering the latest, hottest topics in contemporary physics: Bose-Einstein Condensate: Where Many Become One and How to Get There: Bose Statistics: Counting of the Indistinguishables; Bose-Einstein Condensation (BEC): The Over-Population Crisis; Cooling and Trapping of Atoms: Towards BEC; Doppler Limit and its Break Down; Trapping of Cold Atoms: Magnetic and Magneto-Optic Trap; Evaporative Cooling; BEC Finally: But How do We Know?; BEC: What Good is it? Exploring Nanostructures: Towards the Bottom; The Rise of Nanoscience; Confined Systems; Quantum Devices; The Genius of Carbon; Spintronics; Nanos at Large. Quantum Computation and Information: Classical Computer; Quantum Computer; Quantum Gates; Deutsch's Algorithm; Finding the Period of a Function; Shor's Factorization Algorithm; Grover's Search Algorithm; Hardware and Error Correction; Cryptography; Quantum Teleportation.The authors give a fascinating, up-to-date account of the exciting advances in these fast-moving fields. Their emphasis is as much on describing natural phenomena as on attempting to explain them in terms of basic principles, replacing equations with physical insight. General readers and university undergraduates alike will find this unique book a useful guide to the worlds of modern physics, while the mature scientist will get an insightful survey of neighboring fields of research. For the teacher who takes a thematic approach to teaching physics, this book will be a complete source of current topics at the frontiers of research; and for the student, a valuable tool of study, made even more useful by numerous pertinent problems (with complete solutions) and references found at the end of each chapter.

This completely revised second edition of our hugely popular book invites the reader to explore ten of the most important areas of modern physics: Symmetry, Lasers, Superconductivity, Bose-Einstein Condensation, Nanoscience, Quantum Computation, Chaos and Fractals, Stellar Evolution, Particles, and Cosmology.The new edition adds three new chapters in about a third of the book, covering the latest, hottest topics in contemporary physics: Bose-Einstein Condensate: Where Many Become One and How to Get There: Bose Statistics: Counting of the Indistinguishables; Bose-Einstein Condensation (BEC): The Over-Population Crisis; Cooling and Trapping of Atoms: Towards BEC; Doppler Limit and its Break Down; Trapping of Cold Atoms: Magnetic and Magneto-Optic Trap; Evaporative Cooling; BEC Finally: But How do We Know?; BEC: What Good is it? Exploring Nanostructures: Towards the Bottom; The Rise of Nanoscience; Confined Systems; Quantum Devices; The Genius of Carbon; Spintronics; Nanos at Large. Quantum Computation and Information: Classical Computer; Quantum Computer; Quantum Gates; Deutsch's Algorithm; Finding the Period of a Function; Shor's Factorization Algorithm; Grover's Search Algorithm; Hardware and Error Correction; Cryptography; Quantum Teleportation.The authors give a fascinating, up-to-date account of the exciting advances in these fast-moving fields. Their emphasis is as much on describing natural phenomena as on attempting to explain them in terms of basic principles, replacing equations with physical insight. General readers and university undergraduates alike will find this unique book a useful guide to the worlds of modern physics, while the mature scientist will get an insightful survey of neighboring fields of research. For the teacher who takes a thematic approach to teaching physics, this book will be a complete source of current topics at the frontiers of research; and for the student, a valuable tool of study, made even more useful by numerous pertinent problems (with complete solutions) and references found at the end of each chapter.

Invisible is a book on St. Louis design practice, Axi:Ome led by Heather Woofter and Sung Ho Kim. A collection of essays, built, unbuilt and conceptual projects which maps the trajectory of the last seven years of work from 2015 through 2022. The book covers 24 projects in different cultures and landscapes around the world with various programs and scales. Nader Tehrani, Eric Mumford, Alan Balfour, Jennifer Yoos, Nanako Umemoto, and Jessie Reiser provide insightful texts supporting and articulating critical frameworks of Axi:Ome, while defining a discourse of complexities in contemporary practice that is emerging from academic expectations. The book documents the invisible ethos that constructs a project in an intricate world that challenges practitioners to re-think and re-examine how they position into architectural spectrum. Invisible cartographs and chronicles the legitimisation of architectural practice that engages the pedagogical visions of the profession and the education.

This book presents comprehensive studies of charge density waves (CDW) in a high-Tc cuprate superconductor using x-ray scattering techniques under uniaxial pressure. Specifically, the work addresses inelastic x-ray scattering studies under uniaxial pressure performed on the underdoped cuprate YBa2Cu3O6.67(p=0.12, Tc=65K) with incoming photon energy in the resonant (E=931.3 eV, Cu-L3 edge) and non-resonant conditions (E=17.794 keV). This is a completely new approach to the investigation of charge density waves. It revealed new features of charge density waves in cuprates, whose properties had previously been inaccessible..

This book presents the latest knowledge and the most recent research results on glycosphingolipid (GSL)-mediated signaling. GSLs are important constituents of the plasma membrane that exert their distinct functions through binding to certain functional proteins. They play a role in various human diseases and also function as human alloantigens. Cellular GSLs are associated with many biological functions such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell-cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein-carbohydrate or carbohydrate-carbohydrate interactions. This book opens by providing the key background on GSL glycan-receptor interactions and mammalian GSL synthesis. Up-to-date information is then presented on all aspects of GSL-dependent signaling. Viral protein and bacterial toxin protein interactions with host cell GSLs are examined in depth, and the concluding chapter is devoted to signaling regulation. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.

This book is an in-depth interpretation of Max Weber as a political theorist of civil society. On the one hand, it reads Weber's ideas from the perspective of modern political thought, rather than the modern social sciences; on the other, it offers a liberal assessment of this complex political thinker without attempting to apologize for his shortcomings. Through an alternative reading of Weber's religious, epistemological and political writings, the book shows Weber's concern with public citizenship in a modern mass democracy and civil society as its cultivating ground. Kim argues Weber's political thought, thus recast, was deeply informed by Kant, Hegel, Nietzsche and other German political thinkers and also reveals an affinity to the liberal-republican tradition best represented by Mill and Tocqueville. Kim has effectively resuscitated Weber as a political thinker for our time in which civic virtues and civil society have once again become one of the dominant issues.