The chapters of this book synthesize papers on the inter-related topics of urban economics, real estate, transportation and public policy and include applied and empirical research on a variety of sub-topics. These include innovative econometric techniques that are applied to timely problems, such as impacts of flooding in Vancouver, BC Canada on property values; and the determinants of traffic accident fatalities in the US and in Thailand. There are also chapters on more policy-oriented issues, such as the impacts of Covid-19 on real estate in Toronto, ON Canada. The book will appeal to the interest of academics, policy-makers, planners, and geographers.

Bringing together essays, research studies and other material written over the past two decades, this book traces through them a history of political and intellectual debates on the left and in cultural studies, around central issues of education, labour and the youth question. An argument is made for linking the cultural, structural and autobiographical dimensions of the youth question in order to engage educationally with the burden of representation which young people are made to carry via race, class and sexuality in the postmodern world. The book includes three major unpublished pieces and an introduction which discusses the nature of the collection, and sets it in both a personal and political context.

In this book, a case study of a humanistic reading of an essential evolutionary theorist, George C. Williams (May 12, 1926-September 8, 2010), the author contends that certain classic works of evolutionary theory and history are the most important nature writing of recent times. What it means to be scientifically literate-is essential for humanistic scholars, who must ground themselves with literary reading of scientific texts. As the most influential American evolutionary theorist of the second half of the twentieth century, Williams masters critique, frames questions about adaptation and natural selection, and answers in a plain, aphoristic writing style. Williams aims for parsimony-to "recognize adaptation at the level necessitated by the facts and no higher"-through a minimalist writing style. This voice articulates a powerful process that operates at very low levels by blind and selfish chance at the expense of its designed products, using purely trial and error.

"With each passing day, Pakistan becomes an even more crucial player in world affairs. Home of the world's second-largest Muslim population, epicenter of the global jihad, location of perhaps the planet's most dangerous borderlands, and armed with nuclear weapons, this South Asian nation will go a long way toward determining what the world looks like ten years from now. The Future of Pakistan presents and evaluates several scenarios for how the country will develop, evolve, and act in the near future, as well as the geopolitical implications of each. Led by renowned South Asia expert Stephen P. Cohen, a team of authoritative contributors looks at several pieces of the Pakistan puzzle. The book begins with Cohen's broad yet detailed overview of Pakistan, placing it within the context of current-day geopolitics and international economics. Cohen's piece is then followed by a number of shorter, more tightly focused essays addressing more specific issues of concern. Cohen's fellow contributors hail from America, Europe, India, and Pakistan itself, giving the book a uniquely international and comparative perspective. They address critical factors such as the role and impact of radical groups and militants, developments in specific key regions such as Punjab and the rugged frontier with Afghanistan, and the influence of-and interactions with-India, Pakistan's archrival since birth. The book also breaks down relations with other international powers such as China and the United States. The all-important military and internal security apparatus come under scrutiny, as do rapidly morphing social and gender issues. Political and party developments are examined along with the often amorphous division of power between Islamabad and the nation's regions and local powers. Uncertainty about Pakistan's trajectory persists. The Future of Pakistan helps us understand the current circumstances, the relevant actors and their motivation, the critical issues at hand, the different outcomes they might produce, and what it all means for Pakistanis, Indians, the United States, and the entire world. Praise for the work of Stephen P. Cohen The Idea of Pakistan: ""The intellectual power and rare insight with which Cohen breaks through the complexity of the subject rivals that of classics that have explained other societies posting a comparable challenge to understanding.""- Middle East Journal India: Emerging Power: ""In light of the events of September 11, 2001, Cohen's perceptive, insightful, and balanced account of emergent India will be essential reading for U.S. foreign policymakers, scholars, and informed citizens.""- Choice "

India and Pakistan, nuclear neighbors and rivals, fought the last of three major wars in 1971. Far from peaceful, however, the period since then has been "one long crisis, punctuated by periods of peace." The long-disputed Kashmir issue continues to be both a cause and consequence of India-Pakistan hostility. Four Crises and a Peace Process focuses on four contained conflicts on the subcontinent: the Brasstacks Crisis of 1986?1987, the Compound Crisis of 1990, the Kargil Conflict of 1999, and the Border Confrontation of 2001?2002. Authors P.R. Chari, Pervaiz Iqbal Cheema, and Brookings senior fellow Stephen P. Cohen explain the underlying causes of these crises, their consequences, the lessons that can be learned, and the American role in each. The four crises are notable because any one of them could have escalated to a large-scale conflict, or even all-out war, and three took place after India and Pakistan had gone nuclear. Looking for larger trends of peace and conflict in the region, the authors consider these incidents as cases of attempted conflict resolution, as instances of limited war by nuclear-armed nations, and as examples of intervention and engagement by the United States and China. They analyze the reactions of Indian, Pakistani, and international media and assess the two countries' decision-making processes. Fo "ur Crises and a Peace Process e"xplains how these crises have affected regional and international policy and evaluates the prospects for lasting peace in South Asia.

First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

India has long been motivated to modernize its military, and it now has the resources. But so far, the drive to rebuild has lacked a critical component --strategic military planning. India's approach of arming without strategic purpose remains viable, however, as it seeks great-power accommodation of its rise and does not want to appear threatening. What should we anticipate from this effort in the future, and what are the likely ramifications? Stephen Cohen and Sunil Dasgupta answer those crucial questions in a book so timely that it reached number two on the nonfiction bestseller list in India.

"Two years after the publication of "Arming without Aiming," our view is that India's strategic restraint and its consequent institutional arrangement remain in place. We do not want to predict that India's military-strategic restraint will last forever, but we do expect that the deeper problems in Indian defense policy will continue to slow down military modernization." --from the preface to the paperback edition

This book provides a detailed examination of the compound crisis between India and Pakistan that brought the region to the brink of a nuclear war in 1990. Placing the crisis in the context of concurrent international events such as the fall of the Soviet Union, the authors draw out the lesson for present-day South Asian affairs. The book also makes a significant contribution to the debates on the role of nuclear weapons, confidence and security building strategies and the place of ethnicity in contemporary international relations.

In mid-March 1992, a group of forty scholars, journalists, strategists, and government officials met in Kathmandu, Nepal, to assess the post-Cold War world. The meeting marked both a summing up and a beginning. Many of the conference participants had been associated at one time or another with the Program in Arms Control, Disarmament, and International Security (A CD IS) at the University of lllinois at Urbana-Champaign. Founded in 1978, ACDIS had from its very first year recruited scholars from South Asia (and scholars working on South Asia). Much of this work was supported by a continuing grant from the Ford Foundation (which also contributed major support for the Kathmandu meeting), but lllinois was also "home" for a number of Fulbright and Asia Foundation grantees.1 The meeting in Kathmandu provided an opportunity for these individuals to again meet with each other and with faculty and staff associated with ACDIS.

This book provides a detailed examination of the compound crisis between India and Pakistan that brought the region to the brink of a nuclear war in 1990. Placing the crisis in the context of concurrent international events such as the fall of the Soviet Union, the authors draw out the lesson for present-day South Asian affairs. The book also makes a significant contribution to the debates on the role of nuclear weapons, confidence and security building strategies and the place of ethnicity in contemporary international relations.

eBook available with sample pages: 0203475186

A study which attempts to formulate an anthropological approach to consciousness. This text explores the importance of the conscious self, and of the conscious collectively, in the construction and interpretation of social relations and process. It asks the question: to what extent is the consciousness of individuals modelled by the cultures and social structures within which they live?.

Anthony Cohen makes a distinct break with earlier approaches to the study of community, which treated the subject in largely structural terms. His view is interpretive and experiential, seeing the community as a cultural field with a complex of symbols whose meanings vary among its members. He delineates a concept applicable to local and ethnic communities through which people see themselves as belonging to society. The emphasis on boundary is sensitive to the circumstances in which people become aware of the implications of belonging to a community, and describes how they symbolise and utilise these boundaries to give substance to their values and identities.

The understanding of pain has undergone extraordinary development over the last 25 years. Half of all medical visits are initiated because of pain. The need for all clinicians and trainees to have a foundational knowledge of pain has become more critically important than ever. Not surprisingly, most books on pain medicine are almost all written by "pain management doctors," physicians who've trained in "pain medicine" and devote their lives to treating pain. However, the burden of pain extends to all doctors, not just those who treat it every day. Managing Pain: Essentials of Diagnosis and Treatment offers a fundamental guide on the diagnosis and therapy of frequently encountered pain conditions for non-pain physicians and clinicians. Written using easily-accessible language, this book first reviews the basics of opioids and other therapies, including psychotherapy and complementary modalities. The second part of the book presents clinically-relevant cases chosen to reflect those conditions most frequently encountered by primary care providers. Edited by world-renowned experts in pain medicine, with many chapters written by non-pain physicians who are experts in their respective specialties, Managing Pain: Essentials of Diagnosis and Treatment is a useful guide for the non-pain-trained healthcare provider who is on the frontlines treating chronic pain.

Endocrinology and Metabolism: Progress in Research and Clinical Prac tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata gems."

In the middle of the 17th century, the great French philosopher Rene Descartes wrote (L'Homme, J. Le Gras, Paris, 1669) that a suitable stimulation of the brain results in two types of "movements": exterior movements, designed to seek desirable ends and to avoid undesirable or harmful ones and interior movements or "passions" which through the release of "animal spirits" regulate the heart, the liver, and other organs. When it appears appropriate to meet a threat with force, the passion of rage causes the release of strong spirits, whereas when avoidance appears to be the better choice, the passion of fear causes the brain to release weak spirits. We do not know what influence, if any, Descartes had on the thinking of Walter B. Cannon (Bodily Changes in Pain, Hunger, Fear and Rage, Appleton and Co. , New York, 1920), of Hans Selye (The Story of the Adaptation Syndrome, Acta, Inc. , Montreal, 1952), ofG. W. Harris or of R. Guillemin (Hypothalamic-Hypophysial Interrelationships. A Sym posium. c. c. Thomas, Springfield, 1956), but it is interesting to reflect upon the durable value of great ideas which constantly resurface even if modified by other ideas and by new techniques, as if propelled by a preordained intellectual imperative.

In the last decade, it has become increasingly evident that the clini- cal and morphologic changes underlying many of the complications of diabetes, including cataract formation, retinopathy, nephropathy, neuropathy, and macrovascular disease, are preceded by a variety of disturbances of biochemical and physiologic origin. Dr. Cohen has recently written a superb monograph, entitled Diabetes and Protein Glycosylation: Measurement and Biologic Relevance, in which she thoroughly explores how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for main- tenance of long-term euglycemia. In the present volume, The Polyol Paradigm and Complications of Diabetes, she reviews, in a most succinct and thorough manner, how another biochemical mechan- ism, involving the polyol pathway, is involved in the pathogenesis of such diabetes complications as retinopathy, neuropathy, nephropa- thy, and cataract formation. Dr. Cohen gives us a clearly written and comprehensive mono- graph, reviewing the chemistry of the polyol pathway and of the aldose reductase inhibitors, and the pathophysiologic significance of increased polyol pathway activity in a variety of tissues affected by Vlll Foreword diabetes mellitus. She insightfully describes the relationship of increased polyol pathway activity to altered metabolism of inositol- containing phospholipids and to changes in various tissue concentra- tions of myo-inositol. Finally, she provides us with a careful review of the existing experimental and clinical studies with a variety of different aldose reductase inhibitors that have been and are being performed in the hope of preventing or reversing long-term compli- cations of diabetes.

The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably concerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background knowledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory textbooks or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook of biology.

For years, Americans have seen India as a giant but inept state. That negative image is now obsolete. After a decade of drift and uncertainty, India is taking its expected place as one of the three major states of Asia. Its pluralist, secular democracy has allowed the rise of hitherto deprived castes and ethnic communities. Economic liberalization is gathering steam, with six percent annual growth and annual exports in excess of $30 billion. India also has a modest capacity to project military power. The country will soon have a two-carrier navy and it is developing a nuclear-armed missile capable of reaching all of Asia. This landmark book provides the first comprehensive assessment of India as a political and strategic power since India's nuclear tests, its 1999 war with Pakistan, and its breakthrough economic achievements. Stephen P. Cohen examines the domestic and international causes of India's "emergence," he discusses the way social structure and tradition shape Delhi's perceptions of the world, and he explores India's relations with neighboring Pakistan and China, as well as the United States. Cohen argues that American policy needs to be adjusted to cope with a rising India -and that a relationship well short of alliance, but far more intimate than in the past, is appropriate for both countries.

Accessible, concise, and clinically focused, Essentials of Pain Medicine, 4th Edition, by Drs. Honorio T. Benzon, Srinivasa N. Raja, Scott M. Fishman, Spencer S. Liu, and Steven P. Cohen, presents a complete, full-color overview of today's theory and practice of pain medicine and regional anesthesia. It provides practical guidance on the full range of today's pharmacologic, interventional, neuromodulative, physiotherapeutic, and psychological management options for the evaluation, treatment, and rehabilitation of persons in pain. Covers all you need to know to stay up to date in practice and excel at examinations - everything from basic considerations through local anesthetics, nerve block techniques, acupuncture, cancer pain, and much more. Uses a practical, quick-reference format with short, easy-to-read chapters. Presents the management of pain for every setting where it is practiced, including the emergency room, the critical care unit, and the pain clinic. Features hundreds of diagrams, illustrations, summary charts and tables that clarify key information and injection techniques - now in full color for the first time. Includes the latest best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics). Discusses recent global developments regarding opioid induced hyperalgesia, addiction and substance abuse, neuromodulation and pain management, and identification of specific targets for molecular pain. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Anthony Cohen makes a distinct break with earlier approaches to the study of community, which treated the subject in largely structural terms. His view is interpretive and experiential, seeing the community as a cultural field with a complex of symbols whose meanings vary among its members. He delineates a concept applicable to local and ethnic communities through which people see themselves as belonging to society. The emphasis on boundary is sensitive to the circumstances in which people become aware of the implications of belonging to a community, and describes how they symbolise and utilise these boundaries to give substance to their values and identities.

eBook available with sample pages: 0203131681

Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed. Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy. Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer. Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment. Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care. Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies - treatments that are being recognized for adverse kidney effects. Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Cancer and the Kidney covers the challenging overlap area of nephrology and oncology. Kidney problems in cancer patients, and cancer that affects kidney patients, are both very real clinical issues in medicine. For example, cancer is a common complication of kidney transplantation, and up to half of all survivors of bone marrow transplant may develop chronic kidney disease.
Since publication of the first edition in 2005, there have been many changes in this area. These include the recognition of chronic kidney disease after uninephrectomy for cancer, the occurrence of medication toxicities of the EGFR antagonists and of the VEGF antagonists, and changes in the approach to multiple myeloma. In this new edition, the primary authors cover diverse subjects in this area, ranging from assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween. Each chapter starts with a case study to ensure a practical focus, and there are numerous illustrations throughout. Specialists and trainees in nephrology and in oncology will find it a useful starting point and reference, as will physician assistants and nurse practitioners who work in these fields.