The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The book begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Covered next are the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The following section examines the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. The book contains scores of color figures and fully updated chapters; online content packaged exclusively with the Fourth Edition includes detailed animations of neural processes, in-depth supplemental reading, and additional full-color figures and tables.

Membrane Biomechanics, Volume 86, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on Lipid bilayers: phase behavior and mechanics, Molecular mechanisms of cell membrane structure modification by omega-3 fatty acids, Mechanical properties of magnetoliposomes, Mechanosensitive ion channels and membrane tension, From cell membrane to the nuclear membrane through modulation of cytoskeleton, Endothelial stiffness in dyslipidemia and aging, Vascular smooth muscle stiffness in aging and vascular disease, Mechanobiology of macrovesicle release and activation, Interplay of membrane cholesterol and substrate on vascular smooth muscle mechanics, and more.

The establishment of relationships between sediment composition and climatic - vironment in the sediment basin and subsequent evolution of climate relates to the classical problems of fundamental sedimentology. The widely known publications by the Russian academicians N. M. Strakhov, A. B. Ronov, and A. P. Lisitsin are dedicated to different aspects of this problem. In particular, the monograph p- lished by A. P. Lisitsin "Sea-ice and iceberg sedimentation in the Ocean: recent and past" (Lisitsin, 2002) closely corresponds to the issues examined in this book. This monograph discusses in detail the environments and means of accumulations of recent marine and oceanic sediments in the ice zone of sedimentation of the Ocean, however, much less attention is given to the history of ice sedimentation, especially to high-resolution paleoceanography. In the present work the authors accepted the following basic principles: 1. StudynotonlyoftheArctic, butalsooftheSubarctic, especiallyofthoseregions, where there were conducted the original studies by the authors. 2. Study of climatic history in uence ( rst of all, - the glaciation evolution of NorthernHemisphere)on sedimentationforthe last 130ka (MIS5e - MIS1)not only in the marine periglacial environment (term of G. G. Matishov), but also in the deep water areas and on the adjacent continental blocks. 3. Imperative description of recent sedimentation environment for subsequent - plication of the comparative-lithologicalmethod. 4. Detailed consideration of accessible stratigraphic and geo-chronometricdata for partition and correlation of various sedimentary facies. Some of the above-mentionedprinciples require further explanation.

This study, written by seasoned professionals and academics in the field of information management and public policy, presents a clear exposition of what makes up infostructures, how they are created and used, and how they affect the policy-making process. The only study to address both information management and technology and the policy process itself, it offers a balanced treatment of the numerous resources and activities required to generate and feed information into public sector decision-making.

New Methods and Sensors for Membrane and Cell Volume Research, Volume 88 provides an overview of novel experimental approaches to study both the cell membrane and the under-membrane space - the cytosol, which have lately began drawing renewed attention. The book's overall emphasis is on fluorescent and FRET-based sensors, however, other optical (such as variants of transmission microscopy) and non-optical methods (neutron scattering and mass spectrometry) also have dedicated chapters. This volume provides a rare review of experimental approaches to study intracellular phase transitions, as well as anion channels, membrane tension and dynamics, and other topics of intense current interest.

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

'Et moi, ... si j'avait su comment en revenir, One service mathematics has rendered the je n'y serais point allC: .' human. race. It has put common sense back Jules Verne where it belongs, on the topmost shelf next to the dusty canister labelled 'discarded non- The series is divergent; therefore we may be sense'. able to do something with it. Eric T. Bell O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and non linearities abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sciences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One service topology has rendered mathematical physics .. .'; 'One service logic has rendered com puter science .. .'; 'One service category theory has rendered mathematics .. .'. All arguably true. And all statements obtainable this way form part of the raison d'ttre of this series."

The British census plays an unquestioned role in governance today, and the recent digitization of nineteenth century census data has allowed millions of amateur and professional researchers to visualize their national and familial past. This study tells the tangled story of how the census took shape over the early decades of its existence, developing from a simple counting of households during the Napoleonic Wars into a centralized undertaking that involved the governmental and intellectual luminaries of Victorian Britain. Along the way, the census intertwined with the pressing questions of the day, including Malthusianism, industrialization, political representation, Irish immigration, women's employment, reproduction, and empire. The book explores the hotly disputed process by which the census was created and developed and examines how a wide cast of characters, including statisticians, novelists, national and local officials, political and social reformers, and journalists responded to and used the idea of a census. It shows that the act of describing British society in statistical terms was also an act of contestation.

The interest in inverse problems of spectral analysis has increased considerably in recent years due to the applications to important non-linear equations in mathematical physics. This monograph is devoted to the detailed theory of inverse problems and methods of their solution for the Sturm-Liouville case. Chapters 1--6 contain proofs which are, in many cases, very different from those known earlier. Chapters 4--6 are devoted to inverse problems of quantum scattering theory with attention being focused on physical applications. Chapters 7--11 are based on the author's recent research on the theory of finite- and infinite-zone potentials. A chapter discussing the applications to the Korteweg--de Vries problem is also included. This monograph is important reading for all researchers in the field of mathematics and physics.

This book goes beyond the technical steps in the process of making film, TV, and media material, examining what it means to be an ongoing supplier of content to the marketplace and how to become one. Steve Levitan brings insights and experience from his lifelong career producing in the content industry, where he has also acted as a professional advisor to content makers, distributors and providers, whilst setting up his own production company. Producing as a Business offers strategic, tactical, financial, legal and marketing insights for the successful establishment of content creation enterprises. Readers will gain insight into how to avoid starting from square one with each project, while also learning how to maintain a meaningful level of ownership and build a revenue stream that can sustain a core operation, helping establish them as a “player” in the industry. This text is aimed at the international production industry, with real examples referred to throughout. Film, television, and media production students who are looking to understandthe business of producing, as well as first-time producers who are already familiar with the basics of the production process, will benefit from an examination of the building blocks that form lasting production companies.

This book goes beyond the technical steps in the process of making film, TV, and media material, examining what it means to be an ongoing supplier of content to the marketplace and how to become one. Steve Levitan brings insights and experience from his lifelong career producing in the content industry, where he has also acted as a professional advisor to content makers, distributors and providers, whilst setting up his own production company. Producing as a Business offers strategic, tactical, financial, legal and marketing insights for the successful establishment of content creation enterprises. Readers will gain insight into how to avoid starting from square one with each project, while also learning how to maintain a meaningful level of ownership and build a revenue stream that can sustain a core operation, helping establish them as a “player” in the industry. This text is aimed at the international production industry, with real examples referred to throughout. Film, television, and media production students who are looking to understandthe business of producing, as well as first-time producers who are already familiar with the basics of the production process, will benefit from an examination of the building blocks that form lasting production companies.

This book scrutinises how three small Scandinavian countries – Norway, Sweden and Denmark – developed a unique foreign policy that brought Israel and the Palestinians to the negotiating table. Bringing together the field of soft power diplomacy with the field of conflict mediation, the text analyses the specific type of peace diplomacy offered by Scandinavia. It identifies the different methods and policies of the three Scandinavian countries, as well as the strengths and weaknesses of their mediation strategies. Close examination of the historical record through primary and secondary sources in five languages reveals how Scandinavian involvement worked over almost three decades and to what extent it shaped the content of the Oslo peace talks. The author documents how the Scandinavian countries employed soft power diplomacy to enlist the aid of more powerful countries and international institutions to compensate for their limited authority and legitimacy, and how they used the Middle East peace process to strengthen their own national interests, financial standing and international status. The book will appeal to scholars, diplomats, politicians, educators and students interested in Scandinavian foreign policy and the Israeli-Palestinian conflict.

This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

In 1980, Ronald Reagan created one of the most stupid talking points of all time: "I'm not a scientist, but...". Since then, politicians have repeatedly committed egregious transgressions against scientific knowledge prefaced by this seemingly innocuous phrase. Yet, as science journalist Dave Levitan reveals, that line is just the tip of the melting iceberg when it comes to rhetorical tools wielded to attack scientific findings that don't cooperate with political agendas. Just listen to Mike Huckabee dismiss climate change as "a sunburn", Donald Trump suggest that vaccines cause autism or Todd Akin's infamous invention of "legitimate rape". With a taxonomer's eye, Levitan captures and categorises these deceptions by chapter, assigning delightful names like "The Butter-Up and Undercut", "The Literal Nitpick", "The Straight-Up Fabrication" and many more. His sharp humour dismantles America's leaders' deceptive arguments while illuminating the real science behind the worst soundbites from these elected non-scientists.

'Et moi, ... si j'avait su comment en revenir, One service mathematics has rendered the je n'y serais point allC: .' human. race. It has put common sense back Jules Verne where it belongs, on the topmost shelf next to the dusty canister labelled 'discarded non- The series is divergent; therefore we may be sense'. able to do something with it. Eric T. Bell O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and non linearities abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sciences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One service topology has rendered mathematical physics .. .'; 'One service logic has rendered com puter science .. .'; 'One service category theory has rendered mathematics .. .'. All arguably true. And all statements obtainable this way form part of the raison d'ttre of this series."

The establishment of relationships between sediment composition and climatic - vironment in the sediment basin and subsequent evolution of climate relates to the classical problems of fundamental sedimentology. The widely known publications by the Russian academicians N. M. Strakhov, A. B. Ronov, and A. P. Lisitsin are dedicated to different aspects of this problem. In particular, the monograph p- lished by A. P. Lisitsin "Sea-ice and iceberg sedimentation in the Ocean: recent and past" (Lisitsin, 2002) closely corresponds to the issues examined in this book. This monograph discusses in detail the environments and means of accumulations of recent marine and oceanic sediments in the ice zone of sedimentation of the Ocean, however, much less attention is given to the history of ice sedimentation, especially to high-resolution paleoceanography. In the present work the authors accepted the following basic principles: 1. StudynotonlyoftheArctic, butalsooftheSubarctic, especiallyofthoseregions, where there were conducted the original studies by the authors. 2. Study of climatic history in uence ( rst of all, - the glaciation evolution of NorthernHemisphere)on sedimentationforthe last 130ka (MIS5e - MIS1)not only in the marine periglacial environment (term of G. G. Matishov), but also in the deep water areas and on the adjacent continental blocks. 3. Imperative description of recent sedimentation environment for subsequent - plication of the comparative-lithologicalmethod. 4. Detailed consideration of accessible stratigraphic and geo-chronometricdata for partition and correlation of various sedimentary facies. Some of the above-mentionedprinciples require further explanation.

Tales of Dionysus is the first English verse translation of one of the most extraordinary poems of the Greek literary tradition, the Dionysiaca of Nonnus of Panopolis. By any standard, the Dionysiaca is a formidable work. It is by far the longest poem surviving from the classical world, a massive mythological epic stretching to over 20,000 lines, written in the tradition of Homer, using Homer's verse, Homer's language, his narrative turns and motifs, and invoking his ancient Muses. But it is also the last ancient epic to follow a Homeric model, composed so late in fact that it stands as close in time to the Renaissance as it does to archaic Greece. Like its titular hero, Dionysus, with his fluidity of forms, names, and divine incarnations, the poem itself is continually shifting shape. Out of its formal epic frame spills a tumult of ancient literary types: tragedy, elegy, didactic, panegyric, pastoral idyll, and the novel are all parts of this gigantic enterprise, each genre coming to the fore one after the other.Tales of Dionysus brings together forty-two translators from a wide range of backgrounds, with different experiences and different potential relationships to the text of Nonnus' poem. All work in their own styles and with their own individual approaches to the poem, to translation, and to poetic form. This variety turns Tales of Dionysus into a showcase of the multiple possibilities open to classical translation in the contemporary world.

This powerful resource is for researchers and educational leaders who are interested in understanding and applying research methods that emphasize youth voice. The authors argue that most educational research either omits critical understandings of youth or, even worse, presents inaccuracies due to faulty techniques. Researching how youth experience their schools and communities requires specific conceptual tools that address researcher bias, power dynamics, and the contextual considerations that impact meaning-making processes. Responding to these issues, the authors present the Student Voice Research Framework-an approach that both novice and advanced researchers can use to address assumptions and overcome bias as they engage with youth. Readers are provided with clear steps for implementing the framework, as well as examples of how some of the most innovative qualitative and quantitative researchers in the world are using it. The text includes numerous interview, survey, and other protocols with strategies that researchers can use immediately or adapt for their own studies. This comprehensive volume is a must-have for anyone doing research about and with youth. Book Features: Guidance for addressing persistent problems of bias in educational inquiry to better engage in study about and with students. Examination of student voice research as its own field with its own typologies and research questions. Chapters highlighting innovative qualitative and quantitative research methods and strategies with ready-to-use protocols and other tools. A forward-looking conversation about social justice and what democracy could look like in schools. A toolkit of research methods and school change processes to address difficult questions in education.

Tales of Dionysus is the first English verse translation of one of the most extraordinary poems of the Greek literary tradition, the Dionysiaca of Nonnus of Panopolis. By any standard, the Dionysiaca is a formidable work. It is by far the longest poem surviving from the classical world, a massive mythological epic stretching to over 20,000 lines, written in the tradition of Homer, using Homer's verse, Homer's language, his narrative turns and motifs, and invoking his ancient Muses. But it is also the last ancient epic to follow a Homeric model, composed so late in fact that it stands as close in time to the Renaissance as it does to archaic Greece. Like its titular hero, Dionysus, with his fluidity of forms, names, and divine incarnations, the poem itself is continually shifting shape. Out of its formal epic frame spills a tumult of ancient literary types: tragedy, elegy, didactic, panegyric, pastoral idyll, and the novel are all parts of this gigantic enterprise, each genre coming to the fore one after the other. Tales of Dionysus brings together forty-two translators from a wide range of backgrounds, with different experiences and different potential relationships to the text of Nonnus' poem. All work in their own styles and with their own individual approaches to the poem, to translation, and to poetic form. This variety turns Tales of Dionysus into a showcase of the multiple possibilities open to classical translation in the contemporary world.