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This work offers succinct, medically-oriented coverage of biochemistry, examining biologically important materials and presenting the properties of nucleic acids as well as nucleic acid metabolism. Each metabolic process is integrated in a review of overall energy metabolism, diabetes and starvation. A solutions manual is available to instructors only.
Covers fundamentals of peptide and protein drug delivery. This reference/text includes such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics as well as bioavailability from routes of administration.
The aim of this guide is to provide clinicians with practical reference for the management of hypertensive patients with other cardiovascular risk factors, which originate from impaired metabolic functions. With the aid of carefully selected, paradigmatic case studies, the physician will find sound advice for the best approach to common but often under-recognized clinical situations, and answers to practical questions that arise when a specific condition is not directly addressed in the guidelines. Question-and-answer sections will help the reader to identify at a glance the most complex steps in the diagnostic and therapeutic process. In a "real world" clinical setting, the hypertensive patient rarely presents with hypertension as the only cardiovascular risk factor, and is more likely to be affected by other metabolic risk factors, such as impairment of lipid metabolism, glucose homeostasis, and purine metabolism, and by overweight or obesity. These cases will serve as a basis for analyzing best practice, highlighting problems in diagnosis and treatment, and selecting the most appropriate management of patients with metabolic risk factors in everyday practice.
This book presents the latest insights into the role of nutrition and diet in the pathophysiology and clinical outcome of many digestive diseases, including gastrointestinal cancer, gastroesophageal reflux, gastroparesis, diverticular disease, inflammatory bowel disease, irritable bowel syndrome, obesity, autism and other severe neurological diseases, and liver disease. The editors have aimed to build upon the dissemination of scientific information on human health and nutrition that took place at Expo Milano 2015 (theme: "Feeding the Planet, Energy for Life") by bringing together distinguished experts in gastroenterology from prestigious Italian universities and hospital centers to tackle novel topics in human nutrition and diet. In the context of modern, high tech gastroenterology, it is easy to neglect or underplay the importance of factors such as nutrition. Readers will find this book to be an excellent source of the most recently acquired scientific knowledge on the topic, and a worthy legacy of Expo Milano 2015.
This work is recognised as the standard textbook for professionals involved in the diagnosis and management of inborn errors of metabolism (IEM) and an essential resource in this multidisciplinary field. For the 6th edition all 43 chapters have been newly written or revised by authors with particular expertise in their subject areas. Contents: A clinical and biochemical approach to the recognition and diagnosis of IEM with algorithms to symptoms, signs, and syndromes in patients of all ages; Emergency treatments; Medications - Separate comprehensive sections on IEM of: Carbohydrates; Mitochondrial Energy; Amino and organic acids; Vitamin-responsive defects; Neurotransmitter and Small peptides, Lipid and Bile Acids; Nucleic Acid and Heme; Organelles - Disorders affecting the synthesis and remodelling of complex lipids and fatty acid homeostasis are now included.
This book examines the biological aspects of bile acid analysis and their clinical applications, providing readers with an overview of cutting-edge discussions on Bile Acid research and diseases. It begins with detailed discussions on the biological aspects of bile acid, with chapters examining bile acid from various perspectives, from its metabolism to its use in therapeutic agents. Subsequent chapters focus on diseases involving bile acid abnormalities, and specific applications are addressed concerning gallstones, cholestatic liver disease, NAFLD/NASH, hepatitis, pancreatitis, esophageal cancer and colon cancer. In keeping with the book's integrated approach, the Editor has gathered a broad range of eminent scholars and practitioners to provide a comprehensive review of modern bile acid research. The book offers clinical physicians, basic researchers and postgraduate students essential insights into cutting-edge research and paves the way for further research.
Providing the most current information on the function of human growth hormone (GH) and the consequences of its deficiency, this practical yet comprehensive text is divided into three sections. Part one describes the mechanisms of GH secretion and action, including the physiology of GH and its regulation by sex steroids and thyroid hormones, the effects of both under nutrition and obesity on GH secretion, and the metabolic effects of human recombinant GH therapy. The second section covers diagnostic strategies and tests for GH deficiency in both children and adults, including MRI of the pituitary. The final section describes the different etiologies of GH deficiency, from molecular mechanisms and gene abnormalities to cranial radiation and traumatic brain injury, along with syndromes related to this deficiency. Presenting underlying mechanisms and pathologies, as well as diagnostic methods, Growth Hormone Deficiency will provide the most up-to-date essential information and evidence on this condition for the clinical endocrinologist.
Metabolism at a Glance presents a concise, illustrated summary of metabolism in health and disease. This essential text is progressively appropriate for introductory through to advanced medical and biochemistry courses. It also provides a succinct review of inborn errors of metabolism, and reference for postgraduate medical practitioners and biomedical scientists who need a resource to quickly refresh their knowledge. Fully updated and extensively illustrated, this new edition of Metabolism at a Glance is now in full colour throughout, and includes new coverage of sports biochemistry; the metabolism of lipids, carbohydrates and cholesterol; glyceroneogenesis, -oxidation and -oxidation of fatty acids. It also features the overlooked Krebs Uric Acid Cycle . Metabolism at a Glance offers an accessible introduction to metabolism, and is ideal as a revision aid for students preparing for undergraduate and USMLE Step 1 exams.
This book is intended as a source of information for the many scientists who now enter the growing research field of vitamin A in health and disease, reviewing the epidemiological aspects related to vitamin A.
The 3rd edition of Understanding Diabetes has been updated with new and additional information. Includes a general definition of diabetes.Describes how diabetes is diagnosed. Illustrates what happens in diabetes and insulin action in a body cell. Also describes the following types of diabetes: type I diabetes type 2 diabetes including factors causing insulin resistance pre-diabetes prenatal diabetes Discusses diabetes in youth.Lists symptoms and risk factors. And includes tips for successful diabetes management. Available in the following size and formats: 20" x 26" heavy paper ISBN 978-14698-9489-8 20" x 26" laminated with eyelets at top corners ISBN 978-14698-9492-8 printed in USA
This concise, case-based text discusses the current state of the art for the diagnosis and management of metabolic bones diseases. Each chapter opens with a unique case presentation and utilizes a consistent format that includes relevant anatomy, physiology, and pathophysiology as well as examination, treatment approaches and clinical outcomes. Topics covered include osteoporosis, rickets and osteomalacia, hypoparathyroidism and pseudohypoparathyroidism, osteogenesis imperfecta, Paget's disease of bone, calcium and phosphorous disorders, hypophosphatasia, sclerotic bone disorders, fibrous and osteochondroplasia, and other malignancies of bone. Written and edited by experts in the field, Metabolic Bone Diseases is a valuable resource for practicing endocrinologists, rheumatologists and orthopedic surgeons, residents and fellows.
As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional, and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics, and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians, and all other health professionals who treat adolescent obesity.
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Have you ever thought to yourself, "I think I might have a thyroid
problem. I'm tired all the time, no matter how much I exercise, I
can't seem to lose weight, my hair's falling out, and overall I
just feel blah." If so, it is essential that you explore the very
real possibility that indeed, you do have hypothyroidism. In
"Hypothyroidism, Health & Happiness, " Dr. Steven Hotze reveals
how commonly hypothyroidism is overlooked, misdiagnosed, and
mistreated in women and men, and gives you just the information you
need to prepare yourself to obtain help.
Despite the gains of the women's movement, women are still judged by what they look like--and men, by what they do. Fat--A Fate Worse Than Death? offers hardy resistance to the narrow, random, and irrational appearance standards set for American women through an approach that is personal, eclectic, courageous, and funny. If you are interested in giving up your diet, throwing out your scales, and concentrating on who you are on a deeper level, this book will show you how to accept, appreciate, and even love your body Using statistics, research, anecdotes, and personal experiences, Fat--A Fate Worse Than Death? explores how appearance standards have built a prison for women. With the book's helpful advice, reading suggestions, and list of more than 100 ways to fight looksism, sexism, ageism, and racism, you will learn to express your rights and needs, regardless of your shape or size, and tear down those prison walls. Designed to transcend the boundaries between the personal and the political, Fat--A Fate Worse Than Death? discusses: examples of how weight and size constitute the last socially accepted prejudice the national "War on Fat" counteracting societal influences that support weight preoccupation connection between appearance standards for older women and large women nurturing your body resisting male-defined standards of beauty for women the myth of diets and dieting how the body resists weight loss how women are disempowered by concentration on weight and appearance how concentrating on appearance leaves real-life issues unaddressed how feeling bad about yourself can turn you into a willing consumerFeminists, faculty and students of women's studies programs, aging women, women of radical politics, and other concerned women and men will find that Fat--A Fate Worse Than Death? states explicitly how women are kept powerless by subscribing to cultural and social edicts on physical appearance. Don?t live silently in a society that degrades and discounts women because of their physical stature and don?t let obsession with thinness keep you passive, docile, and unable to give your energy to things that really need your passion and intelligence. Read this book and learn to not only value yourself for who you are, but also to counteract American culture's equality-denying prejudices and practices.
Diabetic nephropathy is the most common cause of chronic kidney failure in the United States. The Diabetic Nephropathy pocketcard Set contains up to date information to fit in a lab coat for daily use in a clinical setting. *Diagnostic Algorithm where diabetic nephropathy is suspected * Important differential diagnoses with relevant diagnostic criteria for quick exclusion of other types * Extensive therapy management as recommended by current guidelines * Tabular overview of antidiabetic drugs and dosages in patients with impaired kidney function * Overview of various methods of GFR estimation * Evaluation and treatment of risk factors and nephroprotective measures For endocrinologists, family practitioners and physicians in hospitals and medical practices.
From a reassessment of osteoporosis to contributing factors, clinical applications of antiosteoporotic agents, and rehabilitation, this book examines various aspects of the disease and its treatment. Edited and written from an orthopedic perspective, it approaches osteoporosis as both a metabolic disease and a locomotive syndrome. As orthopedic surgeons in Japan are responsible for pharmacotherapy, surgery, and pain control, the authors pursue a comprehensive approach, focusing especially on the effect on muscles and on fracture operation rather than expanding the scope to bone density. Osteoporosis in Orthopedics provides extensive content and insights for clinicians, researchers, medical students, and post-docs specializing in osteoporosis. It also offers a valuable resource for orthopedic and spine surgeons who need extensive knowledge of osteoporosis and bone metabolism in the context of patient care.
Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.
This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor's family in development and human disease. Following are in-depth analyses of each family's receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.
This book addresses why and how the aging process is accelerated under diabetes, providing valuable and comprehensive information for the management of various types of diabetes- and aging-related disorders. Since several papers have shown that average life span and healthy life expectancy are reduced in diabetic patients, especially in those with a long history of disease, the early detection and treatment of diabetes-related complications are urgently needed in order to slow the aging process and help people successfully live with diabetes. Each chapter of this book addresses a specific diabetes and aging-related complication. The topics covered include not only diabetic vascular complications, the leading causes of morbidities and high mortality rates in both type 1 and type 2 diabetic patients, but also other aging-related complications such as Alzheimer's disease, osteoporosis, periodontitis and cancer growth and metastasis. Experts on each topic discuss the background of the aging process and methods for coping with diabetes-related complications. The book as a whole, as well as the individual chapters, offer a valuable resource for researchers and practitioners in the fields of diabetic studies, gerontology, and aging science.
Metabolism, behaviour, sleep, mood swings, the immune system, fighting, fleeing, puberty and sex: these are just a few of the things our bodies control with hormones. Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein takes us on a journey through the unusual history of these potent chemicals from a basement filled with jarred nineteenth-century brains to a twenty-first-century hormone clinic in Los Angeles. Brimming with fascinating anecdotes, illuminating new medical research and humorous details, Aroused introduces the leading scientists who made life-changing discoveries about the hormone imbalances that ail us, as well as the charlatans who used those discoveries to peddle false remedies.
This indispensable pocket guide helps the practitioner prioritize nutrition interventions for lipid disorders, hypertension, diabetes, and weight management that will be most effective in reducing risk of disease complications. The latest authoritative guidelines are addressed, including recommendations from the Evidence Analysis Library, American Heart Association, American College of Cardiology, Eighth Joint National Committee, National Lipid Association, American Diabetes Association, Obesity Society, and Dietary Guidelines Advisory Committee. Organized according to the Nutrition Care Process, this comprehensive guide includes assessment tools, sample PES (problem, etiology, and signs and symptoms) statements, guidelines for nutrition education, and more. Handy appendixes with common formulas and tools make this a true, one-stop pocket guide.
This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas. Timely and up-to-date, it opens with a review of the historical aspects of prolactin research and a discussion of pituitary anatomy and physiology. Several chapters examine basic and translational aspects of prolactin physiology, focusing on recent developments and future directions. The main portion of the book is comprised of chapters presenting the clinical aspects of prolactin excess or deficiency, with particular emphasis placed on prolactin-secreting pituitary adenomas and co-secreting tumors. Concluding chapters address prolactin-secreting pituitary adenomas in special populations - women in the preconception period or during pregnancy, children and adolescents, and men - as well as plurihormonal and aggressive adenomas and carcinomas. Written and edited by experts in the field, Prolactin Disorders will be a ready reference for a diverse array of professionals, from basic scientists to clinical investigators and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology and neuro-oncology.
The book highlights intricate predisposing factors for pathogenesis of nutritional anemia. It delivers valuable information related to this public health hazard influencing the nutritional health of preschool children. The book is valuable for readers in diverse fields to gain insight of the concept of nutritional anemia in preschool children. Additionally, book furnishes clinical and laboratory methods in a comparative way to assess nutritional anemia. Impact of the disorder on health of preschool children has been covered in a simple language. The book mentions need for interventional strategies for the management of nutritional anemia. Infants, preschool children and women during pregnancy and lactation are highly susceptible to dietary deficiency of iron, folic acid and cyanocobalamin leading to comparatively, higher predisposition to development of nutritional anemia. The condition has myriad of ill effects on nutritional health of preschool children.
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