The Polyol Paradigm and Complications of Diabetes (Paperback, Softcover reprint of the original 1st ed. 1987)

In the last decade, it has become increasingly evident that the clini- cal and morphologic changes underlying many of the complications of diabetes, including cataract formation, retinopathy, nephropathy, neuropathy, and macrovascular disease, are preceded by a variety of disturbances of biochemical and physiologic origin. Dr. Cohen has recently written a superb monograph, entitled Diabetes and Protein Glycosylation: Measurement and Biologic Relevance, in which she thoroughly explores how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for main- tenance of long-term euglycemia. In the present volume, The Polyol Paradigm and Complications of Diabetes, she reviews, in a most succinct and thorough manner, how another biochemical mechan- ism, involving the polyol pathway, is involved in the pathogenesis of such diabetes complications as retinopathy, neuropathy, nephropa- thy, and cataract formation. Dr. Cohen gives us a clearly written and comprehensive mono- graph, reviewing the chemistry of the polyol pathway and of the aldose reductase inhibitors, and the pathophysiologic significance of increased polyol pathway activity in a variety of tissues affected by Vlll Foreword diabetes mellitus. She insightfully describes the relationship of increased polyol pathway activity to altered metabolism of inositol- containing phospholipids and to changes in various tissue concentra- tions of myo-inositol. Finally, she provides us with a careful review of the existing experimental and clinical studies with a variety of different aldose reductase inhibitors that have been and are being performed in the hope of preventing or reversing long-term compli- cations of diabetes.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	October 2011
First published:	1987
Foreword by:	Harold Rifkin
Authors:	Margo P Cohen
Dimensions:	235 x 155 x 8mm (L x W x T)
Format:	Paperback
Pages:	143
Edition:	Softcover reprint of the original 1st ed. 1987
ISBN-13:	978-1-4612-9108-4
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Metabolism Books > Medicine > Clinical & internal medicine > Endocrinology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	1-4612-9108-9
Barcode:	9781461291084

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