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Genetically Engineered Mice Handbook (Hardcover)
Loot Price: R5,642
Discovery Miles 56 420
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Genetically Engineered Mice Handbook (Hardcover)
Series: Research Methods For Mutant Mice
Expected to ship within 12 - 17 working days
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While mice have always been highly popular laboratory subjects,
their suitability for genetic engineering has solidified their
position as today's lab animal model of choice. However, their
increased use in genetic studies has created a demand for input on
phenotyping that is not always easily met. To improve the flow of
information on the pathology of mice with spontaneous or
genetically engineered mutations, prominent researchers organized a
series of meetings. Recognizing other needs, the organizers
gradually broadened their focus, until finally they expanded to
provide an overview of the entire field of genetically engineered
models. The Genetically Engineered Mice Handbook is an extension of
those meetings. It offers an introduction for those entering into
this area of research, while also serving as a resource for those
presently employing mice as laboratory models. Highly
comprehensive, this volume covers pertinent aspects of genetically
engineered mice, including the use of models for developmental
biology and the monitoring of laboratory colonies. With
contributions from nearly five-dozen leading researchers, the text
presents systematic approaches for analyzing mutant mice for
specific medical applications, details a variety of methods for
creating mutants and includes information that is particularly hard
to access dealing with legal responsibilities. This essential
reference examines commonly used traditional, as well as emerging,
technologies To address the purpose of the original meeting, the
Genetically Engineered Mice Handbook directs researchers to the
best public websites, and offers instruction on how to use them. In
the past, as their work dictated, researchers would seek out
experts on particular organ systems. Now groups of experts work
together to generate these websites, providing the latest data as
well as discussions over points of debate. These sites do not
eliminate the need for a trained pathologist, but they do provide
reference materials for those lacking expertise in particular
anatomic structures. They also offer much greater numbers of
examples than are available in print, from which biomedical
researchers can draw.
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