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Experts from The Jackson Laboratory and around the world provide
practical advice on everything from how to establish a colony to
where to go for specific mutations. Systematic Approach to
Evaluation of Mouse Mutations includes information on medical
photography, grafting procedures, how to map the genes and evaluate
the special biological characteristics of the mice.
Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.
The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. Systematic Approach to Evaluation of Mouse Mutations includes information on medical photography, grafting procedures, how to map the genes and evaluate the special biological characteristics of the mice.
While mice have always been highly popular laboratory subjects,
their suitability for genetic engineering has solidified their
position as today's lab animal model of choice. However, their
increased use in genetic studies has created a demand for input on
phenotyping that is not always easily met. To improve the flow of
information on the pathology of mice with spontaneous or
genetically engineered mutations, prominent researchers organized a
series of meetings. Recognizing other needs, the organizers
gradually broadened their focus, until finally they expanded to
provide an overview of the entire field of genetically engineered
models. The Genetically Engineered Mice Handbook is an extension of
those meetings. It offers an introduction for those entering into
this area of research, while also serving as a resource for those
presently employing mice as laboratory models. Highly
comprehensive, this volume covers pertinent aspects of genetically
engineered mice, including the use of models for developmental
biology and the monitoring of laboratory colonies. With
contributions from nearly five-dozen leading researchers, the text
presents systematic approaches for analyzing mutant mice for
specific medical applications, details a variety of methods for
creating mutants and includes information that is particularly hard
to access dealing with legal responsibilities. This essential
reference examines commonly used traditional, as well as emerging,
technologies To address the purpose of the original meeting, the
Genetically Engineered Mice Handbook directs researchers to the
best public websites, and offers instruction on how to use them. In
the past, as their work dictated, researchers would seek out
experts on particular organ systems. Now groups of experts work
together to generate these websites, providing the latest data as
well as discussions over points of debate. These sites do not
eliminate the need for a trained pathologist, but they do provide
reference materials for those lacking expertise in particular
anatomic structures. They also offer much greater numbers of
examples than are available in print, from which biomedical
researchers can draw.
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