Immunogenicity of Biopharmaceuticals (Hardcover, 2008 ed.)

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho's blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies. This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Biotechnology: Pharmaceutical Aspects, VIII
Release date:	March 2008
First published:	2008
Editors:	Marco Weert • Eva Horn Moller
Dimensions:	254 x 178 x 17mm (L x W x T)
Format:	Hardcover
Pages:	266
Edition:	2008 ed.
ISBN-13:	978-0-387-75840-4
Categories:	Books > Professional & Technical > Biochemical engineering > Biotechnology > General Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	0-387-75840-2
Barcode:	9780387758404

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