This book provides a comprehensive review of our knowledge of vitamin B-6 requirements and metabolism throughout pregnancy and lactation. It concentrates on two primary points: adequacy of available methodologies and a presentation of the extant knowledge on vitamin B-6 metabolism and requirements in pregnancy, infancy, lactation, and in women of childbearing age. Many of the chapters offer new perspectives on how decisions have been and are being made with regard to the establishment of dietary recommendations about vitamin B-6 and the adequacy of research to support these decisions.

This book is intended as a source of information for the many scientists who now enter the growing research field of vitamin A in health and disease, reviewing the epidemiological aspects related to vitamin A.

Intrauterine development and birth constitute an uninterrupted sequence of events that have a molecular physiologic background. Perinatal Biochemistry presents a comprehensive review of this subject. Specific topics addressed include maternal metabolism during pregnancy, maternal insulin resistance, embryonic and fetal metabolism and fuel consumption, the fetal pancreas, growth factors, brain metabolism, and biochemical adaptations to early extrauterine life. The book will be useful to biochemists and physiologists interested in perinatology; clinicians working in areas related to maternal health, gestational development, and delivery; gynecologists, neonatologists; pediatricians; endocrinologists; and internists.

The first comprehensive overview of an emerging field, Metabolic Medicine and Surgery introduces a new paradigm in patient management that crosses existing subspecialty boundaries. This approach is necessitated by the challenges of treating patients with obesity, metabolic syndrome, cardiovascular disease and prediabetes, as well as those with maldigestion, malabsorption, malnutrition and nutritional deficiencies. This book teaches physicians and surgeons what they need to know about clinical nutrition, metabolism and the metabolic effects of bariatric surgery. It is also applicable to those in primary care, including physicians, residents, medical students, nurses and nurse practitioners, physician assistants and dietitians who are on the front lines of treating patients with obesity, diabetes and cardiovascular disease. The book is presented in four sections: 1. An Overview of Metabolic Medicine and Surgery; 2. Metabolic Syndrome, Insulin Resistance and Obesity; 3. Diseases of Undernutrition and Absorption; 4. A Nutritional Relationship to Neurological Diseases. It contains chapters from world-renowned experts who are widely published in major medical journals. The book also benefits from the contributions of clinicians with extensive experience and perspective in the field, including many who have been witness to its major developments. This book's strength lies in the cross-specialty consensus created by the collaboration of the editors and further developed by their renowned contributors. It demonstrates how medicine, surgery, therapeutics, and nutrition can be combined synergistically to impact patient outcomes. It crystallizes the efforts of a multitude of physicians and scientists trying to control the linked pandemics of obesity, type-2 diabetes and cardiovascular disease. This book helps you develop comprehensive solutions to diseases afflicting vast numbers of patients worldwide.

Explores endogenous lipoprotein particles and their interaction with pharmacological agents. Among the topics are receptor-dependent interactions of lipoproteins with tissues and cell types, their uptake and transport with the vascular endothelium, therapeutic and chemical agents that associate in v

There is a critical need for iron intake during the first period of life. The growing infant requires iron to synthesize hemoglobin and to supply expanding tissues with iron-containing enzymes. A lack of iron will eventually lead to iron deficiency anemia, one of the most common single nutrient deficiencies in the world. Today, detailed information has increased our understanding of iron bioavailability from different dietary sources, uptake mechanisms of iron into the small intestinal mucosa for transport to hepatocytes and erythropoietic cells and subsequent receptor mediated cellular acquisition. Metabolic effects of iron deficiency have also been investigated in several tissues. This comprehensive text integrates recent information and address it from a nutritional perspective. It takes this focus because of the increased knowledge on the interrelationship between iron and other essential nutrients. Specific problems of iron nutriture and oxidant stress in prematurely born infants are also addressed in this informative new text

As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.

The rapid development and the growing penetration of information and communication technologies (ICT) provide tremendous opportunities for a wide and cost effective application of the ideas of participative democracy and public participation in government decision and policy making. ICT can drive dramatic transformations in the quantity and quality of communication and interaction of government organizations with citizens, revitalizing and strengthening the modern representative democracy which currently faces big problems of reduced citizens' trust and involvement. This book deals with the application of these e-participation ideas in the special and 'difficult', and at the same time highly interesting, national context of Southern Europe and the Balkans. The first chapter provides an overview of e-participation concepts and practices whilst the following chapters analyse pilot applications of e-participation concepts in eight different Southern European and Balkan countries (Spain, France, Italy, Slovenia, Serbia, Albania, Greece, Yugoslav Republic of Macedonia (FYROM)). They cover both the 'classical' e-participation paradigm, based on official e-participation spaces created, operated and controlled by government organizations as well as emerging new e-participation paradigms including e-participation based on web 2.0 social media, and 'scientific-level' e-participation, based on opening government data to the scientific community. This book was originally published as a special issue of the Journal of Balkan and Near Eastern Studies.

Carnitine Metabolism and Human Nutrition offers a contemporary and in-depth look at the biological effects of carnitine metabolism and its application to clinical and sports nutrition, based on decades of robust scientific enquiry. It gathers and distills key results of the last 20 years of carnitine research to provide an invaluable reference tool for students, researchers, and clinicians. This book addresses the importance of carnitine in skeletal muscle fuel metabolism, the complexities and importance of muscle carnitine transport, and the metabolic insight that has been gained from experiments manipulating muscle carnitine stores. The authors cover the potential application of carnitine supplementation in specific clinical populations and the role of carnitine as an ergogenic aid for athletes. They also provide a comprehensive mechanistic overview of skeletal muscle insulin resistance, including the role of carnitine shuttle systems in the metabolic abnormalities associated with obesity and the metabolic syndrome. Carnitine Metabolism and Human Nutrition provides you with a comprehensive and up-to-date look at the properties and underlying metabolic biochemistry of carnitine. The book provides contributions from leading international scientists, each a pioneer in their chosen study of carnitine metabolism or its application to human nutrition.

In a major contribution to the study of diabetes, this book is the first to analyze the disease through a syndemic framework. An innovative, mixed-methods study, Emily Mendenhall shows how adverse social conditions, such as poverty and oppressive relationships, disproportionately stress certain populations and expose them to disease clusters. She goes beyond epidemiological research that has linked diabetes and depression, revealing how broad structural inequalities play out in the life histories of individuals, families, and communities, and lead to higher rates of mortality and morbidity. This intimate portrait of syndemic suffering is a model study of chronic disease disparity among the poor in high income countries and will be widely read in public health, medical anthropology, and related fields.

The rapid development and the growing penetration of information and communication technologies (ICT) provide tremendous opportunities for a wide and cost effective application of the ideas of participative democracy and public participation in government decision and policy making. ICT can drive dramatic transformations in the quantity and quality of communication and interaction of government organizations with citizens, revitalizing and strengthening the modern representative democracy which currently faces big problems of reduced citizens' trust and involvement. This book deals with the application of these e-participation ideas in the special and 'difficult', and at the same time highly interesting, national context of Southern Europe and the Balkans. The first chapter provides an overview of e-participation concepts and practices whilst the following chapters analyse pilot applications of e-participation concepts in eight different Southern European and Balkan countries (Spain, France, Italy, Slovenia, Serbia, Albania, Greece, Yugoslav Republic of Macedonia (FYROM)). They cover both the 'classical' e-participation paradigm, based on official e-participation spaces created, operated and controlled by government organizations as well as emerging new e-participation paradigms including e-participation based on web 2.0 social media, and 'scientific-level' e-participation, based on opening government data to the scientific community. This book was originally published as a special issue of the Journal of Balkan and Near Eastern Studies.

Patients with mental and substance use disorders have shown higher rates of morbidity and mortality from medical illnesses than the general population, and physicians are also increasingly aware of adverse effects of psychiatric medications on metabolic and cardiovascular health. In light of these problems, this book addresses an important unmet need of patients with mental disorders -- namely, the lack of integration of general medical care with psychiatric care and the related problem of barriers to collaboration and communication among health care providers. Managing Metabolic Abnormalities in the Psychiatrically Ill is the first book to provide a current review of the relationships among psychiatric illnesses, metabolic abnormalities, and treatment, focusing on how clinicians can tailor care to those doubly-afflicted patients.

The book integrates research findings into practical clinical guidelines that spell out what psychiatrists need to know when their patients with mental illness suffer from -- or are at risk of developing -- obesity, diabetes, cardiovascular disease, or the metabolic syndrome. The contributors address those risks that need to be considered in the overall context of treatment, background risks of medical illnesses associated with specific psychiatric disorders themselves, and the means of applying these data to treatment recommendations, monitoring, and clinical practice. Among the specific topics addressed are: - Potential effects of psychotropics on appetite, body weight, and metabolic parameters in obese patients, and the potential effects of anti-obesity agents on psychotic, manic, and depressive syndromes- Increased risk of type 2 diabetes among individuals with psychotic and mood disorders due to neurobiological changes and behavioral effects associated with these disorders- Greater risk for cardiovascular disease among the mentally ill, stressing the importance of mental health providers understanding cardiovascular risk classification and modification strategies- An association between dysregulation of glucose and lipid metabolism and the related risk of type 2 diabetes during treatment with any of the eight second-generation antipsychotics currently available in the United States- Guidance in choice of medications and appropriate monitoring strategies for hyperlipidemia, along with recognition of which antipsychotics pose the greatest risk and an understanding of the common dyslipidemia patterns seen with their use

Chapters include key clinical concepts, quick-reference tables, and extensive references, and a final chapter provides an assessment tool for evaluating patients' metabolic risk. Together, the chapters in this book constitute an authoritative clinical guide that enables psychiatrists to better integrate the treatment of patients' mental disorders with their metabolic conditions.

Wenn bei einem Kind Diabetes diagnostiziert wird, fragen sich Eltern, wie sie sich der Verantwortung stellen koennen und wie sich der Familienalltag verandern wird. Die Autoren, zwei Kinder- und Jugendarzte und eine Psychologin, geben luckenlos Antwort und helfen Eltern, ihre AEngste abzubauen. Sie begleiten sechs Kinder und Jugendliche mit Diabetes und zeigen, wie das Familienleben mit der Krankheit organisiert werden kann. Mit vielen Tipps und Hinweisen zu allen Fragen, die die Lebensgestaltung und die Zukunft eines Kindes mit Diabetes betreffen.

The much-anticipated new edition of this standard textbook compiles current information on the various integrated areas of endocrinology, physiology, and biology of reproduction in one diverse volume. The text provides a physiological foundation for clinical training and encourages further research by including an extensive listing of references at the end of each chapter. Coverage includes the seven domestic species as well as llamas, alpacas, and vicunas.

Revised and improved, the fifth edition contains:
Cutting-edge information--500rovided by new contributors
A new chapter on South American camelids
Concise text which has been filtered to eliminate redundancy
Upgraded illustrations, including additional color plates and over 100 new figures.

"McDonald's Veterinary Endocrinology and Reproduction" is widely used in veterinary schools throughout the United States and Canada, with the Spanish translation used in Latin America and Spain. This mainstay is an essential part of veterinary and agricultural education.

Endocrine emergencies are often potentially life-threatening and can be easily overlooked in patients with no history of endocrine disease. Endocrine Emergencies is a practical guide to identification and treatment for today's clinicians, offering essential coverage of common and serious emergencies related to endocrine metabolic conditions of the thyroid, parathyroid, pituitary, and adrenal glands. Guides clinicians on how to recognize, diagnose, and treat each condition using up-to-date diagnostic techniques and therapeutics. Provides full-color, state-of-the-art coverage of key topics such as acute thyrotoxicosis and thyroid storm, ocular emergencies in Graves' ophthalmopathy, diabetic ketoacidosis, hypopituitarism, postoperative thyroid surgical emergencies, pheochromocytoma, and much more. Features separate chapters on emergencies related to neuroendocrine tumors, pregnant patients, and pediatric patients. Includes sections on emergency overview, symptoms, diagnosis, and treatment in each chapter. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.