"Unhistorical Shakespeare" argues that the way in which we study history has significant bearing on what desire we study, and how we study it. Menon argues that our embrace of difference as the template for relating past and present produces a hetero temporality in which chronology determines identity. In turn, such an understanding of history fixes sexual identity as the domain of the present and relegates nebulous desire to a thing of the past. In contrast to this temporal-sexual reification, "Unhistorical Shakespeare" outlines the idea of homohistory, which questions the fundamental historicist assumptions of teleology, facticity, citation, origins, and authenticity to lay bare their investments in compulsory hetero temporality.

This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments - particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter.The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the first of the 3-volume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials - Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power - A Non-proportional Hazards Perspective.

This book imagines the ocean as central to understanding the world and its connections in history, literature and the social sciences. Introducing the central conceptual category of ocean as method, it analyzes the histories of movement and traversing across connected spaces of water and land sedimented in literary texts, folklore, local histories, autobiographies, music and performance. It explores the constant flow of people, material and ideologies across the waters and how they make their presence felt in a cosmopolitan thinking of the connections of the world. Going beyond violent histories of slavery and indenture that generate global connections, it tracks the movements of sailors, boatmen, religious teachers, merchants, and adventurers. The essays in this volume summon up this miscegenated history in which land and water are ever linked. A significant rethinking of world history, this volume will be of great interest to scholars and researchers of history, especially connected history and maritime history, literature, and Global South studies.

This book is an original, systematic, and radical attempt at decolonizing critical theory. Drawing on linguistic concepts from 16 languages from Asia, Africa, the Arab world, and South America, the essays in the volume explore the entailments of words while discussing their conceptual implications for the humanities and the social sciences everywhere. The essays engage in the work of thinking through words to generate a conceptual vocabulary that will allow for a global conversation on social theory which will be necessarily multilingual. With essays by scholars, across generations, and from a variety of disciplines - history, anthropology, and philosophy to literature and political theory - this book will be essential reading for scholars, researchers, and students of critical theory and the social sciences.

Ocean as Method presents a new way of thinking about the humanities and the social sciences. It explores maritime connections in social and humanistic research and puts forward an alternative to national histories and area studies. As global warming and rising sea levels ring alarm bells across the world, the chapters in the volume argue that it is time to think through oceans to realign discourses which better understand our future. The volume: * Engages with the paradigms of oceanic narratives to identify connections between continents through trade, migration, and economic processes, thinking beyond the artificial distinctions between the Pacific, Atlantic, and Indian Oceans; * Discusses oceanic travel accounts by Muslim travellers to counter the idea that the colonial era was marked by European travel to Asia and Africa, without a counterflow of "native travel"; *Examines the connections between South Africa, South Asia, and South East Asia through histories of Indian indenture and the slave trade, and engages with the idea of the ocean and enforced movement; *Compares and connects recent scholarship in the social sciences and the humanities centring the ocean to break away from inherited paradigms which have shaped world history so far. As a unique transdisciplinary collaboration, this volume will be of much interest to scholars and researchers of history, especially oceanic history, historiography, critical theory, literature, geography, and Global South studies.

Ocean as Method presents a new way of thinking about the humanities and the social sciences. It explores maritime connections in social and humanistic research and puts forward an alternative to national histories and area studies. As global warming and rising sea levels ring alarm bells across the world, the chapters in the volume argue that it is time to think through oceans to realign discourses which better understand our future. The volume: * Engages with the paradigms of oceanic narratives to identify connections between continents through trade, migration, and economic processes, thinking beyond the artificial distinctions between the Pacific, Atlantic, and Indian Oceans; * Discusses oceanic travel accounts by Muslim travellers to counter the idea that the colonial era was marked by European travel to Asia and Africa, without a counterflow of "native travel"; *Examines the connections between South Africa, South Asia, and South East Asia through histories of Indian indenture and the slave trade, and engages with the idea of the ocean and enforced movement; *Compares and connects recent scholarship in the social sciences and the humanities centring the ocean to break away from inherited paradigms which have shaped world history so far. As a unique transdisciplinary collaboration, this volume will be of much interest to scholars and researchers of history, especially oceanic history, historiography, critical theory, literature, geography, and Global South studies.

Confidence Intervals for Discrete Data in Clinical Research is designed as a toolbox for biomedical researchers. Analysis of discrete data is one of the most used yet vexing areas in clinical research. The array of methodologies available in the literature to address the inferential questions for binomial and multinomial data can be a double-edged sword. On the one hand, these methods open a rich avenue of exploration of data; on the other, the wide-ranging and competing methodologies potentially lead to conflicting inferences, adding to researchers' confusion and frustration and also leading to reporting bias. This book addresses the problems that many practitioners experience in choosing and implementing fit for purpose data analysis methods to answer critical inferential questions for binomial and count data. The book is an outgrowth of the authors' collective experience in biomedical research and provides an excellent overview of inferential questions of interest for binomial proportions and rates based on count data, and reviews various solutions to these problems available in the literature. Each chapter discusses the strengths and weaknesses of the methods and suggests practical recommendations. The book's primary focus is on applications in clinical research, and the goal is to provide direct benefit to the users involved in the biomedical field.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

This book imagines the ocean as central to understanding the world and its connections in history, literature and the social sciences. Introducing the central conceptual category of ocean as method, it analyzes the histories of movement and traversing across connected spaces of water and land sedimented in literary texts, folklore, local histories, autobiographies, music and performance. It explores the constant flow of people, material and ideologies across the waters and how they make their presence felt in a cosmopolitan thinking of the connections of the world. Going beyond violent histories of slavery and indenture that generate global connections, it tracks the movements of sailors, boatmen, religious teachers, merchants, and adventurers. The essays in this volume summon up this miscegenated history in which land and water are ever linked. A significant rethinking of world history, this volume will be of great interest to scholars and researchers of history, especially connected history and maritime history, literature, and Global South studies.

Expand the scope of your social work practice or education program Computers and Information Technology in Social Work: Education, Training, and Practice discusses the impact that recent technological advances have had on social work practice and education. This unique book covers a wide range of topics for social workers and educators highlighting various aspects of technology applied to assist those in helping professions. You'll learn how computers can be used in child protective cases and the benefits of videoconferencing in social work programs. Computers and Information Technology in Social Work will show you how new advances in technology can improve your social work practice or education program.Computers and Information Technology in Social Work examines many different aspects of technology and demonstrates how they can be applied to assist you in making a positive impact on the communities, clients, and organizations that you serve. This guide offers specific methods and suggestions for providing students with better services and enhanced instruction on the use of current technologies in social work practice.Computers and Information Technology in Social Work is packed with innovative concepts that will improve your effectiveness through the use of advanced technology. You will: discover the impact that video conferencing technology can have on the delivery of social services to rural populations and undeveloped areas of the world gain insight into the lives of isolated and vulnerable people, such as those in a breast cancer support group, who can directly benefit from technological advances like video conferencing learn how television can be used by social work practitioners to positively impact communities by providing programs that teach self-advocacy and provide outreach and peer support examine World Wide Web-based instructional resources to help students access information on their own time, at their own pace, and from any computer location discover a World Wide Web-based conferencing program that allows professors expanded opportunities for teaching, learning, and communicationDerived from papers that were presented at a week-long conference sponsored by the University of South Carolina College of Social Work, Computers and Information Technology in Social Work presents exciting and innovative ideas and projects to keep you abreast of technical developments in the field and how they can best assist your practice. The unique ideas presented in this book will enable you to provide more effective services to your clients with the help of information technology.

Expand the scope of your social work practice or education program Computers and Information Technology in Social Work: Education, Training, and Practice discusses the impact that recent technological advances have had on social work practice and education. This unique book covers a wide range of topics for social workers and educators highlighting various aspects of technology applied to assist those in helping professions. You'll learn how computers can be used in child protective cases and the benefits of videoconferencing in social work programs. Computers and Information Technology in Social Work will show you how new advances in technology can improve your social work practice or education program. Computers and Information Technology in Social Work examines many different aspects of technology and demonstrates how they can be applied to assist you in making a positive impact on the communities, clients, and organizations that you serve. This guide offers specific methods and suggestions for providing students with better services and enhanced instruction on the use of current technologies in social work practice.Computers and Information Technology in Social Work is packed with innovative concepts that will improve your effectiveness through the use of advanced technology.You will: discover the impact that video conferencing technology can have on the delivery of social services to rural populations and undeveloped areas of the world gain insight into the lives of isolated and vulnerable people, such as those in a breast cancer support group, who can directly benefit from technological advances like video conferencing learn how television can be used by social work practitioners to positively impact communities by providing programs that teach self-advocacy and provide outreach and peer support examine World Wide Web-based instructional resources to help students access information on their own time, at their own pace, and from any computer location discover a World Wide Web-based conferencing program that allows professors expanded opportunities for teaching, learning, and communication Derived from papers that were presented at a week-long conference sponsored by the University of South Carolina College of Social Work, Computers and Information Technology in Social Work presents exciting and innovative ideas and projects to keep you abreast of technical developments in the field and how they can best assist your practice.The unique ideas presented in this book will enable you to provide more effective services to your clients with the help of information technology.

This book is an original, systematic, and radical attempt at decolonizing critical theory. Drawing on linguistic concepts from 16 languages from Asia, Africa, the Arab world, and South America, the essays in the volume explore the entailments of words while discussing their conceptual implications for the humanities and the social sciences everywhere. The essays engage in the work of thinking through words to generate a conceptual vocabulary that will allow for a global conversation on social theory which will be necessarily multilingual. With essays by scholars, across generations, and from a variety of disciplines - history, anthropology, and philosophy to literature and political theory - this book will be essential reading for scholars, researchers, and students of critical theory and the social sciences.

In 1957, Kerala became the first region in Asia to elect a communist government parliamentary procedure. Dilip Menon's book traces the social history of comunism in Malabar, the bastion of the movement, and looks at how the ideology was transformed into a doctrine of caste equality, as national strategies were reshaped by local circumstance and tinged by pragmatism. While existing literature concentrates on the intricacies of party policy, Dilip Menon explores the diversity of political practice within a particular region. He particularly analyses the relationship between landowners and cultivators, demonstrating their economic and cultural interdependence. Inequality and difference were tempered by a perception of shared symbols and values. As the author points out, the success of communism in Kerala lies in its recognition of this fact.

The Future of Clinical Research and Health Care: From Empirical to Precision MedicineClinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease TreatmentThe first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side EffectsDespite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

This book tries to decenter work on the history of capitalism by looking at the longue duree from the tenth century; at regions as diverse as Song China, South and South East Asia, Latin America and the Ottoman and Safavid Empires; and exploring the plurality of developments over this extended time and space. The authors argue against conventional accounts that locate the origins of capitalism solely within Europe and within the conjuncture of the industrial revolution. The essays emphasize historical conjunctures, flows of commodities, circulation of knowledge and personnel, the role of mercantile capital and small producers and stress throughout the necessity to think beyond present day national boundaries. The volume contends with cliches of Western exceptionalism to make a set of historical arguments about non-Western and interconnected economic developments across the globe, prior to the era of colonialism. It argues fundamentally that the multiple histories of capitalism can be better understood from a truly global perspective.

Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various potential drug development strategies, the design and analysis of pharmacokinetics (PK) studies, and the design and analysis of efficacy studies.

The Future of Clinical Research and Health Care: From Empirical to Precision Medicine Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers.Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.