The Epothilones: An Outstanding Family of Anti-Tumor Agents - From Soil to the Clinic (Hardcover, 2009 ed.)

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

General

Imprint:	Springer-Verlag
Country of origin:	Austria
Series:	Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products, 90
Release date:	June 2008
First published:	February 2009
Contributors:	Karl-Heinz Altmann
Series editors:	A. Douglas Kinghorn
Editors:	Johann H. Mulzer
Contributors:	Gerhard Hoefle • Rolf Muller • Kathrin Prantz
Dimensions:	235 x 155 x 15mm (L x W x T)
Format:	Hardcover
Pages:	260
Edition:	2009 ed.
ISBN-13:	978-3-211-78206-4
Categories:	Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-211-78206-0
Barcode:	9783211782064

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