WEGENER'S GRANULOMATOSIS & ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a "peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys". Later, Godman and Churg (1954) established the classical diagnostic criteria (the "WG triad"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported "limited forms" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome. The*latter experience led to the current "standard" treatment protocol (FAUCI et al. , 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al. , 1992).

As asymmetric 'wars among the people' replace state-on-state wars in modern armed conflict, the growing role of military medicine and medical technology in contemporary war fighting has brought an urgent need to critically reassess the theory and practice of military medical ethics. Military Medical Ethics for the 21st Century is the first full length, broad-based treatment of this important subject. Written by an international team of practitioners and academics, this book provides interdisciplinary insights into the major issues facing military-medical decision makers and critically examines the tensions and dilemmas inherent in the military and medical professions. In this book the authors explore the practice of battlefield bioethics, medical neutrality and treatment of the wounded, enhancement technologies for war fighters, the potential risks of dual-use biotechnologies, patient rights for active duty personnel, military medical research and military medical ethics education in the 21st Century.

Graph Theory and Its Applications, Third Edition is the latest edition of the international, bestselling textbook for undergraduate courses in graph theory, yet it is expansive enough to be used for graduate courses as well. The textbook takes a comprehensive, accessible approach to graph theory, integrating careful exposition of classical developments with emerging methods, models, and practical needs. The authors' unparalleled treatment is an ideal text for a two-semester course and a variety of one-semester classes, from an introductory one-semester course to courses slanted toward classical graph theory, operations research, data structures and algorithms, or algebra and topology. Features of the Third Edition Expanded coverage on several topics (e.g., applications of graph coloring and tree-decompositions) Provides better coverage of algorithms and algebraic and topological graph theory than any other text Incorporates several levels of carefully designed exercises that promote student retention and develop and sharpen problem-solving skills Includes supplementary exercises to develop problem-solving skills, solutions and hints, and a detailed appendix, which reviews the textbook's topics About the Authors Jonathan L. Gross is a professor of computer science at Columbia University. His research interests include topology and graph theory. Jay Yellen is a professor of mathematics at Rollins College. His current areas of research include graph theory, combinatorics, and algorithms. Mark Anderson is also a mathematics professor at Rollins College. His research interest in graph theory centers on the topological or algebraic side.

Volume 6: Ionization Methods

Volume 6 captures the story of molecular ionization and its phenomenal evolution that makes mass spectrometry the powerful method it is today. Chapters 1 and 2 cover fundamentals and various issues that are common to all ionization (e.g., accurate mass, isotope clusters, and derivatization).

Chapters 3-9 acknowledge that some ionization methods are appropriate for gas-phase molecules and others for molecules that are in the solid or liquid states. Chapters 3-6 cover gas-phase molecules, dividing the subject into: (1) ionization of gas-phase molecules by particles (e.g., EI), (2) ionization by photons, (3) ionization by ion-molecule and molecule-molecule reactions (e.g., APCI and DART), and ionization in Strong electric fields (i.e., Electrohydrodynamic and Field Ionization/Desorption).

"Ionization in a Strong Electric Field" illustrates the transition to ionization of molecules in the solid or liquid states, covered in Chapters 7-9: (1) spray methods for ionization (e.g., electrospray), (2) desorption ionization by particle bombardment (e.g., FAB), and (3) desorption by photons (e.g., MALDI). Electrospray and MALDI also lead to applications in biophysical chemistry, the theme of Chapter 10.

Chapter 11 reconsiders ionization from the view of choosing an ionization method. The range of subjects is from ionization of organic and biomolecules to the study of microorganisms.
* reviews range of ionization methods used in mass spectrometry today
* includes tutorials describing the principles and instrumentation applied to each method
* considers appropriate methods of ionization for analysis of various substances

Extensive exercises and applications. Flexibility: appropriate for either a first course at the graduate level; or an advanced course at the undergraduate level. Opens avenues to a variety of research areas in graph theory. Emphasis on topological and algebraic graph theory

As asymmetric 'wars among the people' replace state-on-state wars in modern armed conflict, the growing role of military medicine and medical technology in contemporary war fighting has brought an urgent need to critically reassess the theory and practice of military medical ethics. Military Medical Ethics for the 21st Century is the first full length, broad-based treatment of this important subject. Written by an international team of practitioners and academics, this book provides interdisciplinary insights into the major issues facing military-medical decision makers and critically examines the tensions and dilemmas inherent in the military and medical professions. In this book the authors explore the practice of battlefield bioethics, medical neutrality and treatment of the wounded, enhancement technologies for war fighters, the potential risks of dual-use biotechnologies, patient rights for active duty personnel, military medical research and military medical ethics education in the 21st Century.

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

The use of topological ideas to explore various aspects of graph theory, and vice versa, is a fruitful area of research. There are links with other areas of mathematics, such as design theory and geometry, and increasingly with such areas as computer networks where symmetry is an important feature. Other books cover portions of the material here, but there are no other books with such a wide scope. This book contains fifteen expository chapters written by acknowledged international experts in the field. Their well-written contributions have been carefully edited to enhance readability and to standardize the chapter structure, terminology and notation throughout the book. To help the reader, there is an extensive introductory chapter that covers the basic background material in graph theory and the topology of surfaces. Each chapter concludes with an extensive list of references.

Pragmatist thought is central to sociology. However, sociologists typically encounter pragmatism indirectly, as a philosophy of science or as an influence on canonical social scientists, rather than as a vital source of theory, research questions, and methodological reflection in sociology today. In The New Pragmatist Sociology, Neil Gross, Isaac Ariail Reed, and Christopher Winship assemble a range of sociologists to address essential ideas in the field and their historical and theoretical connection to classical pragmatism. The book examines questions of methodology, social interaction, and politics across the broad themes of inquiry, agency, and democracy. Essays engage widely and deeply with topics that motivate both pragmatist philosophy and sociology, including rationality, speech, truth, expertise, and methodological pluralism. Contributors include Natalie Aviles, Karida Brown, Daniel Cefai, Mazen Elfakhani, Luis Flores, Daniel Huebner, Cayce C. Hughes, Paul Lichterman, John Levi Martin, Ann Mische, Vontrese D. Pamphile, Jeffrey N. Parker, Susan Sibley, Daniel Silver, Mario Small, Iddo Tavory, Stefan Timmermans, Luna White, and Joshua Whitford.

Just war theory focuses primarily on bodily harm, such as killing, maiming, and torture, while other harms are often largely overlooked. At the same time, contemporary international conflicts increasingly involve the use of unarmed tactics, employing 'softer' alternatives or supplements to kinetic power that have not been sufficiently addressed by the ethics of war or international law. Soft war tactics include cyber-warfare and economic sanctions, media warfare, and propaganda, as well as non-violent resistance as it plays out in civil disobedience, boycotts, and 'lawfare.' While the just war tradition has much to say about 'hard' war - bullets, bombs, and bayonets - it is virtually silent on the subject of 'soft' war. Soft War: The Ethics of Unarmed Conflict illuminates this neglected aspect of international conflict.

WEGENER'S GRANULOMATOSIS & ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a "peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys". Later, Godman and Churg (1954) established the classical diagnostic criteria (the "WG triad"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported "limited forms" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome. The*latter experience led to the current "standard" treatment protocol (FAUCI et al. , 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al. , 1992).

Asymmetric conflict is changing the way that we practise and think about war. Torture, rendition, assassination, blackmail, extortion, direct attacks on civilians, and chemical weapons are all finding their way to the battlefield despite longstanding international prohibitions. This book offers a practical guide for policy makers, military officers, students, and others who ask such questions as: Do guerillas deserve respect or long jail sentences? Are there grounds to torture guerillas for information or assassinate them on the battlefield? Is there room for nonlethal weapons to subdue militants and safeguard the lives of noncombatants? Who are noncombatants in asymmetric war? What is the status of civilians who shelter and aid guerillas? And, do guerillas have any right to attack civilians, particularly those who aid and shelter members of the stronger army? If one side can expand the scope of civilian vulnerability, then why can t the other? To read and comment on Michael Gross's blog article on the UN Human Rights Council Report on Gaza, click here

Asymmetric conflict is changing the way that we practise and think about war. Torture, rendition, assassination, blackmail, extortion, direct attacks on civilians, and chemical weapons are all finding their way to the battlefield despite longstanding international prohibitions. This book offers a practical guide for policy makers, military officers, students, and others who ask such questions as: Do guerillas deserve respect or long jail sentences? Are there grounds to torture guerillas for information or assassinate them on the battlefield? Is there room for nonlethal weapons to subdue militants and safeguard the lives of noncombatants? Who are noncombatants in asymmetric war? What is the status of civilians who shelter and aid guerillas? And, do guerillas have any right to attack civilians, particularly those who aid and shelter members of the stronger army? If one side can expand the scope of civilian vulnerability, then why can t the other? To read and comment on Michael Gross's blog article on the UN Human Rights Council Report on Gaza, click here

Responsible citizens are expected to combine ethical judgement with judiciously exercised social activism to preserve the moral foundation of democratic society and prevent political injustice. But do they? Utilizing a research model integrating insights from rational choice theory and cognitive developmental psychology this book, first published in 1997, carefully explores three exemplary cases of morally inspired activism: Jewish rescue in wartime Europe, abortion politics in the United States, and peace and settler activism in Israel. From all three analyses a single conclusion emerges: the most politically competent individuals are, most often, the least morally competent. This is the central paradox of political morality. These findings cast doubt on strong models of political morality characterized by enlightened moral reasoning and concerted political action while affirming alternative weak models that fuse activism with sectarian moral interests. They provide empirical support to further upend the liberal vision of democratic character, education, and society.

The theory of Dirichlet forms has witnessed recently some very important developments both in theoretical foundations and in applications (stochasticprocesses, quantum field theory, composite materials, ...). It was therefore felt timely to have on this subject a CIME school, in which leading experts in the field would present both the basic foundations of the theory and some of the recent applications. The six courses covered the basic theory and applications to: - Stochastic processes and potential theory (M. Fukushima and M. Roeckner) - Regularity problems for solutions to elliptic equations in general domains (E. Fabes and C. Kenig) - Hypercontractivity of semigroups, logarithmic Sobolev inequalities and relation to statistical mechanics (L. Gross and D. Stroock). The School had a constant and active participation of young researchers, both from Italy and abroad.

Graph Theory and Its Applications, Third Edition is the latest edition of the international, bestselling textbook for undergraduate courses in graph theory, yet it is expansive enough to be used for graduate courses as well. The textbook takes a comprehensive, accessible approach to graph theory, integrating careful exposition of classical developments with emerging methods, models, and practical needs. The authors' unparalleled treatment is an ideal text for a two-semester course and a variety of one-semester classes, from an introductory one-semester course to courses slanted toward classical graph theory, operations research, data structures and algorithms, or algebra and topology. Features of the Third Edition Expanded coverage on several topics (e.g., applications of graph coloring and tree-decompositions) Provides better coverage of algorithms and algebraic and topological graph theory than any other text Incorporates several levels of carefully designed exercises that promote student retention and develop and sharpen problem-solving skills Includes supplementary exercises to develop problem-solving skills, solutions and hints, and a detailed appendix, which reviews the textbook's topics About the Authors Jonathan L. Gross is a professor of computer science at Columbia University. His research interests include topology and graph theory. Jay Yellen is a professor of mathematics at Rollins College. His current areas of research include graph theory, combinatorics, and algorithms. Mark Anderson is also a mathematics professor at Rollins College. His research interest in graph theory centers on the topological or algebraic side.

"Despite all the problems and oft-quoted risks in executing option transactions, I believe that there are enough benefits available to make option strategy a helpful tool for most investors."-from the Preface
Originally published almost a decade ago, LeRoy Gross's authoritative, yet highly accessible book has been the only resource available for conservative investors looking to further their investment goals with options. Now, with a new Introduction by the bestselling author Larry McMillan, The Conservative Investor's Guide to Trading Options has been updated to help market practitioners of the present garner the same rewards reaped by investors of the past.
Using the clear, balanced approach he used with his clients during a long career in the securities industry, Gross explores the various options strategies most frequently employed with individual stocks, examines the risk factors associated with each, and offers a unique perspective on how to use options as a hedging tool. From buy stock/write call to sell stock/buy call, the strategies covered are designed to help investors be better able to increase stock income, reduce stock risk, and seek stock profits. In addition to recommended systems, Gross also points out those that conservative investors should avoid, including naked call writing, calendar spread, and call option butterfly spread.
With clear, easy-to-understand explanations, here's where you'll find complete details on:
* Reading and understanding option tables
* Entering option orders
* Negotiating commission discounts
* Understanding the language of options trading with a complete glossary
Filled with practical examples andno-nonsense information, this is essential reading for all those who want to expand their portfolios using conservative option strategies.
A classic guide to safe and profitable options strategies for conservative investors-now updated
"Derivatives have become an important tool for an ever-increasing number of investors. The broad definition of 'derivatives' includes options, futures, and many more exotic instruments that are conjured up by the leading investment banks. For most stock-oriented investors, though, the term predominantly refers to stock options. The virtual explosion in trading of stock options attests to their importance. Still, there are many who do not yet understand what stock options are or how they can be of benefit to an investor. This book is for those investors."-from the Foreword by Larry McMillan

As insurgencies rage, a burning question remains: how should insurgents fight technologically superior state armies? Commentators rarely ask this question because the catchphrase 'we fight by the rules, but they don't' is nearly axiomatic. But truly, are all forms of guerrilla warfare equally reprehensible? Can we think cogently about just guerrilla warfare? May guerrilla tactics such as laying improvised explosive devices (IEDs), assassinating informers, using human shields, seizing prisoners of war, conducting cyber strikes against civilians, manipulating the media, looting resources, or using nonviolence to provoke violence prove acceptable under the changing norms of contemporary warfare? The short answer is 'yes', but modern guerrilla warfare requires a great deal of qualification, explanation, and argumentation before it joins the repertoire of acceptable military behavior. Not all insurgents fight justly, but guerrilla tactics and strategies are also not always the heinous practices that state powers often portray them to be.

As insurgencies rage, a burning question remains: how should insurgents fight technologically superior state armies? Commentators rarely ask this question because the catchphrase 'we fight by the rules, but they don't' is nearly axiomatic. But truly, are all forms of guerrilla warfare equally reprehensible? Can we think cogently about just guerrilla warfare? May guerrilla tactics such as laying improvised explosive devices (IEDs), assassinating informers, using human shields, seizing prisoners of war, conducting cyber strikes against civilians, manipulating the media, looting resources, or using nonviolence to provoke violence prove acceptable under the changing norms of contemporary warfare? The short answer is 'yes', but modern guerrilla warfare requires a great deal of qualification, explanation, and argumentation before it joins the repertoire of acceptable military behavior. Not all insurgents fight justly, but guerrilla tactics and strategies are also not always the heinous practices that state powers often portray them to be.