This book focuses on profiling, analysing, benchmarking and modelling in socio-economic terms, the ways that creativity, invention and innovation flourish. The work is based on comparative, conceptual and empirical research of 15 American, European and Asian knowledge-based innovation networks and knowledge clusters. It highlights critical success and failure factors, and the lessons learned about entrepreneurial initiatives, outcomes and impacts. It identifies and articulates insights that inform both public sector policies and private sector practices to render them more effective and efficient.