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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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The Polyol Paradigm and Complications of Diabetes (Paperback, Softcover reprint of the original 1st ed. 1987)
Loot Price: R1,482
Discovery Miles 14 820
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The Polyol Paradigm and Complications of Diabetes (Paperback, Softcover reprint of the original 1st ed. 1987)
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In the last decade, it has become increasingly evident that the
clini- cal and morphologic changes underlying many of the
complications of diabetes, including cataract formation,
retinopathy, nephropathy, neuropathy, and macrovascular disease,
are preceded by a variety of disturbances of biochemical and
physiologic origin. Dr. Cohen has recently written a superb
monograph, entitled Diabetes and Protein Glycosylation: Measurement
and Biologic Relevance, in which she thoroughly explores how
enhanced nonenzymatic glycosylation in uncontrolled diabetes
underscores the pressing need for main- tenance of long-term
euglycemia. In the present volume, The Polyol Paradigm and
Complications of Diabetes, she reviews, in a most succinct and
thorough manner, how another biochemical mechan- ism, involving the
polyol pathway, is involved in the pathogenesis of such diabetes
complications as retinopathy, neuropathy, nephropa- thy, and
cataract formation. Dr. Cohen gives us a clearly written and
comprehensive mono- graph, reviewing the chemistry of the polyol
pathway and of the aldose reductase inhibitors, and the
pathophysiologic significance of increased polyol pathway activity
in a variety of tissues affected by Vlll Foreword diabetes
mellitus. She insightfully describes the relationship of increased
polyol pathway activity to altered metabolism of inositol-
containing phospholipids and to changes in various tissue
concentra- tions of myo-inositol. Finally, she provides us with a
careful review of the existing experimental and clinical studies
with a variety of different aldose reductase inhibitors that have
been and are being performed in the hope of preventing or reversing
long-term compli- cations of diabetes.
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