Current problems associated with the mycotoxicoses include the recognition of an animal disease as being a mycotoxicosis and confirmation of diagnosis of the mycotoxicosis by satisfactory laboratory methods. By gathering a vast amount of scientific literature, diagnosticians can provide themselves with suitable informa tion for making such a diagnosis. However, the increased number of reported intoxications caused by fungi, the wide range in diversity of disease conditions and the chemical compounds causing the mycotoxicoses, and the ever-changing and rapid developments in the technology of mycotoxin analysis has made the gathering and assimilation of sufficient information by the diagnostician an insurmountable task. This is the reason for development of the symposium and the publication of this book; the first time that the subject of diagnosis of mycotoxicoses has been assembled in a single publication and as a compilation of topic papers by experts in this subject area. The UJNR panel on toxic microorganisms is interested in all aspects of intox ications by microorganisms as evidenced by its annual joint meetings in either the United States or Japan and its involvement in sponsoring numerous symposia and several publications in this broad scientific area. The overall mission of the National Animal Disease Center includes research efforts in the improvement or establishment of diagnostic methods for animal diseases. The UJNR panel and the NADC provided the funds and encouragement for the development of a symposium on the diagnosis of mycotoxicoses in the United States and . Tapan."

Although toxigenic fungi have been known since ancient times, modern mycotoxinology probably began with the early work of Joseph Forgacs and his colleagues in the 1950s. This science grew tremendously with the discovery of aflatoxins and aflatoxicoses in the early 1960s, particulorly following the finding of the carcinogenicity of aflatoxins in test animol species. The discovery and identification of new mycotoxins and mycotoxi- coses, development of analytical procedures, attempted measurement of human and animal exposure, evaluation of toxicological effects, estimotiol' of risk due to human exposure, and development of regulatory control programs have been the major research goals over the past 30 years. In recent years there has also been an explosive growth in our knowledge of the metabolites produced by the algae, especially the dinoflagellate-produced toxins, and the transmission of such toxins up ~,e food chain to reef fish and shellfish. This knowledge has been invalualdl' in understanding and controlling human illness resulting from ingestion of seafood. We are now, for the first time, able to deal with such common seafood-related human diseases as paralytic, neurotoxic and amnesic shellfish and ciguatera poisoning.

This book was published for the Bicentennial Celebration of the Grand Lodge of Ancient Free and Accepted Masons of Delaware that was formed in 1806. It covers primarily events and activities for the last 50 years because in 1956 Brother Charles E. Green published a history of the first 150 years. However, there is information for the reader in this publication prior to 1956, e.g. Grand Master pictures and Blue Lodge information and building pictures. The reader will be interested in the various Grand Lodge changes over the last 50 years as well as activities that Delaware Masons have organized or participated within Delaware or surrounding states. A Mason, either within Delaware or elsewhere, will enjoy reading about topics of interest regarding the Grand Lodge of Delaware, the Blue Lodges and other events that have occurred in the last 50 years. A non-mason will discover much about Freemasonry.