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Natural Products, Volume 61: Karl-Heinz Altmann Natural Products, Volume 61
Karl-Heinz Altmann
R5,444 R4,556 Discovery Miles 45 560 Save R888 (16%) Ships in 12 - 19 working days

Natural Products, Volume 61 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on Chemical evolution of natural product structure for drug discovery, Fungal Metabolites, Polypharmacology of Natural Products, Glycopeptide Antibiotics, and Natural products-based drug discovery for the CNS.

The Epothilones: An Outstanding Family of Anti-Tumor Agents - From Soil to the Clinic (Hardcover, 2009 ed.): Karl-Heinz Altmann The Epothilones: An Outstanding Family of Anti-Tumor Agents - From Soil to the Clinic (Hardcover, 2009 ed.)
Karl-Heinz Altmann; Series edited by A. Douglas Kinghorn; Edited by Johann H. Mulzer; Contributions by Gerhard Hoefle, Rolf Muller, …
R4,372 Discovery Miles 43 720 Ships in 10 - 15 working days

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

The Epothilones: An Outstanding Family of Anti-Tumor Agents - From Soil to the Clinic (Paperback, Softcover reprint of... The Epothilones: An Outstanding Family of Anti-Tumor Agents - From Soil to the Clinic (Paperback, Softcover reprint of hardcover 1st ed. 2009)
Karl-Heinz Altmann; Series edited by A. Douglas Kinghorn; Edited by Johann H. Mulzer; Contributions by Gerhard Hoefle, Rolf Muller, …
R4,342 Discovery Miles 43 420 Ships in 10 - 15 working days

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

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