MicroRNAs have recently emerged as key regulators of gene
expression during development and are frequently misexpressed in
human disease states, in particular cancer. These
22-nucleotide-long transcripts act to promote or repress cell
proliferation, migration and apoptosis during development, all of
which are processes that go awry in cancer. Thus, microRNAs have
the ability to behave like oncogenes or tumor suppressors. In
addition, their small size and molecular properties make them
amenable as targets and therapeutics in cancer treatment. This book
goes into detail on how microRNAs represent a paradigm shift in
thinking about gene regulation during development and disease, and
provide the oncologist with a potentially powerful new battery of
agents to diagnose and treat cancer.
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