This book presents a detailed overview of the design, formatting, application, and development of microfluidic chips in the context of cell biology research, enumerating each element involved in microfluidics-based cell analysis, discussing its history, status quo, and future prospects, It also offers an extensive review of the research completed in the past decade, including numerous color figures. The individual chapters are based on the respective authors' studies and experiences, providing tips from the frontline to help researchers overcome bottlenecks in their own work. It highlights a number of cutting-edge techniques, such as 3D cell culture, microfluidic droplet technique, and microfluidic chip-mass spectrometry interfaces, offering a first-hand impression of the latest trends in the field and suggesting new research directions. Serving as both an elementary introduction and advanced guidebook, the book interests and inspires scholars and students who are currently studying microfluidics-based cell analysis methods as well as those who wish to do so.

This proceedings book helps bring insights from this array of technical sub-topics together, as advanced robot algorithms draw on the combined expertise of many fields-including control theory, computational geometry and topology, geometrical and physical modeling, reasoning under uncertainty, probabilistic algorithms, game theory, and theoretical computer science. Intelligent robots and autonomous systems depend on algorithms that efficiently realize functionalities ranging from perception to decision making, from motion planning to control. The works collected in this SPAR book represent the state of the art in algorithmic robotics. They originate from papers accepted to the 14th International Workshop on the Algorithmic Foundations of Robotics (WAFR), traditionally a biannual, single-track meeting of leading researchers in the field of robotics. WAFR has always served as a premiere venue for the publication of some of robotics' most important, fundamental, and lasting algorithmic contributions, ensuring the rapid circulation of new ideas. Though an in-person meeting was planned for June 15-17, 2020, in Oulu, Finland, the event ended up being canceled owing to the infeasibility of international travel during the global COVID-19 crisis.

Freud was addicted to cocaine and nicotine, Jung was psychotic for several years, and Margaret Mead remained closeted throughout her lifetime. Yet, adversities notwithstanding, they all made monumental contributions that still shape our view on ourselves and the world. This book includes biographies of fifteen modern explorers of the mind who altered the course of history. All of them were wounded healers who made great discoveries while struggling with traumatic life crises and emotional problems in their personal lives. Full of unexpected twists and turns, their life stories alone are worthy of our attention. In linking their maladies with their creativity, showing the vulnerable and human side of these giants, this book makes the greats approachable and illuminates their scientific findings through narrating their life stories.

This book offers a complete and well-organized review of the latest advances made in developing ultra-weak chemiluminescence techniques for analytical applications. It systematically introduces the current theories, mechanisms, instruments, technologies, and real applications of ultra-weak chemiluminescence. Compared to books devoted to the normal chemiluminescence and bioluminescence, this book covers a wide range of ultra-weak chemiluminescence based on inorganic chemical reactions and nanotechnology from a principle and practical point of view. This book is intended for readers who are interested in expanding their knowledge of chemiluminescence and employing ultra-weak chemiluminescence techniques to develop new detection methods for analytical applications.

This book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor's laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.

This proceedings book helps bring insights from this array of technical sub-topics together, as advanced robot algorithms draw on the combined expertise of many fields-including control theory, computational geometry and topology, geometrical and physical modeling, reasoning under uncertainty, probabilistic algorithms, game theory, and theoretical computer science. Intelligent robots and autonomous systems depend on algorithms that efficiently realize functionalities ranging from perception to decision making, from motion planning to control. The works collected in this SPAR book represent the state of the art in algorithmic robotics. They originate from papers accepted to the 14th International Workshop on the Algorithmic Foundations of Robotics (WAFR), traditionally a biannual, single-track meeting of leading researchers in the field of robotics. WAFR has always served as a premiere venue for the publication of some of robotics' most important, fundamental, and lasting algorithmic contributions, ensuring the rapid circulation of new ideas. Though an in-person meeting was planned for June 15-17, 2020, in Oulu, Finland, the event ended up being canceled owing to the infeasibility of international travel during the global COVID-19 crisis.

This book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor's laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.

Freud was addicted to cocaine and nicotine, Jung was psychotic for several years, and Margaret Mead remained closeted throughout her lifetime. Yet, adversities notwithstanding, they all made monumental contributions that still shape our view on ourselves and the world. This book includes biographies of fifteen modern explorers of the mind who altered the course of history. All of them were wounded healers who made great discoveries while struggling with traumatic life crises and emotional problems in their personal lives. Full of unexpected twists and turns, their life stories alone are worthy of our attention. In linking their maladies with their creativity, showing the vulnerable and human side of these giants, this book makes the greats approachable and illuminates their scientific findings through narrating their life stories.

This book presents a detailed overview of the design, formatting, application, and development of microfluidic chips in the context of cell biology research, enumerating each element involved in microfluidics-based cell analysis, discussing its history, status quo, and future prospects, It also offers an extensive review of the research completed in the past decade, including numerous color figures. The individual chapters are based on the respective authors' studies and experiences, providing tips from the frontline to help researchers overcome bottlenecks in their own work. It highlights a number of cutting-edge techniques, such as 3D cell culture, microfluidic droplet technique, and microfluidic chip-mass spectrometry interfaces, offering a first-hand impression of the latest trends in the field and suggesting new research directions. Serving as both an elementary introduction and advanced guidebook, the book interests and inspires scholars and students who are currently studying microfluidics-based cell analysis methods as well as those who wish to do so.

No one reacts or responds to a drug in exactly the same way, just as no two persons are exactly alike. Individual and ethnic differences in drug response have been consistently found in clinical practice. This book covers all the important factors that explain how and why drug treatments used in psychiatry affect individuals and ethnic groups differently. It will increase understanding of how biological differences interact with social, cultural and environmental factors to bring about overall effects of medications, particularly in individuals from various ethnicities. This book uniquely brings these varied aspects together to consider a holistic approach to drug therapy across diverse biological make-up and cultures. This information has direct practical use in the clinical setting.

No one reacts or responds to a drug in exactly the same way, just as no two persons are exactly alike. Individual and ethnic differences in drug response have been consistently found in clinical practice. This book covers all the important factors that explain how and why drug treatments used in psychiatry affect individuals and ethnic groups differently. It will increase understanding of how biological differences interact with social, cultural and environmental factors to bring about overall effects of medications, particularly in individuals from various ethnicities. This book uniquely brings these varied aspects together to consider a holistic approach to drug therapy across diverse biological make-up and cultures. This information has direct practical use in the clinical setting.