An extensively researched account of the ups and downs in the history of uppers Uppers. Crank. Bennies. Dexies. Greenies. Black Beauties. Purple Hearts. Crystal. Ice. And, of course, Speed. Whatever their street names at the moment, amphetamines have been an insistent force in American life since they were marketed as the original antidepressants in the 1930s. On Speed tells the remarkable story of their rise, their fall, and their surprising resurgence. Along the way, it discusses the influence of pharmaceutical marketing on medicine, the evolving scientific understanding of how the human brain works, the role of drugs in maintaining the social order, and the centrality of pills in American life. Above all, however, this is a highly readable biography of a very popular drug. And it is a riveting story. Incorporating extensive new research, On Speed describes the ups and downs (fittingly, there are mostly ups) in the history of amphetamines, and their remarkable pervasiveness. For example, at the same time that amphetamines were becoming part of the diet of many GIs in World War II, an amphetamine-abusing counterculture began to flourish among civilians. In the 1950s, psychiatrists and family doctors alike prescribed amphetamines for a wide variety of ailments, from mental disorders to obesity to emotional distress. By the late 1960s, speed had become a fixture in everyday life: up to ten percent of Americans were thought to be using amphetamines at least occasionally. Although their use was regulated in the 1970s, it didn't take long for amphetamines to make a major comeback, with the discovery of Attention Deficit Disorder and the role that one drug in the amphetamine family-Ritalin-could play in treating it. Today's most popular diet-assistance drugs differ little from the diet pills of years gone by, still speed at their core. And some of our most popular recreational drugs-including the "mellow" drug, Ecstasy-are also amphetamines. Whether we want to admit it or not, writes Rasmussen, we're still a nation on speed.

An extensively researched account of the ups and downs in the history of uppers Uppers. Crank. Bennies. Dexies. Greenies. Black Beauties. Purple Hearts. Crystal. Ice. And, of course, Speed. Whatever their street names at the moment, amphetamines have been an insistent force in American life since they were marketed as the original antidepressants in the 1930s. On Speed tells the remarkable story of their rise, their fall, and their surprising resurgence. Along the way, it discusses the influence of pharmaceutical marketing on medicine, the evolving scientific understanding of how the human brain works, the role of drugs in maintaining the social order, and the centrality of pills in American life. Above all, however, this is a highly readable biography of a very popular drug. And it is a riveting story. Incorporating extensive new research, On Speed describes the ups and downs (fittingly, there are mostly ups) in the history of amphetamines, and their remarkable pervasiveness. For example, at the same time that amphetamines were becoming part of the diet of many GIs in World War II, an amphetamine-abusing counterculture began to flourish among civilians. In the 1950s, psychiatrists and family doctors alike prescribed amphetamines for a wide variety of ailments, from mental disorders to obesity to emotional distress. By the late 1960s, speed had become a fixture in everyday life: up to ten percent of Americans were thought to be using amphetamines at least occasionally. Although their use was regulated in the 1970s, it didn't take long for amphetamines to make a major comeback, with the discovery of Attention Deficit Disorder and the role that one drug in the amphetamine family-Ritalin-could play in treating it. Today's most popular diet-assistance drugs differ little from the diet pills of years gone by, still speed at their core. And some of our most popular recreational drugs-including the "mellow" drug, Ecstasy-are also amphetamines. Whether we want to admit it or not, writes Rasmussen, we're still a nation on speed.

Two major questions motivate this study: How do new devices get taken up as experimental systems by scientists? How does the adoption of new instruments affect scientific knowledge? Many ramifications emerge from these two simple questions. Among these are historical questions about how, by whom, and why new instruments are introduced, or about how another, different set of instruments might be adopted given alternative social and cultural circumstances. Philosophical questions include the ways in which scientific understanding of the world depends on scientists' instruments and techniques. Sociological questions concern such issues as how the organization of work within disciplines and laboratories and other scientific institutions may depend on the equipment employed.
All these questions are addressed in this book, which draws upon a range of archival sources as well as published scientific literature, through a detailed historical treatment of the electron microscope's introduction and early impact on the life sciences. The author first describes the introduction of the electron microscope during the World War II years, and then traces its influence on the subsequent divergence of several life sciences research traditions, including what came to constitute cell biology. The historical evidence is discussed in the light of recent discussions on the origin and nature of molecular biology, the importance of new instruments in the postwar life sciences, and the nature of research traditions, among other issues.
Building on the pragmatist tradition, the author also advances an original philosophical argument on the relation of experimental technology to scientific change, arguing that matters of scientific fact (and also matters of the social organization of science) are only settled through agreement on standardized "methods of inquiry."

Two major questions motivate this study: How do new devices get taken up as experimental systems by scientists? How does the adoption of new instruments affect scientific knowledge? Many ramifications emerge from these two simple questions. Among these are historical questions about how, by whom, and why new instruments are introduced, or about how another, different set of instruments might be adopted given alternative social and cultural circumstances. Philosophical questions include the ways in which scientific understanding of the world depends on scientists instruments and techniques. Sociological questions concern such issues as how the organization of work within disciplines and laboratories and other scientific institutions may depend on the equipment employed. All these questions are addressed in this book, which draws upon a range of archival sources as well as published scientific literature, through a detailed historical treatment of the electron microscope s introduction and early impact on the life sciences. The author first describes the introduction of the electron microscope during the World War II years, and then traces its influence on the subsequent divergence of several life sciences research traditions, including what came to constitute cell biology. The historical evidence is discussed in the light of recent discussions on the origin and nature of molecular biology, the importance of new instruments in the postwar life sciences, and the nature of research traditions, among other issues.