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Immunogenicity of Biopharmaceuticals (Hardcover, 2008 ed.): Marco Weert, Eva Horn Moller Immunogenicity of Biopharmaceuticals (Hardcover, 2008 ed.)
Marco Weert, Eva Horn Moller
R4,415 Discovery Miles 44 150 Ships in 10 - 15 working days

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho's blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies. This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

Immunogenicity of Biopharmaceuticals (Paperback, Softcover reprint of hardcover 1st ed. 2008): Marco Weert, Eva Horn Moller Immunogenicity of Biopharmaceuticals (Paperback, Softcover reprint of hardcover 1st ed. 2008)
Marco Weert, Eva Horn Moller
R4,375 Discovery Miles 43 750 Ships in 10 - 15 working days

Immunogenicity of Biopharmaceuticals is the first book to comprehensively address the potential of an immune response to biopharmaceuticals. It is intended to give a broad overview of the current state-of-the-art regarding this subject. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

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