This book brings together the behavioral, physiological, and neuroendocrine regulation of calcium. An understanding of how the brain orchestrates whole-body demands for calcium is introduced. The approach is one in which behavior in addition to physiology serves bodily maintenance. The book links basic and clinical literature surrounding calcium homeostasis, as a wide variety of clinical syndromes are tied to calcium metabolism. Because calcium is so important during life stages particular to women, an emphasis is placed on the relevance of calcium to women's health throughout the book, though not exclusively since calcium is fundamental to both sexes.

This book brings together the behavioral, physiological, and neuroendocrine regulation of calcium. An understanding of how the brain orchestrates whole-body demands for calcium is introduced. The approach is one in which behavior in addition to physiology serves bodily maintenance. The book links basic and clinical literature surrounding calcium homeostasis, as a wide variety of clinical syndromes are tied to calcium metabolism. Because calcium is so important during life stages particular to women, an emphasis is placed on the relevance of calcium to women's health throughout the book, though not exclusively since calcium is fundamental to both sexes.

Metabolic disorder is caused by a gene defect, environmental factors or an unknown aetiology. Altered metabolism caused by these factors affects normal function of various organs including the brain and may lead to abnormal phenotype. Understanding agents of causing these abnormalities is useful to interpret possible targets in these diseases. This book reveals what factors contribute in lysosomal storage diseases, Phenylketonuria and Canavan disease, as they are major emerging diseases in multiethnic populations.

Biometals can be seen in human bodies. It is classified as a trace element, one that human beings require in very small amounts. In this book, transporter and transporter receptor of important biometals in human beings are discussed, as well as important toxic metals, such as Cadmium (Cd) in occupational and environmental toxicology. Present knowledge on interactions between toxic metal cadmium and essential metals Zn, Cu and Mg are displayed. The authors also provide a detailed view of the current understanding of important features concerning the role of copper in plant physiology and metabolism, with recent findings on copper chaperons, Cu transporters and Cu trafficking. The applications, properties and molecular structures of silver and nickel are also discussed in detail. Moreover, the progress to date on the chemistry and biochemistry of pentavalent antimony are summarised. The most recent works being done to improve antimonial chemotherapy are also presented. Other chapters discuss the Fur (ferric uptake regulator) proteins, a superfamily of prokaryotic transcription factors that operate at the primary steps in the hierarchy of stress responses. The current knowledge on the complex regulation of Fur proteins in cyanobacteria are also summarized. Additional chapters review various quantitation methods for phytochelatins, analyse the complete complement of metal transporters from various Helicobacter species and discuss the preparation of novel pharmaceuticals to fight infections causing more than 20% of overall number of lethal outcomes.

The Diabetes LIFEMAP changes the way chronic diabetes care is delivered forever. The LIFEMAP raises diabetes care for the primary care and ancillary healthcare provider to the level of world renown diabetes expert, David Bleich, MD. For patients, the LIFEMAP provides real-time diabetes care that changes a "tough-to-manage" disease into a shared, personal, and efficient management experience. The LIFEMAP can be used as a stand-alone diabetes management tool or can be combined with our cloud based LIFEMAP platform through GoMo Health. Now care can be delivered seamlessly at home for both provider and patient. The Diabetes LIFEMAP is the playbook for 21st century diabetes care. It starts with an understanding of the basic principles of insulin secretion and moves to a discussion of how the LIFEMAP evolved and why it is such a powerful management tool. Finally, case studies are provided to reinforce basic concepts of LIFEMAP diabetes care with real world examples. Taken together, The Diabetes LIFEMAP succeeds in helping healthcare providers overcome a difficult to manage disease and provides patients with an optimal diabetes outcome with the least amount of effort necessary to achieve high level results.

Vitamin D is a fat-soluble steroid hormone precursor that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Strictly speaking, it is not a vitamin since human skin can manufacture it, but it is referred to as one for historical reasons. It is often known as calciferol. The major biologic function of vitamin D is to maintain normal blood levels of calcium and phophorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralisation in concert with a number of other vitamins, minerals and hormones. Without vitamin D, bones can become thin, brittle, soft or misshapen. Vitamin D prevents rickets in children and osteomalacia in adults -- skeletal diseases that result in defects that weaken bones. This book gathers international research on the leading-edge of the scientific front.

In biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body's own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antioxidants decrease the damage done to cells by reducing oxidants before they can damage the cell. Virtually all studies of mammals have concluded that a restricted calorie diet extends the life-span of mammals by as much as 100%. This remarkable finding suggests that food is actually more damaging than smoking. As food produces free radicals (oxidants) when metabolised, antioxidant-rich diets are thought to stave off the effects of aging significantly better than diets lacking in antioxidants. The reduced levels of free radicals, resulting from a reduction in their production by metabolism, is thought to be a major cause of the success of caloric restriction in increasing life span. Antioxidants consist of a group of vitamins including vitamin C, vitamin E, selenium and carotenoids, (such as beta-carotene, lycopene, and lutein). This new book brings together the latest research in this dynamic field.

In just under three decades, the world has witnessed an enormous rise in obesity with a parallel growth in cardiometabolic disease risk factors characterized by insulin resistance, dyslipidemia, and hypertension, together known as the metabolic syndrome - conditions previously unheard of in children and adolescents. During this time, we have little knowledge of the global and cumulative detrimental health effects of childhood obesity. As obese children age, not only will their health be negatively affected, but infertility and pregnancy complications associated with the metabolic syndrome will affect generations to come. The work force will undoubtedly be affected because of increased sick days and decreased work productivity. Identifying children and adolescents at the earliest stages of chronic disease onset should be the goal of clinical practice, yet there is no clear guidance for defining the risk of metabolic syndrome or appropriate risk-factor thresholds in these groups. If children are identified early in the disease process, lifestyle and clinical interventions can be instituted when they are potentially more effective. Pediatric Metabolic Syndrome: Comprehensive Clinical Review and Related Health Issues approaches the pediatric metabolic syndrome by elucidating its effects on specific organ systems and by considering the problem through understanding the social, psychological and economic consequences of it. The Editors have recruited an invited group of esteemed experts in the field to provide the most timely and informative approaches on how to deal with this health crisis. Through educating our practitioners, our future researchers, our health and community organizations, our legislators and our families and children, we have the best chance at improving the health trajectory of the next generation.

This book is dedicated to an update on metabolic disorders and their consequences on the developing nervous system. In the last ten years, major scientific advances in biochemical diagnosis have enabled the identification of many new disease entities, as well as a better classification of clinical symptoms and their correlation to biochemical defects. This volume provides an introduction to basic sciences specifically relevant to this disease group, then focuses on each subgroup in turn: hyperphenylalaninaemias, mitochondrial encephalomyopathies, organic acidoses, urea cycle defects, lysosomal storage and peroxylsomal disorders. Finally, a discussion of long term follow-up and family related issues also reports the results of a four-year research project led by the Mariani Foundation.

Wenn bei einem Kind Diabetes diagnostiziert wird, fragen sich Eltern, wie sie sich der Verantwortung stellen koennen und wie sich der Familienalltag verandern wird. Die Autoren, zwei Kinder- und Jugendarzte und eine Psychologin, geben luckenlos Antwort und helfen Eltern, ihre AEngste abzubauen. Sie begleiten sechs Kinder und Jugendliche mit Diabetes und zeigen, wie das Familienleben mit der Krankheit organisiert werden kann. Mit vielen Tipps und Hinweisen zu allen Fragen, die die Lebensgestaltung und die Zukunft eines Kindes mit Diabetes betreffen.

Selected as a Doody's Core Title for 2022! Ideal for all health care professionals who evaluate, diagnose, treat, or refer patients with endocrine disease or disorders, Manual of Endocrinology and Metabolism, Fifth Edition , brings together nearly 150 global authorities who share their knowledge and expertise on endocrine disorders in children, adolescents, and adults. Using a concise outline format, this thoroughly updated manual presents clinical information and protocols needed in everyday practice, with an emphasis on diagnosis and treatment. Succinct chapters and an abundance of tables and diagrams make complex information easy to find and understand. Includes coverage of fundamental understandings and treatment modalities as well as recent therapies, new methods of treatment, new understandings of endocrine physiology, and new surgical approaches to disease states Covers evaluation, pathophysiology, management, and treatment at every age of life, along with short- and long-term goals of reversibility and prevention New chapters include transgender medicine, flushing and sweating, nasal administration of hormones, the growth plate, as well as traumatic brain injury and hypopituitarism New topics include galactorrhea; preoperative, intraoperative, and postoperative management following pituitary surgery; growth hormone in adults, polycystic ovary syndrome, hypercalcemic crisis, parathyroid hormone-related protein, congenital hyperinsulinism, and hypokalemic periodic and non-periodic paralysis New and expanded coverage of diabetes mellitus includes hypoglycemia-associated autonomic failure, glucocorticoid-induced hyperglycemia, C-peptide, cystic fibrosis-related diabetes, the artificial pancreas, glycated proteins, inhaled insulin, and the application of stem cells in diabetes mellitus Serves as an excellent resource for board preparation, as well as a concise daily reference for endocrinologists, general practitioners, internists, pediatricians, physician assistants, nurse practitioners, and others who see patients with primary or underlying endocrine disease Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s ), such as computer, tablet, or smartphone Easily convert to audiobook , powering your content with natural language text-to-speech Adapt for unique reading needs , supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

Nutritional Biochemistry takes a scientific approach to nutrition. It covers not just "whats"--nutritional requirements--but why they are required for human health, by describing their function at the cellular and molecular level. Each case study either leads to a subsequent discovery or enables an understanding of the physiological mechanisms of action of various nutrition-related processes. The text is "picture-oriented" and the commentary is directed towards explaining graphs, figures, and tables.
Nutritional Biochemistry includes a discussion of relevant aspects of physiology, food chemistry, toxicology, pediatrics, and public health. Experimental techniques for nutritional science are emphasized, and primary data is included to help give students a feel for the nutrition literature. This "real-world" approach provides students with a realistic view of the basis for much of our understanding of nutritional biochemistry.
* Integrates biochemistry and nutrition in a case-oriented method
* Emphasizes a hands-on approach to learning - case histories and clinical and research data illustrate all major points
* Places emphasis on metabolism - metabolic pathways, enzymology, nutrient requirements (including RDA values)
* Reveals the benefits of the Mediterranean diet, the biochemistry of exercise, the cell signaling pathways, how nutrition can influence the development of cancer, and the anthropometry and genetics of obesity.

Frank Nawroth thematisiert das Social Freezing und die zugehoerige Beratung, die nicht nur Chancen, sondern auch denkbare Komplikationen und Grenzen der Methode aufzeigen muss. Zum Beispiel haben die gesellschaftspolitisch nicht optimal geloeste Problematik des moeglichen Karriere-Nachteils einer berufstatigen Mutter oder die haufig bestehende Schwierigkeit, den geeigneten Partner zu finden, bei gleichzeitig verbesserten Kryokonservierungsmethoden dazu gefuhrt, dass Frauen ohne medizinische Indikation uber das Einfrieren ihrer Eizellen nachdenken. Die Technologie selbst ist seit Langerem Routine vor fertilitatsbeeintrachtigenden Therapien onkologischer Erkrankungen (Operation, Strahlen- und/oder Chemotherapie) im reproduktiven Alter.

Das Standardwerk zur arteriellen Hypertonie, das keine noch so knifflige Frage auslasst! Die Klinik aller Hypertonieformen, die zeitgemasse Diagnostik und alle etablierten und neuen Therapieansatze sind von den jeweiligen Top-Spezialisten beschrieben. Ein besonderer Schwerpunkt liegt auf dem Umgang mit speziellen therapeutischen Problemen. Kein Arzt in Praxis und Klinik, der Patienten mit arterieller Hypertonie betreut, kann auf dieses Buch verzichten. Von der Hochdruckliga wird das Buch empfohlen.

Unter Mitarbeit zahlreicher Fachwissenschaftler

Why Do I Still Have Thyroid Symptoms? was written to address the true causes of hypothyroidism in this country and how to manage them. The vast majority of hypothyroid cases are caused by Hashimoto's disease, an autoimmune reaction, and are being treated inappropriately or misdiagnosed by the standard health care model. Through exhaustive research and clinical experience, Dr. Kharrazian has discovered the many causes of hypothyroidism, including autoimmunity, and how to manage it. NOTE: This is the same thyroid book but under a new publisher. To read reviews of the book, please visit the old listing at http: //www.amazon.com/Still-Thyroid-Symptoms-Tests-Normal/dp/1600376703/ref=sr_1_1?ie=UTF8&qid=1348258676&sr=8-1&keywords=kharrazian.

Diabetes in Medizin- und Kulturgeschichte behandelt die Geschichte der wissenschaftlichen Erforschung dieses Leidens von der Antike bis zur Entdeckung des Insulins (1921) unter gleichzeitiger Berucksichtigung der Geschichte des Patienten und kulturhistorischer Hintergrunde. Die abgedruckten medizinhistorischen Studien eroertern sowohl allgemeine Zusammenhange wie spezifische Details und besondere Forschungsleistungen der Vergangenheit. In der Bibliographie der Quellen werden die wesentlichen historischen Beitrage der Diabetesforschung und Diabetestherapie mit den Autoren und der Angabe der Druckorte zusammengestellt. Die Bibliographie der Sekundarliteratur vereinigt internationale Studien seit dem vergangenen Jahrhundert bis in die jungste Gegenwart uber die Geschichte der Theorien des Diabetes und der therapeutischen Ansatze. Abbildungen und literarische Texte dokumentieren kulturhistorische Zusammenhange. Ein Personen- und Sachregister erleichtert die Benutzung dieses Bandes, der insgesamt Mediziner, Medizinhistoriker, Medizinstudenten, Allgemeinhistoriker wie auch Diabetespatienten anregen moechte.

H. E. Schaefer Pathologisches Institut, Universitat Freiburg Dieser Band berichtet uber die 6. Arbeitstagung der Deutschen Gesellschaft fur Arterioskleroseforschung, die vom 5. bis 7. April 1992 am nun schon gewohnten Tagungsort, im Heinrich Fabri-Institut in Blaubeuren, stattgefunden hat. Dieses Haus bietet die Moglichkeit, am gleichen Ort zu tagen und zu wohnen, und garantiert insofern ideale Rahmenbedingungen fur einen intensiven Gedanken austausch. In einer besonderen Feierstunde dankte die Gesellschaft dem Prasidenten der Universitat Tubingen, Herrn Dr. A. Theis, fur das bereits mehrjahrig genossene Gastrecht, insbesondere aber auch ihrem Sponsor der ersten Stunde, Herrn Ehrensenator Adolf Merckle, Inhaber der Firma Merckle GmbH - Chemisch-Pharmazeutische Fabrik/Blaubeuren, fur die grosszugige Finanzierung dieser Tagung. Einen besonderen Akzent erfuhr diese Tagung durch die erstmalige Verleihung des W. H. Hauss-Preises an Herrn Dr. H. A. Lehr vom Institut fur Chirurgische Experimentalforschung der Ludwig-Maximilians-Universitat Munchen fur seine Arbeit "Superoxide-dependent stimulation of leukocyte adhesion by oxidatively modified low density lipoprotein in vivo." Uber Inhalt und Bedeutung dieser Forschungen zur Thematik der Stimulation von Leukozyten durch oxidativ modifizierte LDL kann sich der Leser durch einen weiterfuhrenden Beitrag der Arbeitsgruppe um Herrn Dr. Lehr in diesem Tagungsband informieren. Je ein Preis fur den besten Vortrag sowie fur das beste Poster der Tagung wurden an die Autoren Dr. M. Thie (Munster) und D. Axel (Tubingen) verliehen. Diese neu eingerichteten Preise sind dankenswerter Weise von der Firma Lichtwer Pharma GmbHlBerlin gestiftet worden."

In diesem Praxisbuch finden Sie alle notwendigen Informationen, um Ihre Diabetespatienten kompetent rundum zu betreuen - von der Entscheidung fur die optimale Therapieform uber die Vor- und Nachsorge bei Operationen bis zur Behandlung von Spatkomplikationen. Die dritte Auflage wurde fast vollstandig neu verfasst, noch ubersichtlicher gestaltet und zum schnellen Erfassen der Inhalte um zahlreiche Tabellen, Aufzahlungen und UEbersichten erganzt. - Schwerpunkt der Neuauflage: Vorbeugung und Behandlung diabetesassoziierter Spatkomplikationen. ...ein sehr gelungenes Werk, das sicherlich rasch seinen festen Platz in der klinischen Diabetesliteratur finden wird. (Ernahrungs-Umschau)

Ein Screening auf angeborene endokrine und metabole Stoerungen ermoeglicht die Fruherkennung von Krankheiten wie Hypothyreose, AGS (adrenogenitales Syndrom), Phenylketonurie, Galaktosamie, Biotinidasemangel, Cystische Fibrose oder Homocystinurie. Je nach Land und politischen Bestimmungen unterscheiden sich jedoch die routinemassig durchgefuhrten Untersuchungen. Dieses Handbuch beschreibt praxisbezogen die biochemischen Grundlagen, die Grundsatze der Labor- und Bestatigungsdiagnostik sowie Therapiemoeglichkeiten zu insgesamt zwoelf Krankheiten. Daruber hinaus werden praanalytische Fragen, wie Zeitpunkt und Art der Blutentnahme oder moegliche Stoerfaktoren, umfassend behandelt. Der allgemeine Teil geht auf ethische und psychosoziale Aspekte des Screenings ein. Ein Verzeichnis der Screeningzentren und jener Labors, die fur die Bestatigungsdiagnostik Dienste anbieten, sowie ein Adressenverzeichnis von Elterngruppen und Informationsquellen im Internet komplettieren dieses Buch.

Der vorliegende Band fullt eine Lucke. Er gibt einen komprimierten Uberblick uber Chancen und Risiken dieser immer noch mit Vorurteilen belegten Therapieform. Die vorliegenden Langzeitergebnisse belegen die hervorragenden Moglichkeiten der Radiojodtherapie. Der vielbeschaftigte Arzt soll sich durch dieses Praxisbuch rasch mit der speziellen Materie und den deutschen Behandlungsmodalitaten vertraut machen konnen. Das Buch enthalt auch eine komplette Ubersicht der deutschen Therapiezentren, damit die Patienten trotz relativ knapper Kapazitaten moglichst rasch einer Radiojodbehandlung zugefuhrt werden konnen."

Die vergessene Alternative zur aufwendigen Arzneitherapie! In diesem Buch erfahren Sie alles Wissenswerte uber die erfolgreiche Behandlung von Erkrankungen mit Hilfe der Ernahrungstherapie. Die Vorzuge gegenuber der herkoemmlichen Arzneitherapie liegen auf der Hand: Sie ist risikoarm, effizient, kostengunstig und vor allem hat der Patient keinerlei Nebenwirkungen zu befurchten. Dieses Kompendium gibt praxisbezogene Ernahrungstipps zu einem grossen Spektrum von Krankheiten, wie zum Beispiel bei Cholesterinproblemen, koronarer Herzkrankheit, Bluthochdruck, Diabetes mellitus und Krebs. Der Inhalt basiert auf jahrzehntelanger diatetischer Erfahrung grosser Kliniken. Alphabetisch geordnete Stichwoerter bieten dem Arzt, der Diatassistentin und der OEkotrophologin einen schnellen Zugriff auf Informationen zu annahernd 600 Krankheitsbildern aus allen Fachgebieten der Medizin. Jetzt als vollstandig uberarbeitete und erweiterte Neuauflage!

Das Thema Ernahrung kommt angesichts der steigenden Zahl der Erkrankungen und der damit zusammenhangenden Kosten auch in der arztlichen Praxis ein immer grosserer Stellenwert zu. Patienten fragen, der Arzt muss antworten. Dieses Buch ist fur die Praxis der arztlichen Ernahrungsberatung konzipiert. Wissenschaftler und Kliniker stellen klare und konkrete Handlungsanweisungen zusammen, beantworten Fragen kurz und schlussig und verzichten dabei auf theoretische Hintergrunde. Das Buch geht Seite fur Seite auf die verschiedenen ernahrungsabhangigen Krankheiten ein, nennt die wichtigsten Ernahrungsempfehlungen und erlautert die Funktion von Vitaminen und Mineralstoffen. Methodische Fragen der Ernahrungsberatung werden ebenso angesprochen wie (fast) alle Diaten, nach denen Patienten oft fragen.