In Psychology and Human Performance in Space Programs: Research at the Frontier, leading space researchers from multiple fields of expertise summarize the recent growth of knowledge, the resulting tools and techniques, and the research still needed to protect humans in space. Making use of cutting-edge research and development related to composing, training, and supporting astronaut crews who will live and work together for future missions to Mars, this book examines the current practices of leaders in the field both at NASA and in academia. Presenting astronaut data alongside data from analogous extreme environments such as mission simulation habitats, this volume helpfully contrasts and compares to examine the lessons that can be learned from other approaches. Using the context of current International Space Station missions, the book discusses the influence of human factors and physiological health on individual and team job performance and social cohesion. With an overview of the physical and psychological hazards of space, and the challenges posed by conducting space-related applied psychology research, this volume uses the context of a long-duration Mars mission as a lens through which to discuss adaptation and resilience, technical and team training, technological advances related to working and living in space, and human interaction with onboard systems. Additionally, the book includes an essay from retired astronaut Clay Anderson on his experiences in space and thoughts on future missions to the moon and Mars. This first of two volumes will be of interest to professionals in the field of human factors and psychology at work, as well as academics examining human performance in extreme environments and aerospace.

In Psychology and Human Performance in Space Programs: Extreme Application, operations experts from multiple space agencies, with support from spaceflight researchers, outline existing and proposed operations for selecting, training, and supporting space crews who currently live and work on the International Space Station, and who are preparing for future missions to the moon and Mars. Highlighting applied psychology in spaceflight whilst acknowledging real-world complexities that occur when integrating across an international, multi-agency collective, this volume provides both historical and current perspectives toward spaceflight operations, with expert contributions from NASA and international partners such as the Japanese Space Agency, Russian space researchers, and the Canadian Space Agency. Helpfully outlining the progress that has been made so far, this book includes topics such as the selection and hiring of astronauts, the process of training a crew for a mission to Mars, and workload and mission planning. Discussing operational psychology in space and on the ground, this book looks to the future of research and operational needs for future missions to Mars, with an essay from astronaut Dr. Don Pettit on his experiences in space and how the Mars mission will challenge us in new ways. This second of two volumes will be of interest to professionals in the field of human factors and psychology in extreme environments.

MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.

This two-volume set covers organizational psychology and human factors in aerospace and other extreme environments. Organizational psychology and organizational science, human factors, psychology, and aerospace have matured in parallel since World War II. However, the practice at NASA has historically lagged behind, but is now catching up. This set is targeted at professionals with an interest in human factors and psychology at work. Industrial-organizational psychologists will be exposed to traditional applied psychology topics, but presented with a broader multidisciplinary context such as the influences of human factors and physiological health on individual and team job performance.

Introduces all of the essential cell biology and developmental biology background for the study of stem cells This book gives you all the important information you need to become a stem cell scientist. It covers the characterization of cells, genetic techniques for modifying cells and organisms, tissue culture technology, transplantation immunology, properties of pluripotent and tissue specific stem cells and, in particular, the relevant aspects of mammalian developmental biology. It dispels many misconceptions about stem cells--especially that they can be miracle cells that can cure all ills. The book puts emphasis on stem cell behavior in its biological context and on how to study it. Throughout, the approach is simple, direct, and logical, and evidence is given to support conclusions. Stem cell biology has huge potential for advancing therapies for many distressing and recalcitrant diseases, and its potential will be realized most quickly when as many people as possible have a good grounding in the science of stem cells. Content focused on the basic science underpinning stem cell biology Covers techniques of studying cell properties and cell lineage in vivo and in vitro Explains the basics of embryonic development and cell differentiation, as well as the essential cell biology processes of signaling, gene expression, and cell division Includes instructor resources such as further reading and figures for downloading Offers an online supplement summarizing current clinical applications of stem cells Written by a prominent leader in the field, The Science of Stem Cells is an ideal course book for advanced undergraduates or graduate students studying stem cell biology, regenerative medicine, tissue engineering, and other topics of science and biology.

Pulse Detonation Engines (PDE) operating on liquid hydrocarbon fuels are limited to operating frequencies of 35 Hz due to long ignition times from low energy ignition sources. This study shows ignition time of JP-8 can be nearly eliminated by igniting a thrust tube using a secondary detonation. A counter flow heat exchanger attached to a thrust tube utilized waste heat from the detonation process to heat JP-8 to supercritical conditions. The fuel flash vaporized upon injection into the air stream of the engine, where a detonation was produced by a spark in a 5 cm diameter, 1.37 m long tube. Part of the detonation produced in the spark ignited tube was branched through a 1.9 cm diameter crossover tube into the head of second thrust tube. A pressure transducer and hydroxyl (OH) sensor measured the combustion event that determined ignition time of the second tube was eliminated. Branch detonation was performed over a range of equivalence ratios ranging from 1.05 to 1.3. Branch ignited thrust tubes have shown a 40% improvement in deflagration to detonation transition (DDT) time and a slight improvement in DDT distance.

This is a pre-1923 historical reproduction that was curated for quality. Quality assurance was conducted on each of these books in an attempt to remove books with imperfections introduced by the digitization process. Though we have made best efforts - the books may have occasional errors that do not impede the reading experience. We believe this work is culturally important and have elected to bring the book back into print as part of our continuing commitment to the preservation of printed works worldwide.