Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design).

Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of cancer patients, and the risk of cancer recurrence in the rapidly increasing population of cancer survivors.
Since the first edition of this book was published in 1999, the idea that there is a single gene pathway or single drug will provide a cure for cancer has given way to the general view that dietary/environmental factors impact the progression of genetic and cellular changes in common forms of cancer. This broad concept can now be investigated within a basic and clinical research context for specific types of cancer. This book attempts to cover the current available knowledge in this new field of nutritional oncology written by invited experts. This book attempts to provide not only the theoretical and research basis for nutritional oncology, but will offer the medical oncologist and other members of multidisciplinary groups treating cancer patients practical information on nutrition assessment and nutritional regimens, including micronutrient and phytochemical supplementation. The editors hope that this volume will stimulate increased research, education and patient application of the principles of nutritional oncology.
NEW TO THIS EDITION:
* Covers hot new topics of nutrigenomics and nutrigenetics in cancer cell growth
* Includes new chapters on metabolic networks in cancer cell growth, nutrigenetics and nutrigenomics
* Presents substantially revised chapters on breast cancer and nutrition, prostate cancer and nutrition, and colon cancer and nutrition
* Includes new illustrations throughout the text, especially in the breast cancer chapter
* Includes integrated insights into the unanswered questions and clearly defined objectives of research in nutritional oncology
* Offers practical guidelines for clinicians advising malnourished cancer patients and cancer survivors on diet, nutrition, and lifestyle
* Provides information on the role of bioactive substances, dietary supplements, phytochemicals and botanicals in cancer prevention and treatment

What makes the Platinum English FAL course unique? Strong support for reading and writing skills, featuring annotations and models of all writing texts; integrated and explicit grammar teaching; predictable, consistent structure; high quality, relevant artwork; strong teacher support through explicit methods and assessment. Platinum - simply superior: Superior CAPS coverage and written by expert authors; superior illustrations and activities to improve results and motivate learners; superior teacher support to save time and make teaching easy, including photocopiable worksheets; superior quality = exam success!

This useful book reviews and analyzes the rigorous scientific, regulatory, and clinical testing and evaluation applied to the widely used food additive aspartame. In one compact volume you gain access to extensive information illustrating the increased recognition by regulatory agencies of the usefulness of human studies in evaluating new food additives. The Clinical Evaluation of a Food Additive: Assessment of Aspartame begins by describing the nuts and bolts of food additive safety evaluation in humans, including an insightful historical perspective of the development of good clinical practice guidelines. It provides the regulatory requirements for human research, as well as key elements for the design and conduct of human studies. The scientific and regulatory considerations of food additive safety are explored, including interesting descriptions of aspartame's key animal safety studies. In addition, the book reviews the medical postmarketing surveillance system developed for identifying and evaluating reports of aspartame's alleged adverse health effects. Through meticulous research and systematic clarity, The Clinical Evaluation of a Food Additive: Assessment of Aspartame provides work-saving, state-of-the-art examples to guide future testing and evaluation of tomorrow's food additives.

What makes the Platinum English FAL course unique? Strong support for reading and writing skills, featuring annotations and models of all writing texts; integrated and explicit grammar teaching; predictable, consistent structure; high quality, relevant artwork; strong teacher support through explicit methods and assessment. Platinum - simply superior: Superior CAPS coverage and written by expert authors; superior illustrations and activities to improve results and motivate learners; superior teacher support to save time and make teaching easy, including photocopiable worksheets; superior quality = exam success!

What makes the Platinum English first additional language course unique? Strong support for reading and writing skills, featuring annotations and models of all writing texts; integrated and explicit grammar teaching; predictable, consistent structure; high quality, relevant artwork; strong teacher support through explicit methods and assessment. Platinum! - Simply superior: superior CAPS coverage and written by expert authors; superior illustrations and activities to improve results and motivate learners; superior teacher support to save time and make teaching easy, including photocopiable worksheets. Superior quality = exam success!

Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design).

On August 19, 1958, Clara Luper and thirteen Black youth walked into Katz Drug Store in Oklahoma City and sat down at the lunch counter. When they tried to order, they were denied service. As they sat in silence, refusing to leave, the surrounding white customers unleashed a torrent of threats and racial slurs. This first organized sit-in in Oklahoma—almost two years before the more famous sit-ins in Greensboro, North Carolina—sparked other demonstrations in Oklahoma and other states. Behold the Walls is Luper’s engrossing firsthand account of how the movement she helped launch ended legal racial segregation. First published in 1979, Behold the Walls now features a new introduction and 33 newly selected historical photos. Luper’s direct, unvarnished account captures the immediacy of the events she witnessed. As a Black woman, Luper refused to let either her race or her gender deter her from stepping forth as a leader. Born in 1923, Clara Luper taught history in Oklahoma public schools and led the NAACP Youth Council. The students who sat in at Katz Drug and other businesses belonged to that organization. Luper highlights the contributions of others, especially young people, in breaking down the walls of segregation in Oklahoma through numerous demonstrations, marches, and voter registration campaigns. This commemorative edition of Luper’s eye-opening autobiography, published near what would have been her 100th birthday, as well as the 65th anniversary of the sit-ins, offers invaluable insight into the history of protest in the early years of the civil rights movement. With racial inequality still at the forefront of national debate, Behold the Walls places Luper’s efforts in the larger national context of the struggle to resist injustice and inspire positive change.

This volume explores basic and advanced aspects of our understanding of and current treatment for obesity. Contributors provide a multidisciplinary overview of this disease and offer practical guidance on state-of-the-art methods of assessment and treatment.;The first section of the book examines the disease of obesity and its metabolic consequences. It explores obesity in relation to physiological and psychological health, and describes the clinical aspects of properly evaluating obese patients. The roles of dietary factors, appetite, exercise, metabolism, and the endocrine system in obesity are discussed, as well as the effects of significant weight loss on long-term health. The psychology of obesity weight loss, and regain is also discussed.;The second section provides practitioners with detailed guidelines for selecting and implementing multidisciplinary treatment that incorporates dietary intervention, exercise, behaviour modification, and stress management, and, when necessary, surgery or pharmacotherapy. Matching patients with clinical interventions and treatment settings is emphasized, and strategies for maintaining weight loss are presented.;The final chapter illustrates how to design interventions appropriate for the hospital, physician's office, clinic, home, and workplace, and how to integrate different types of interventions in multiple settings.;Physicians, dietitians, psychiatrists, psychologists, exercise physiologists, and allied health professionals, as well as obesity researchers, should gain a broader understanding of the evaluation and treatment of obesity from this volume.

In April 2010, President Obama launched the America's Great Outdoors Initiative, calling on the Secretaries of the Departments of the Interior and Agriculture, the Administrator of the Environmental Protection Agency, and the Chair of the White House Council on Environmental Quality to develop a 21st-century conservation agenda that will protect America's natural and cultural resources, and connect people to the outdoors through jobs, education, recreation, and service. Conservation of our natural, cultural and historic resources is an American tradition, shaping who we are as a nation. This book highlights this Administration's work to date under the America's Great Outdoors (AGO) initiative.

Oklahoma was in the throes of the Great Depression when Preston George acquired a cheap Kodak folding camera and took his first photographs of steam locomotives. As depression gave way to world war, George kept taking pictures, now with a Graflex camera that could capture moving trains. In this first book devoted solely to George's work, his black-and-white photographs constitute a striking visual documentary of steam-driven railroading in its brief but glorious heyday in the American Southwest. The pictures also form a remarkable artistic accomplishment in their own right. Prominent among the magnificent action images collected here are the engines that were George's passion - steam locomotives pulling long freights or strings of gleaming passenger cars through open country. But along with the fireworks of the heavier steam engines slogging through the mountains near the Arkansas border on the Kansas City Southern or climbing Raton Pass in New Mexico on the Santa Fe, George's photographs also record humbler fare, such as the short trains of the Frisco and Katy piloted by ancient light steamers, and the final years of that state's interurban lines. Augustus J. Veenendaal Jr.'s brief history of railroads in the Sooner State puts these images into perspective, as does a reminiscence by George's daughter Burnis on his life and his pursuit of railroad photography. With over 150 images and a wealth of historical and biographical information, this volume makes accessible to an audience beyond the most avid railfans the extent of Preston George's extraordinary achievement.