This book presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system-the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory-at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.
The book also includes an enlightening DVD describing the basic surface anatomy of the cerebral hemispheres, coronal and horizontal sections, and blunt dissection of the forebrain with special attention to clinical-anatomical correlations of interest to psychiatrists.
* A re-evaluation of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century
* A compellingly expanded conceptualization of Broca's famous limbic lobe
* Clinical and basic science boxes highlighting specific concepts, structures, or neuronal circuits from a clinical perspective
* DVD illustrating dissection of the human brain by one of the world's masters

Times of dramatic progress in brain research have often been correlated with the development of new and powerful techniques that have changed the kinds of questions one can ask. An historical example may illustrate the point. More than 50 years ago, Nissl studies (Ferraro, 1928) showed that extensive forebrain lesions resulted in chromatolysis and cell loss in the sub- stantia nigra; thus, it was suggested that the substantia nigra gave rise to projections into the basal forebrain. In the late 1950s, another clue emerged, this time linking observations from the field of neuropathology with a dis- covery in experimental neuropharmacology (Carlsson, 1959a,b; Ehringer and Hornykiewicz, 1960). It had long been recognized that patients with Par- kinson's disease suffered neuronal loss in the substantia nigra and that their symptoms were somehow related to striatal dysfunction. Thus, when flu- orescent catecholamine assays were developed and combined with pharma- cological and neuropathological studies of Parkinson's disease, the dopamin- ergic nature of the illness was shown. A bit later, Falck and Hillarp (Falck et at. , 1962) developed a fluorescent histochemical method to visualize mono- amine-containing cells in the brain; this technique was soon applied to show that the rich dopaminergic terminal field in the striatum derived from neu- rons in the substantia nigra (Anden et at. , 1964). In the following decade, refinements in the histofluorescent method and the development of sensitive silver impregnation methods permitted a detailed light microscopic explo- ration of the dopaminergic nigrostriatal system.

The knowledge of the mammalian central nervous pared by Ms. Anne Dunn. I am truly grateful for system has increased dramatically during the last their contributions. decade, which has provided a major impetus for A caveat is in order for the first 5 figures in preparing the second edition of The Human Brain Chapter 10, which represent cross-sections through and Spinal Cord. For the medical profession this has different levels of the brainstem. Considering the been a revolutionary time, since modem imaging rapidly expanding reliance on in vivo imaging by the methods have provided unparalleled opportunities clinicians, figures 10-1 to 10-5 are presented with for anatomical and functional studies of the human the posterior parts of the brainstem facing down body in vivo. It is now essential for the clinician to wards, since this is the way the brainstem images have an intimate knowledge of anatomy including appear in axial MRls routinely used by neuro the functional-anatomical systems in the brain radiologists (see Chapter 5). This somewhat un and spinal cord. The new edition of this textbook conventional approach, suggested by Dr. Duane reflects this progress in the sense that almost all of Haines, is directly relevant for the transfer of basic the chapters have been rewritten and several new science information to clinical practice. All other figures have been included.

Published by Sinauer Associates, an imprint of Oxford University Press. The need in medicine and basic science for a sophisticated knowledge of human brain anatomy is greater now than ever before. Clinically, the emergence of ever more sophisticated brain imaging modalities and continually increasing capacity to precisely target specific sites for deep brain stimulation and focal lesions demand that neuroanatomical knowledge of the human brain keeps pace. Tremendous progress during the last thirty years in revealing details of neural connections and principles of organization of animal brains demands that the basic neuroscientist discern what these principles mean to the organization of the human brain, which is still best appreciated by careful dissection. No textbook or model can replace dissection of the human brain as the ultimate educational experience. Lennart Heimer, MD, one of the most respected neuroanatomy educators of his time, has created a practical guide for the systematic dissection of the human brain. This DVD contains two separate dissection guides. One emphasizes the technique of blunt dissection for the study of major fiber bundles, and the second focuses on surface topography, coronal/horizontal sections, and exploration of the ventricle system. Includes complete narration text in Microsoft Word format.