In Performatively Speaking, Debra Rosenthal draws on speech act theory to open up the current critical conversation about antebellum American fiction and culture and to explore what happens when writers use words not just to represent action but to constitute action itself. Examining moments of discursive action in a range of canonical and noncanonical works-T. S. Arthur's temperance tales, Fanny Fern's Ruth Hall, Nathaniel Hawthorne's The Scarlet Letter, Harriet Beecher Stowe's Uncle Tom's Cabin, and Herman Melville's Moby-Dick-she shows how words act when writers no longer hold to a difference between writing and doing. The author investigates, for example, the voluntary self-binding nature of a promise, the formulaic but transformative temperance pledge, the power of Ruth Hall's signature or name on legal documents, the punitive hate speech of Hester Prynne's scarlet letter A, the prohibitory vodun hex of Simon Legree's slave Cassy, and Captain Ahab's injurious insults to second mate Stubb. Through her comparative methodology and historicist and feminist readings, Rosenthal asks readers to rethink the ways that speech and action intersect.

Nanobiotechnology holds the promise of providing revolutionary insight into aspects biology ranging from fundamental questions such as elucidating molecular mechanisms of brain disorders to extraordinary applications such as the detection of a single cancer cell in a population of a million cells. The second edition of Nanobiotechnology Protocols expands upon the previous editions with current, detailed protocols for nanobiotechnology; imaging and detection. With new chapters that explore nano-bio constructs and toxicology of nanomaterials. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nanobiotechnology Protocol, Second Edition highlights important current areas of development and directions of the field for the future.

Hands-on experts in nanomaterial synthesis and application describe in detail the key experimental techniques currently employed in novel materials synthesis, dynamic cellular imaging, and biological assays. The author's emphasize diverse strategies to synthesize and functionalize the use of nanoparticles for biological applications. Additional chapters focus on the use of biological components (peptides, antibodies, and DNA) to synthesize and organize nanoparticles to be used a building block in larger assemblies. These new materials make it possible to image cellular processes for longer durations, leading to high throughput cellular-based screens for drug discovery, drug delivery, and diagnostic applications. Highlights include overview chapters on quantum dots and DNA nanotechnology, and cutting-edge techniques in the emerging nanobiotachnology arena.

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Charter schools have emerged as one of the central policy debates in U.S. education--and the Thomas B. Fordham Institute team has been a key participant in this debate since day one, both nationally and in Ohio. Despite President Obama's call for states to strengthen the charter sector and widen the options it provides to needy youngsters, established interests in education and politics oppose this disruption of the status quo. Ohio has struggled with these issues for more than a decade, struggles in which the authors of this book have played influential--and controversial--roles, including that of an actual authorizer of charter schools. They write from wide experience on the ground as well as extensive research and nationally-respected policy expertise.

The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has too often been unachievable and unaffordable outside of established bariatric centers, but such centers themselves usually have insufficient capacity and resources to cope with growing demand. This book aims to provide guidance and helpful tips and tricks on how to deal with obese patients within a general surgery setting. Epidemiology, organizational and logistical aspects, nursing issues, patient assessment, anesthesiology, and surgical practicalities are expertly covered in the opening chapters. Techniques of relevance to the general surgeon are described according to anatomic region, covering the head and neck; cardiothoracic and vascular system; upper and lower GI tract; pancreas, liver and adrenal glands; urinary tract and kidneys; the reproductive system; and the abdominal wall. Results achieved by bariatric surgery worldwide are reviewed, and the book closes with a chapter devoted to plastic and reconstructive surgery. The Globesity Challenge to General Surgery highlights a need for global rethinking on public health as regards resource allocation and patterns and standards of care, improving outcomes through greater affordability.

First published in book form in 1852, Uncle Tom's Cabin quickly became a bestseller, recognised as a powerful contribution to anti-slavery debates. After more than 150 years, it remains one of the most widely discussed works of American literature.
This Routledge Literary Sourcebook:
*examines the life and career of Harriet Beecher Stowe
*sets the novel within its cultural contexts and reprints related documents from the period
*surveys criticism of the book from publication to the present
*reprints extracts from reviews and key critical texts
*annotates crucial passages from the novel, linking them to the contextual and critical materials included elsewhere in the Sourcebook
*suggests directions for further reading.
Bringing together a wealth of material with clear critical commentary, Debra Rosenthal offers the ideal starting point for anyone beginning to study this crucial American novel.

The State You See uncovers a racial gap in the way the American government appears in people's lives. It makes it clear that public policy changes over the last fifty years have driven all Americans to distrust the government that they see in their lives, even though Americans of different races are not seeing the same kind of government.For white people, these policy changes have involved a rising number of generous benefits submerged within America's tax code, which taken together cost the government more than Social Security and Medicare combined. Political attention focused on this has helped make welfare and taxes more visible representations of government for white Americans. As a result, white people are left with the misperception that government does nothing for them, apart from take their tax money to spend on welfare. Distrust of government is the result. For people of color, distrust is also rampant but for different reasons. Over the last fifty years, America has witnessed increasingly overbearing policing and swelling incarceration numbers. These changes have disproportionately impacted communities of color, helping to make the criminal legal system a unique visible manifestation of government in these communities. While distrust of government emerges in both cases, these different roots lead to different consequences. White people are mobilized into politics by their distrust, feeling that they must speak up in order to reclaim their misspent tax dollars. In contrast, people of color are pushed away from government due to a belief that engaging in American elections will yield the same kind of unresponsiveness and violence that comes from interactions with the police. The result is a perpetuation of the same kind of racial inequality that has always been present in American democracy. The State You See is essential reading for anyone interested in understanding how the American government engages in subtle forms of discrimination and how it continues to uphold racial inequality in the present day.

Series Information:
Routledge Literary Sourcebooks

Nanobiotechnology holds the promise of providing revolutionary insight into aspects biology ranging from fundamental questions such as elucidating molecular mechanisms of brain disorders to extraordinary applications such as the detection of a single cancer cell in a population of a million cells. The second edition of Nanobiotechnology Protocols expands upon the previous editions with current, detailed protocols for nanobiotechnology; imaging and detection. With new chapters that explore nano-bio constructs and toxicology of nanomaterials. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nanobiotechnology Protocol, Second Edition highlights important current areas of development and directions of the field for the future.

The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has to date often been unachievable and unaffordable outside of established bariatric centers, but such centers themselves usually have insufficient capacity and resources to cope with the demand among the general population. This book therefore provides a wealth of guidance and helpful tips and tricks on how to deal with obese patients within a general surgery setting. Importantly, it highlights the need for global rethinking on public health as regards resource allocation and patterns and standards of care, with the ultimate goal of improving outcomes through greater affordability.

Hands-on experts in nanomaterial synthesis and application describe in detail the key experimental techniques currently employed in novel materials synthesis, dynamic cellular imaging, and biological assays. The author's emphasize diverse strategies to synthesize and functionalize the use of nanoparticles for biological applications. Additional chapters focus on the use of biological components (peptides, antibodies, and DNA) to synthesize and organize nanoparticles to be used a building block in larger assemblies. These new materials make it possible to image cellular processes for longer durations, leading to high throughput cellular-based screens for drug discovery, drug delivery, and diagnostic applications. Highlights include overview chapters on quantum dots and DNA nanotechnology, and cutting-edge techniques in the emerging nanobiotachnology arena.

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Increased intra abdominal pressure as used in laparoscopic surgery produces various changes in the human organism. This book provides surgeons and anesthesiologists with a complete overview on these changes and the consequences for the patient in the perioperative and postoperative period. Special emphasis is laid on the management of pneumoperitoneum related complications.

In the 1940s, Dora Tamana ran a day-care centre for children in a shack in Cape Town. She had no money for pencils and paper, but by writing words in the sand with a stick, she taught the children to read and write. This was only a small part of Dora's work. To improve the living conditions of her people, she organised demonstrations, planned campaigns against racism and distributed political newspapers. She was also a leading member of the SACP, ANC and a founder member of the Federation of South African Women. Dora was banned and jailed for her political work, but her beliefs have taken hold in South Africa's new democracy. Dora Tamana died in 1983. They Fought for Freedom tells the life stories of southern African leaders who struggled for freedom and justice. In spite of the important roles they played in the history of southern Africa, most of these leaders have been largely ignored by the history books. The series tells their stories in an entertaining manner, in clear language and aims to restore them to their rightful place in history.

Ways of the World explores cosmopolitanism as it emerged during the Restoration and the role theater played in both memorializing and satirizing its implications and consequences. Rooted in the Stuart ambition to raise the status of England through two crucial investments—global traffic, including the slave trade, and cultural sophistication—this intensified global orientation led to the creation of global mercantile networks and to the rise of an urban British elite who drank Ethiopian coffee out of Asian porcelain at Ottoman-inspired coffeehouses. Restoration drama exposed cosmopolitanism's most embarrassing and troubling aspects, with such writers as Joseph Addison, Aphra Behn, John Dryden, and William Wycherley dramatizing the emotional and ethical dilemmas that imperial and commercial expansion brought to light. Altering standard narratives about Restoration drama, Laura J. Rosenthal shows how the reinvention of theater in this period—including technical innovations and the introduction of female performers—helped make possible performances that held the actions of the nation up for scrutiny, simultaneously indulging and ridiculing the violence and exploitation being perpetuated. In doing so, Ways of the World reveals an otherwise elusive consistency between Restoration genres (comedy, tragedy, heroic plays, and tragicomedy), disrupts conventional understandings of the rise and reception of early capitalism, and offers a fresh perspective on theatrical culture in the context of the shifting political realities of seventeenth- and eighteenth-century Britain.

In a readable, informative style, (complete with twenty-five charts), Rosenthal takes a fresh look at the biblical prophecies concerning end-times events and helps us understand what impact they should have on our daily Christian lives.

Since its emergence in the late twentieth century, climate fiction--or cli-fi--has concerned itself as much with economic injustice and popular revolt as with rising seas and soaring temperatures. Indeed, with its insistent focus on redressing social disparities, cli-fi might reasonably be classified as a form of protest literature. As environmental crises escalate and inequality intensifies, literary writers and scholars alike have increasingly scrutinized the dual exploitations of the earth’s ecosystems and the socioeconomically disadvantaged. Cli-Fi and Class focuses on the representation of class dynamics in climate-change narratives. With fifteen essays on the intersection of the economic and the ecological--addressing works ranging from the novels of Joseph Conrad, Cormac McCarthy, and Octavia Butler to the film Black Panther and the Broadway musical Hadestown--this collection unpacks the complex ways economic exploitation impacts planetary well-being, and the ways climatic change shapes those inequities in turn.

Drawing on a close reading of nearly forty years' worth of personal letters and her will, and incorporating new archival material, Margaret Paston emerges from this study as the best example we have of how lay piety was negotiated and integrated into daily medieval life.

This anthology makes available for the first time a selection of narratives by and about prostitutes in the eighteenth century. These memoirs, some written by and some about eighteenth-century prostitutes, offer important insights into female experience and class and gender roles in the period. Portraying the lives of women in both success and hardship, written in voices ranging from repentant to bawdy, the memoirs show the complexity of the lives of the "nightwalkers." For eighteenth-century readers, as Laura Rosenthal writes in her introduction, these memoirs "offered sensual and sentimental journeys, glimpses into high life and low life, and relentless confrontations with the explosive power of money and the vulnerability of those without it." Offering a range of narratives from the conservative and reformist to the unabashedly libertine, this book provides a fascinating alternative look into eighteenth-century culture.

Since its emergence in the late twentieth century, climate fiction--or cli-fi--has concerned itself as much with economic injustice and popular revolt as with rising seas and soaring temperatures. Indeed, with its insistent focus on redressing social disparities, cli-fi might reasonably be classified as a form of protest literature. As environmental crises escalate and inequality intensifies, literary writers and scholars alike have increasingly scrutinized the dual exploitations of the earth’s ecosystems and the socioeconomically disadvantaged. Cli-Fi and Class focuses on the representation of class dynamics in climate-change narratives. With fifteen essays on the intersection of the economic and the ecological--addressing works ranging from the novels of Joseph Conrad, Cormac McCarthy, and Octavia Butler to the film Black Panther and the Broadway musical Hadestown--this collection unpacks the complex ways economic exploitation impacts planetary well-being, and the ways climatic change shapes those inequities in turn.

In diesem Band werden innovative Therapieformen in der Nephrologie, Hamatologie und Hypertonieforschung vorgestellt, insbesondere die Behandlungsfortschritte bei chronischen Nierenerkrankungen. Experten aus Forschung, Klinik und Praxis diskutieren charakteristische Therapiesubstanzen bei chronischen Nierenerkrankungen, weiterfuhrende Perspektiven der Therapie von Knochenstoffwechselstorungen durch den Einsatz von Biophosphonaten sowie die klinische Relevanz der Mikroalbuminurie zur Detektion von Nephropathien.