Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

The principle of content-neutrality is the cornerstone of freedom of expression jurisprudence, protecting the core values of freedom of speech set out in the first amendment, whilst also enabling the government to place reasonable restrictions on protected speech. The Politics of Freedom of Expression examines the US Supreme Court's decision-making in freedom of expression cases, from the Earl Warren Court in 1953 to the 2012 decisions of the John Roberts Court, assessing the extent to which the justices take into consideration their own political attitudes, jurisprudence and external factors such as federal government participation. In doing so, the book highlights the role of the civil rights movement in developing the content-neutrality jurisprudential regime. Establishing 'jurisprudential regime theory' as a framework for incorporating the various factors that can affect decision-making, the author draws on quantitative, qualitative and interpretive methods in order to analyse the justices' changing treatment of content-based and content-neutral cases over time. This unique theoretical approach allows the text to push beyond the traditional 'law versus politics' debate in order to critically evaluate the importance of content-neutrality to the Supreme Court's decision-making, and to compare decision-making in the US with Canada, Germany, Japan and the UK.

Praise for the Series:
"The authority, originality, and editing of the review are first class."
--Nature
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
--Journal of the American Chemical Society

Key Features
* Respiratory metabolism in hyperthermophilic organisms
* Structure and stability of hyperstable proteins
* Thermostable DNA polymerases
* DNA stability and DNA binding proteins
* Hyperthermophiles and their heat-shock proteins

From the Reviews of the Previous Volumes
"The authority, originality, and editing of the reviews are first class."
-NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elizabeth I was Queen of England for almost forty-five years. The daughter of Henry VIII and Ann Boleyn, as an infant she was briefly accepted as her father's heir. After her mother was executed at her father's command she was declared illegitimate and led a sometimes scandalous existence until her accession to the throne at the age of twenty-five. Elizabeth oversaw a vibrant age of exploration and literature and established herself, the "Virgin Queen", a national icon that lives on in the popular imagination. But Elizabeth was England's second female monarch, and was greatly influenced by the experiences and mistakes of the reign of her half-sister, Mary I, before her. During her reign, Elizabeth had to perform a complicated balancing act in religious matters. As religious wars raged in Europe, Elizabeth herself a moderate Protestant, had to manage an inherited Catholic realm and the demands of zealous Protestants. The importance of such familiar features of Elizabeth's reign as the presence in England of Mary Queen of Scots and her enduring efforts to take the throne, the Spanish armada, and the origins of English colonial expansion beyond the British archipelago all receive fresh attention in this engaging book. This new biography sheds light on Elizabeth's early life, influences and on her personal religious beliefs as well as examining her reign, politics and reassesses Elizabeth's reluctance to marry, a matter for which she has been much praised, but which is here judged one of the second queen regnant's more problematic decisions. Judith M. Richards takes an objective and rounded view of Elizabeth's whole life and provides the perfect introduction for students and general readers alike.

This book highlights the multiple ways of telling stories of radiation exposure; they include stories about Japan, Australia, the United States, the Canadian Arctic, and more, and they probe the framing of major incidents such as Three Mile Island, Chernobyl, and Fukushima. All the chapters in this book are written by authors who participated in our work at Oregon State University and have benefited from hearing not only from scientists but also from those whose lives were directly affected by the history of radiation exposure. The question 'What is at stake when researching and narrating the histories of radiation exposure?' is discussed, but the book does not reinforce existing frameworks, such as legal decisions or government policies, but rather highlights what narrative framings accomplish and commit by scrutinizing them with rigorous research, varied approaches, and, above all, listening to those whose lives were most affected by exposure. Previously published in Journal of the History of Biology Volume 54, issue 1, April 2021

Mary Tudor is often written off as a hopeless, twisted queen who tried desperately to pull England back to the Catholic Church that was so dear to her mother, and sent many to burn at the stake in the process. In this radical re-evaluation of the first 'real' English queen regnant, Judith M. Richards challenges her reputation as 'Bloody Mary' of popular historical infamy, contending that she was closer to the more innovative, humanist side of the Catholic Church. Richards argues persuasively that Mary, neither boring nor basically bloody, was a much more hard-working, 'hands on', and decisive queen than is commonly recognized. Had she not died in her early forties and failed to establish a Catholic succession, the course of history could have been very different, England might have remained Catholic and Mary herself may even have been treated more kindly by history. This illustrated and accessible biography is essential reading for all those with an interest in one of England's most misrepresented monarchs.

Elizabeth I was Queen of England for almost forty-five years. The daughter of Henry VIII and Ann Boleyn, as an infant she was briefly accepted as her father s heir. After her mother was executed at her father s command she was declared illegitimate and led a sometimes scandalous existence until her accession to the throne at the age of twenty-five. Elizabeth oversaw a vibrant age of exploration and literature and established herself, the "Virgin Queen," a national icon that lives on in the popular imagination. But Elizabeth was England s second female monarch, and was greatly influenced by the experiences and mistakes of the reign of her half-sister, Mary I, before her. During her reign, Elizabeth had to perform a complicated balancing act in religious matters. As religious wars raged in Europe, Elizabeth herself a moderate Protestant, had to manage an inherited Catholic realm and the demands of zealous Protestants. The importance of such familiar features of Elizabeth s reign as the presence in England of Mary Queen of Scots and her enduring efforts to take the throne, the Spanish armada, and the origins of English colonial expansion beyond the British archipelago all receive fresh attention in this engaging book. This new biography sheds light on Elizabeth s early life, influences and on her personal religious beliefs as well as examining her reign, politics and reassesses Elizabeth s reluctance to marry, a matter for which she has been much praised, but which is here judged one of the second queen regnant s more problematic decisions. Judith M. Richards takes an objective and rounded view of Elizabeth s whole life and provides the perfect introduction for students and general readers alike.

Originally published in 1979 with a second edition in 1985. A basic text for students of education and teachers who are coming to terms for the first time with the nature of the curriculum. It introduces the reader to the professional field that is of concern to all engaged in the practical enterprise of education in a way which provides a 'feel' for the preoccupations of the area and a 'sense' of its complexities. With annotated further reading included, the book reflects developments in all the major areas in curriculum design and evaluation and in effecting curriculum change, plus research and theory.

Black Heart is a provocative and polemical critique of African American literary studies at the beginning of the twenty-first century. Through a series of sharp and insightful essays on a wide range of critical thinkers, Phillip M. Richards traces what he sees as an erosion of moral reflection in African American literary culture - a process that has left contemporary black academic criticism socially, politically, and culturally hollow. Exploring the work of Henry Louis Gates, Jr., Michael Dyson, Karla Holloway and others, Black Heart sets forth the rhetorical strategies of present day African American critical writing, and probes the ethical dimensions of its institutional life in the academy, the media, and the public sphere. Richards under takes to recover the procedures by which cultural and moral value may be recovered for black literary culture and to establish the possibilities for a new humanism in African American writing and literary culture.

Coastal ecosystems make up some of the most important, yet most endangered, regions in the world. The protection of the unique processes that take place in these ecosystems requires that partnerships be formed among ecologists, resource managers, and planners.

Experienced in the challenges of coastal system analysis, the contributors to this book provide multidisciplinary guidance on the assessment and management of environmental impacts caused by development. Each chapter examines an issue important to these fragile ecosystems, first presenting a non-technical summary of the issue and a review of the current state of the knowledge, then following with data and a more detailed consideration of the topic. Functioning both as a practical guide, accessible to nonscientists, and as a rigorous scientific source book, Changing Land Use Patterns in the Coastal Zone will be useful to ecologists, urban and regional planners, resource managers, policymakers and students. While many of the case studies included in this volume are drawn from studies in the southeastern United States, the examples and lessons provided will be relevant to those working in all coastal environments.

About the Editors:

G. S. Kleppel is Professor and Director of the Biodiversity, Conservation and Policy Program at the State University of New York at Albany. M. Richard DeVoe is Executive Director of the South Carolina Sea Grant Consortium in Charleston, South Carolina. Mac V. Rawson, Jr. is Director of the Georgia Sea Grant Program at the University of Georgia, Athens.

Originally published in 1979 with a second edition in 1985. A basic text for students of education and teachers who are coming to terms for the first time with the nature of the curriculum. It introduces the reader to the professional field that is of concern to all engaged in the practical enterprise of education in a way which provides a 'feel' for the preoccupations of the area and a 'sense' of its complexities. With annotated further reading included, the book reflects developments in all the major areas in curriculum design and evaluation and in effecting curriculum change, plus research and theory.

From "Brown v. Board of Education" to "Roe v. Wade" to "Bush v. Gore," the Supreme Court has, over the past fifty years, assumed an increasingly controversial place in American national political life. As the recurring struggles over nominations to the Court illustrate, few questions today divide our political community more profoundly than those concerning the Court's proper role as protector of liberties and guardian of the Constitution. If the nation is today in the midst of a "culture war," the contest over the Supreme Court is certainly one of its principal battlefields.In this volume, distinguished constitutional scholars aim to move debate beyond the sound bites that divide the opposing parties to more fundamental discussions about the nature of constitutionalism. Toward this end, the volume includes chapters on the philosophical and historical origins of the idea of constitutionalism; on theories of constitutionalism in American history in particular; on the practices of constitutionalism around the globe; and on the parallel emergence of--and the persistent tensions between--constitutionalism and democracy throughout the modern world.In democracies, the primary point of having a constitution is to place some matters beyond politics and partisan contest. And yet it seems equally clear that constitutionalism of this kind results in a struggle over the meaning or proper interpretation of the constitution, a struggle that is itself deeply political. Although the volume represents a variety of viewpoints and approaches, this struggle, which is the central paradox of constitutionalism, is the ultimate theme of all the essays.

How to Succeed With Online Learning, is focused on 1) learning how to learn in this new environment, 2) how to assure successful course completion, and 3) how to attain excellent academic performance. This book will guide you from the registration process through course completion in a plain English, straight-forward, and efficient way. Each chapter provides actual segments of an online course. Illustrations are used to highlight each topic discussed. The authors have extensive experience in online teaching/learning and have researched the best practices to achieve success. Opportunities exist for furthering one's education and earning a degree entirely online. Online learning is not dissimilar to any other form of learning. The only difference is the delivery mode. Your visible presence in the Cyber Classroom is your intellect, your wit, your personality and your writing skills. You can do it

This comprehensive treatise on the reticuloendothelial system is a project jointly shared by individual members of the Reticuloendothelial (RE) Society and bio medical scientists in general who are interested in the intricate system of cells and molecular moieties derived from those cells which constitute the RES. It may now be more fashionable in some quarters to consider these cells as part of what is called the mononuclear phagocytic system or the lymphoreticular system. Nevertheless, because of historical developments and current interest in the subject by investigators from many diverse areas, it seems advantageous to present in one comprehensive treatise current information and knowledge con cerning basic aspects of the RES, such as morphology, biochemistry, phylogeny and ontogeny, physiology, and pharmacology as weIl as clinical areas including immunopathology, cancer, infectious diseases, allergy, and hypersensitivity. It is anticipated that by presenting information concerning these apparently heterogeneous topics under the unifying umbrella of the RES attention will be focused on the similarities as weIl as interactions among the cell types constitut ing the RES from the viewpoint of various disciplines. The treatise editors and their editorial board, consisting predominantly of the editors of individual vol umes, are extremely grateful for the enthusiastic cooperation and enormous task undertaken by members of the biomedical community in general and especially by members of the American as weIl as European and Japanese Reticuloendothe lial Societies."

An extraordinary development of the knowledge, concepts and biomedical applications has occurred during the past two decades in the biological sciences, including the Reticuloendothelial Sys- tem (RES). For example, it is now widely recognized that distinct classes of cells are involved in the recognition of "exogenous" invaders of the body such as microorganisms and other foreign an- tigens, as well as of "endogenous" parasites represented by trans- formed neoplastic cells and altered "self" antigens. Prominent among cell populations involved in such recognition of antigens and subsequent immune responses are those constituting the RES. In recent years, there has been much discussion and indeed contro- versy as to what constitutes such a system and even whether the term "RES" is appropriate. Some investigators feel that the phago- cytes are the most important cells of the RES as they playa major role in the defense mechanism of the host. Mononuclear phagocytes include tissue macrophages ~s well as circulating monocytes and their precursors. Although phagocytosis is a major functional ac- tivity, it is only one of their several functions. The important role of phagocytes and other mononuclear cells in antibody forma- tion, cell-mediated immunity, specific and non-specific resistance to microorganisms and tumor cells, as well as homeostatic adjust- ments in general has become the focus of attention for many inves- tigators.

This book contains the proceedings of a symposium held at the College of Charleston, Charleston, South Carolina, USA, 16-20 June 1986. The seed for this symposium arose from a group of physiologists , soU scientists and biochemists that met in Leningrad, USSR in July 1975 at the 12th Botanical Conference in a Session organized by Professor B.B. Vartepetian. This group and others later conspired to contribute to a book entitled Plant Life in Anaerobic Environments (eds. D. D. Hook and R. M. M. Crawford, Ann Arbor Science, 1978). Several contributors to the book suggested in 1983 that a broad-scoped symposium on wetlands would be useful (a) in facilitating communication among the diverse research groups involved in wetlands research (b) in bringing researchers and managers together and (c) in presenting a com prehensive and balanced coverage on the status of ecology ami management of wetlands from a global perspective. With this encouragement, the senior editor organized a Plan ning Committee that encompassed expertise from many disciplines of wetland scientists and managers. This Committee, with input from their colleagues around the world, organized a symposium that addressed almost every aspect of wetland ecology and management.

Coastal ecosystems make up some of the most important and, yet, most endangered, regions in the world. The protection of the unique processes that take place in these ecosystems requires that partnerships be formed among ecologists, resource managers and planners.

Experienced in the challenges of coastal system analysis, the contributors to this book provide multidisciplinary guidance on the assessment and management of environmental impacts caused by development. Each chapter examines an issue important to these fragile ecosystems, first presenting a non-technical summary of the issue and a review of the current state of the knowledge, then following with data and a more detailed consideration of the topic. Functioning both as a practical guide, accessible to nonscientists, and as a rigorous scientific source book, Changing Land Use Patterns in the Coastal Zone will be useful to ecologists, urban and regional planners, resource managers, policymakers and students. While many of the case studies included in this volume are drawn from studies in the southeastern United States, the examples and lessons provided will be relevant to those working in all coastal environments.

Nunavut is a land of islands, encompassing some of the most remote places on Earth. It is also home to some of the world's most fascinating bird species. Birds of Nunavut is the first complete survey of every species known to occur in the territory. Co-written by a team of eighteen experts, it documents 295 species of birds (of which 145 are known to breed there), presenting a wealth of information on identification, distribution, ecology, behaviour, and conservation. Lavishly illustrated with over 800 colour photographs and 155 maps, this is a visually stunning reference work on the birds that live in and visit Nunavut.