In this issue of Critical Care Nursing Clinics, Guest Editor May M. Riley brings her considerable expertise to the topic of Infection Challenges in the Critical Care Unit. Top experts in the field cover key topics such as Implementing an Antimicrobial Stewardship Program, Pulmonary Infections, Including Ventilator-Associated Pneumonia (VAP), Preventing Central Line-Associated Bloodstream Infection (CLABSI), and more. Provides in-depth, clinical reviews on Infection Challenges in the Critical Care Unit, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 8 relevant, practice-oriented topics including Epidemiology of Invasive Fungal Disease; Management of Sepsis; Multidrug-Resistant Candida Species and Candidiasis Infections; Infections in Geriatric Patients; Transmission and Multidrug-Resistant Organisms; and more.