Whether you are following a problem-based, an integrated or a more traditional medical course, clinical biochemistry is often viewed as one of the more challenging subjects to grasp. What you need is a single resource that not only explains the biochemical underpinnings of metabolic medicine, but also integrates laboratory findings with clinical practice. You will find all this, and more, in the eighth edition of Clinical Biochemistry and Metabolic Medicine. This well-respected text provides comprehensive and measured guidance to this complex area, reflecting the ongoing changes in our understanding of clinical biochemistry while preserving the acknowledged strenghths of previous editions: readability, a firm basis in the underlying science and a clear focus on clinical applicability.

The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.

Although introduction of amino acid chelates in mineral nutrition initially met considerable skepticism and controversy, the greater absorption and bioavailability of amino acid chelated minerals compared to nonchelated minerals have been well-documented for decades. Amino Acid Chelation in Human and Animal Nutrition compiles published chemical, nutritional, and clinical studies with new unpublished research. It interprets the combined data for the first time to explain why the body responds to an amino acid chelate differently than it does to inorganic metal salts. Focusing on digestion, the book follows how chelates are absorbed from the stomach and intestines into the mucosal tissue, their movement from the mucosal tissue into the blood, and uptake into tissue and organ cells. Amino Acid Chelation in Human and Animal Nutrition compares amino acid chelate absorption and metabolism and that of inorganic salts of the same minerals. This book mainly focuses on the ingestion of amino acid metal chelates as a way to optimize mineral absorption, but it also provides a fundamental discussion of chelation chemistry. The author includes his own results, as well as alternate interpretations of the results of numerous studies of animal and human amino acid mineral chelate digestion and absorption. The views published in this book are solely the author's views and do not reflect the views of his company, Albion Laboratories.

This is an optimistic and empowering approach to the daunting task of teaching diabetes patients to care for themselves. Written by a highly respected diabetes educator who has suffered with diabetes for 25 years, the guide provides the clinical and personal expertise that will help nurses and other health professionals to successfully teach diabetes self-management and compliance to adults, children, adolescents, and parents.

The book contains a vast reservoir of information ranging from a thorough overview of diabetes and the physical and emotional toll of living with the disease to number of teaching and motivating strategies that health care professionals can use to create individualized approaches to teaching self-management skills. The guide provides up-to-date information on drug therapies, nutrition management, exercise, chronic complications, glycemic control, diabetes in children, adolescents, and adults, diabetes in adults with special needs or mental illness, and diabetes noncompliance. Addressing the most important and current topics necessary for successful self-regulation and maintenance of diabetes, this innovative desk reference provides a quick guide and instructional tool for nurses and other health professionals who interact with diabetics. This new edition provides:

Clinical guidance and expertise to successfully teach diabetes self-management to adults, adolescents, and children The clinical expertise of a leading diabetes educator and the hard-earned personal wisdom of an author who has suffered with diabetes for 25 years A new chapter on chronic complications that describes a multitude of helpful new treatments A greatly expanded section on nutrition and exercise Thoroughly updated chapters A "must read" chapter on noncompliance, including why this occurs and how to prevent it

In the historical record there is abundant evidence that obesity was a medical and health concern as long as medicine has been practiced. The idea of diet and exercise are bulwarks in the fight against obesity in history from the time of Hippocrates to the 16th century--a span of 2,000 years. However, our scientific understanding of this problem is only a little over 200 years old. An examination of the root cause of what many consider the obesity epidemic, A Guide to Obesity and the Metabolic Syndrome traces the origins and types of obesity and its treatment. Examining in detail the developing treatment for obesity, this book provides: * A history of obesity, including treatment, proposed causes, and perceptions * An examination of the causes and problems associated with obesity * A discussion of lifestyle, diet, exercise, and treatment strategies * A detailed look at the medications and surgeries available for obesity The fact that we have an epidemic of obesity today that is covering the globe suggests that the strategically simple ideas of eating less and exercising more, ideas that require commitment and personal involvement by the individual, have not been very successful. As we move forward in trying to understand this problem, we need to be alert to strategies and tactics that may not require individual motivation and commitment--history has shown that they do not work well. This book supplies guidance on developing and designing novel strategic interventions against obesity and metabolic disorders.

Readers who suffere from low thyroid, or think they might, can find the missing answers. For the person who's been told it's not your thyroid, without then being told convincingly what the problem is. This book provides readers with the knowledge needed to communicate and work with their docteors to get the treatment they deserve.

This User's Guide describes the nature of thyroid disorders, natural thyroid-replacement hormones, and the important role of supplemental vitamins and minerals for thyroid function.

A Yale-trained, board-certified family physician with a specialty in women's health and obstetrics delivers a proven 28-day program to heal the overwhelmed, overloaded systems, and prevent and reverse the myriad of symptoms affecting the vast majority of women today. Weight gain, fatigue, brain fog, hormonal imbalances, and autoimmune conditions-for years, health practitioners have commonly viewed each as individual health problems resulting from a patient's genetic bad luck, poor lifestyle choices, or lack of willpower. Patients, too, have turned to different doctors to alleviate their specific symptoms: an endocrinologist for a thyroid problem; a gynecologist for hormonal issues; an internist for weight, diabetes, and high blood pressure; a rheumatologist for joint problems, and even to therapists or psychologists. While these ailments may seem unrelated, Dr. Aviva Romm contends that they are intrinsically connected by what she calls Survival Overdrive Syndrome, a condition that occurs when the body becomes overloaded. SOS can result from childhood survival patterns or adult life stressors that are compounded by foods we eat, toxins in our environment, viral infections, lack of sleep, disrupted gut microflora, and even prescribed medications. Two of the systems most affected are the adrenal system and the thyroid, which control mood, hormones, inflammation, immunity, energy, weight, will power, blood sugar balance, cholesterol, sleep, and a host of other bodily functions. When these systems become overwhelmed they lead to symptoms that can develop into full blow illnesses, including diabetes, hypertension, osteoporosis, and heart disease-all of which have medically provable origins in SOS. The Adrenal Thyroid Revolution explains SOS, how it impacts our bodies and can lead to illness, and most importantly, offers a drug-free cure developed through Dr. Romm's research and clinical work with tens of thousands of patients. In as little as two weeks, you can lose excess weight, discover increased energy, improve sleep, and feel better. With The Adrenal Thyroid Revolution, you can rescue your metabolism, hormones, mind and mood-and achieve long-lasting health.

The number of elderly patients with diabetes is increasing at a significant rate. Responding to this growth, this source serves as a solid arsenal of information on the varying presentations and challenges associated with diabetes in the geriatric patient, and supplies clearly written sections on the screening, diagnosis, and treatment of diabetes in elderly populations. With contributions from renowned authorities from the national and international institutions, this reference will depict the role of specific co-morbidities, socioeconomic aspects, and caregiver issues on the effective management of diabetes in the older adult.

While nutrition is central to the management of diabetes, there is no one "diabetic diet". Nutritional prescriptions depend on the type of diabetes, food preferences, lifestyle, treatment regimen, comorbidities, state of health, and the route of caloric administration. Nutritional Strategies for the Diabetic/Prediabetic Patient is a comprehensive reference aimed at advancing physicians' knowledge of nutrition in relation to diabetes, allowing them to provide evidence-based recommendations for their diabetic patients. It also provides dietitians and diabetic educators with an in-depth understanding of the pathophysiology and medical treatment of diabetes. Written by scientists, clinicians, registered dietitians, and certified diabetes educators, this book reviews the molecular mechanisms of disease and drug therapy. It also provides recommendations for management with the level of evidence indicated where appropriate. In areas where little research data is available, the editors present recommendations based on extensive clinical experience. The book places particular focus on the synchronization of nutrient intake with medications, and provides unique clinical management tools, along with details of their ability to be replicated for patient use. To facilitate accessibility, it features evidence-based technical reviews of clinical literature and includes numerous tables and figures, with color photos of wound healing stages. Addressing all aspects of nutrition in adult diabetic and prediabetic patients, Nutritional Strategies for the Diabetic/Prediabetic Patient is an important referencefor those concerned with the dietary management of this disease.

Employing a uniform, easy-to-use format, Vitamin Analysis for the Health and Food Sciences, Second Edition provides the most current information on the methods of vitamin analysis applicable to foods, supplements, and pharmaceuticals. Highlighting the rapid advancement of vitamin assay methodology, this edition emphasizes the use of improved and sophisticated instrumentation including the recent applications and impact of the widely adopted LC-MS. Designed as a bench reference, this volume gives you the tools to make efficient and correct decisions regarding the appropriate analytical approach--saving time and effort in the lab.

Each chapter is devoted to a particular vitamin and begins with a brief review of its uniqueness and its role in metabolism. The authors stress a thorough understanding of the chemistry of each compound in order to effectively analyze it and to this end provide the chemical structure and nomenclature of each vitamin, along with tabular information on spectral properties. They supply extensive insight into practical problem-solving including an awareness of the stability of vitamins and their extraction from different biological matrices. All information is heavily documented with the latest scientific papers and organized into easily read tables covering topics necessary for accurate analytical results.

After presenting the chemistry and biochemistry of the vitamin, each chapter details the commonly used analytical and regulatory methods. A summary table gives at-a-glance information on many of these sources, as well as several of the AOAC International Methods. In addition the authors apply their extensive experience in the field to create a critical, interpretive review of the advanced methods of vitamin analysis with sufficient detail to be a valuable guide to cutting-edge methodology.

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules.
Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends.
Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.

That a relation exists between lipids/lipoproteins and coronary artery disease is no longer an arguable point. However, the complexities associated with this relationship, and the number of factors that can impact and alter circumstances and clinical status, are many and diverse. Consequently, this relationship continues to receive a great deal of focus from researchers. Lipid Metabolism and Health, in presenting the latest statement from those positioned on the cutting edge in this arena, provides an overview and historical perspective of the evolution of serum lipids and lipoproteins. It traces their development from a mere curiosity to their acceptance as an established and major coronary artery disease (CAD) risk factor, and, ultimately, to their becoming the subject of clinical guidelines. Considerable attention is focused on the fundamentals, beginning with a chapter on basic lipidology, and progresses through such topics as lipid/lipoprotein metabolism, and the biology of atherosclerosis. Additional topics include methodologies for measuring lipoproteins, clinical strategies used to manage unhealthy lipid levels, and discussion of important influential factors such as obesity, diabetes and metabolic syndrome, diet/nutrition, exercise, cigarette smoking and environmental tobacco smoke, and age, as well as gender, race, and other heredity factors. Qualified and recognized experts in their specific fields of study were recruited by the editors to contribute chapters. They include top researchers in, nutrition, pharmacology, exercise science, and several areas of clinical medicine including cardiology, kinesiology, and immunology. Lipid Metabolism and Health provides a usefulscientific and educational tool for researchers, clinicians, academicians, and students seeking a timely and bona fide source of information on the relationship between lipids and health.

This comprehensive volume completes Frederic Holmes's notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs's research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs's formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known-the formulation of the citric acid cycle. Holmes portrays Krebs's activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes's fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.

Contains new and expanded material on antioxidants in beverages and herbal products, nitric oxide and selenium, and the effect of vitamin C on cardiovascular disease and of lipoic acid on aging, hyperglycemia, and insulin resistance!
Offering over 4200 contemporary references-2000 more than the previous edition-the Second Edition of the Handbook of Antioxidants is an up-to-the-minute source for nutritionists and dietitians, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and medical students in these disciplines.

Contents:
1. The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future 2. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism 3. Sample Preparation 4. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis 5. Quantitative Mass Spectronomy 6. Immunoassay in Bioanalysis 7. Phase I Metabolism 8. Phase II Enzymes 9. In vitro Techniques for Investigating Metabolism 10. Drug to Drug Interactions: an in vitro Approach 11. Clinical Impact of Drug Interactions 12. PreClinical Pharmacokinetics 13. Pharmacokinetic / Pharmacodynamic Modelling in PreClinical Drug Discovery 14. Toxicokinetics 15. Protein Binding in PlasmaA Case History of a Highly Protein Bound Drug 16. Metabolite Identification by Spectroscopy 17. Whole Body Autoradiography 18. Radiolabelled Studies in Man 19. Molecular Biology

This book focuses on predictive, preventative and personalized medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent proof-of-principles for the personalisation of healthcare systems on a global scale. These chapters look at national plans on rare diseases, at biobanking, gene identification in rare diseases, mitochondrial diseases, rare cancers and virus gene therapy, amongst other topics. There is a chapter dedicated to personalized medicine for hereditary deafness and another exploring the complexity of genotype-phenotype correlations. Specific diseases such as Fabry's, Gauchers and mitochondrial cytopathies are highlighted and we look at enzyme replacement therapy in lysosomal storage diseases. This work is part of a series, produced with the involvement of the European Association for Predictive, Preventive and Personalised Medicine. The series focusses on the concept of an integrative medical approach by PPPM. This volume is dedicated to all aspects related to the prediction, prevention and personalised treatments of rare diseases, and in doing so it explores developments relevant to all medical branches. The authors cover ethical considerations, the creation of a robust platform for professional communication, synergies with patient organisations, doctor-patient collaboration and a new philosophy of integrative medicine by PPPM. This volume serves as a reference source for scientific and medical centres in the field and can be used both at medical curricula and graduate level in the life sciences. Those who place a special emphasis on healthcare promotion and innovations intended to combat rare diseases, save the affected lives and enhance life quality will all find this book of great value."

The Diabetes LIFEMAP changes the way chronic diabetes care is delivered forever. The LIFEMAP raises diabetes care for the primary care and ancillary healthcare provider to the level of world renown diabetes expert, David Bleich, MD. For patients, the LIFEMAP provides real-time diabetes care that changes a "tough-to-manage" disease into a shared, personal, and efficient management experience. The LIFEMAP can be used as a stand-alone diabetes management tool or can be combined with our cloud based LIFEMAP platform through GoMo Health. Now care can be delivered seamlessly at home for both provider and patient. The Diabetes LIFEMAP is the playbook for 21st century diabetes care. It starts with an understanding of the basic principles of insulin secretion and moves to a discussion of how the LIFEMAP evolved and why it is such a powerful management tool. Finally, case studies are provided to reinforce basic concepts of LIFEMAP diabetes care with real world examples. Taken together, The Diabetes LIFEMAP succeeds in helping healthcare providers overcome a difficult to manage disease and provides patients with an optimal diabetes outcome with the least amount of effort necessary to achieve high level results.

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts

Containing all the new as well as classical methodologies used in the investigation of amino acid and protein metabolism in human and animal models, this book is needed because of the dramatic increase in research in this field. There is no other book currently on the market that covers these methods of investigation.
Methods for Investigation of Amino Acid and Protein Metabolism explores areas such as amino acid transfer across tissue membranes, past and new applications using stable isotopes, protein synthesis in organs and tissues, and more. Because of the importance of research methods in the field of amino acid and protein nutrition and metabolism, this book facilitates the reader's integration of the concepts involved in these investigative research methods and their corollaries.
In addition to helping any nutrition investigator design and conduct appropriate research protocols in this area of nutrition, this book assists students who are planning to investigate amino acid and protein metabolism in humans or laboratory animals.

The Handbook of Lipids in Human Nutrition is a concise reference for professionals and students interested in the role of lipids in nutrition. Over 100 tables and illustrations provide quick access to the most current data available.

This book discusses, in relatively simple language, the importance of even minute amounts of certain trace elements for the protection of human health and how insufficiency or excess may produce serious diseases. It also examines the use of metal chelators in the treatment of such diseases. Trace Element Medicine and Chelation Therapy looks at the role of metal ions in the evolution and development of living systems and reviews the elemental composition of the human body, the essential biochemistry of metal ions, metal complexes, and the concepts of chemical speciation, as well as the interactions of metals with chelating agents, ligands and drugs. The problems of delivering adequate amounts of trace elements to the human body and the roles of metal containing drugs are also discussed, while the role of chelating agents in the treatment of both spontaneous and accidental overload and the dietary and environmental aspects of such treatment are both comprehensively reviewed. Trace Element Medicine and Chelation Therapy will assist chemists in understanding more about these metal ions and the influences of industrialization and pollution, and will illuminate physicians involved in administering chelation therapy. It illustrates the interdisciplinary nature of the subject and will be of immense interest to students and researchers in chemistry, biochemistry, nutrition and food science, environmental sciences, pharmacology and medicine, as well as to school science teachers and scientifically oriented members of the public.

This book provides a comprehensive review of our knowledge of vitamin B-6 requirements and metabolism throughout pregnancy and lactation. It concentrates on two primary points: adequacy of available methodologies and a presentation of the extant knowledge on vitamin B-6 metabolism and requirements in pregnancy, infancy, lactation, and in women of childbearing age. Many of the chapters offer new perspectives on how decisions have been and are being made with regard to the establishment of dietary recommendations about vitamin B-6 and the adequacy of research to support these decisions.

This book is intended as a source of information for the many scientists who now enter the growing research field of vitamin A in health and disease, reviewing the epidemiological aspects related to vitamin A.

The rapid development and the growing penetration of information and communication technologies (ICT) provide tremendous opportunities for a wide and cost effective application of the ideas of participative democracy and public participation in government decision and policy making. ICT can drive dramatic transformations in the quantity and quality of communication and interaction of government organizations with citizens, revitalizing and strengthening the modern representative democracy which currently faces big problems of reduced citizens' trust and involvement. This book deals with the application of these e-participation ideas in the special and 'difficult', and at the same time highly interesting, national context of Southern Europe and the Balkans. The first chapter provides an overview of e-participation concepts and practices whilst the following chapters analyse pilot applications of e-participation concepts in eight different Southern European and Balkan countries (Spain, France, Italy, Slovenia, Serbia, Albania, Greece, Yugoslav Republic of Macedonia (FYROM)). They cover both the 'classical' e-participation paradigm, based on official e-participation spaces created, operated and controlled by government organizations as well as emerging new e-participation paradigms including e-participation based on web 2.0 social media, and 'scientific-level' e-participation, based on opening government data to the scientific community. This book was originally published as a special issue of the Journal of Balkan and Near Eastern Studies.