Der Band behandelt Grundlagen, Diagnostik und Therapie von Lungenerkrankungen. Was ist medizinisch und okonomisch sinnvoll? Wie lasst sich die Kooperation zwischen ambulanter und stationarer Betreuung im Sinne des Patienten optimieren? Welche Werte mussen wie oft kontrolliert werden? Diese und andere Fragen beantwortet das Praxishandbuch knapp, klar und auf dem neuesten Stand von Diagnostik und Therapie. Vorgestellt wird eine individuell abgestimmte Stufentherapie, die Begleiterkrankungen, Alter und Geschlecht des Patienten berucksichtigt."

Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases. The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed. The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer. Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer. Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.

Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students.

The constellation of obesity, hypertension, dyslipidemia, and hyperglycemia within an individual, is referred to as metabolic syndrome (MetS), and is increasing in prevalence in the United States and world-wide. Patients with MetS have a heightened probability of developing type 2 diabetes and atherothromotic disease. In this book, the authors present current research in the study of the classification, risk factors and health impact of metabolic syndrome. Topics include the pathophysiological changes to the vasculature and inflammation within the skeletal muscle that accompany MetS; metabolic syndrome in children; role of triglyceride modifier genetic variants in the development of MetS; subclinical atherosclerosis and risk of stroke in metabolic syndrome; nuclear receptors and MetS; vascular repair by endothelial progenitor cells in an experimental model of metabolic syndrome; chromium mediations of glucose tolerance; and sleep disturbances and glucose variability.

Metabolic disorder is caused by a gene defect, environmental factors or an unknown aetiology. Altered metabolism caused by these factors affects normal function of various organs including the brain and may lead to abnormal phenotype. Understanding agents of causing these abnormalities is useful to interpret possible targets in these diseases. This book reveals what factors contribute in lysosomal storage diseases, Phenylketonuria and Canavan disease, as they are major emerging diseases in multiethnic populations.

The main biological function of lipids include energy storage, as structural components of cell membranes, and as important signalling molecules. Lipids are a major source of energy in the body and supply essential lipid-soluble vitamins and polyunsaturated fatty acids (PUFA) that are required in relatively high amounts during growth and life. Lipids affect the composition of membrane structures and modulate membrane functions as well as the functional development of the central nervous system. This book presents and discusses topical data on lipids including: the lipid composition of erythrocytes in cardiovascular and hepatobiliary disease; the correlation of dietary fat, fat composition and fatty acids on human nutrition; flax lipids; Vitamin E lipids with important antioxidant benefits; omega-3 fatty acids in neurochemistry; and others.

This book reports updated data from the literature on potential drug-drug interactions occurring between drugs used to treat each individual disease of the metabolic syndrome. The manual is focused on metabolic syndrome drugs. Possible drug-drug interactions and their potential mechanisms are summarised and discussed. Chemical characteristics and mechanisms of action of each drug are also briefly described. Some new anti-obesity, anti-diabetes, lipid lowering and anti-hypertensive drugs were also reported and briefly discussed.

Vitamin D is a fat-soluble steroid hormone precursor that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Strictly speaking, it is not a vitamin since human skin can manufacture it, but it is referred to as one for historical reasons. It is often known as calciferol. The major biologic function of vitamin D is to maintain normal blood levels of calcium and phophorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralisation in concert with a number of other vitamins, minerals and hormones. Without vitamin D, bones can become thin, brittle, soft or misshapen. Vitamin D prevents rickets in children and osteomalacia in adults -- skeletal diseases that result in defects that weaken bones. This book gathers international research on the leading-edge of the scientific front.

In biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body's own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antioxidants decrease the damage done to cells by reducing oxidants before they can damage the cell. Virtually all studies of mammals have concluded that a restricted calorie diet extends the life-span of mammals by as much as 100%. This remarkable finding suggests that food is actually more damaging than smoking. As food produces free radicals (oxidants) when metabolised, antioxidant-rich diets are thought to stave off the effects of aging significantly better than diets lacking in antioxidants. The reduced levels of free radicals, resulting from a reduction in their production by metabolism, is thought to be a major cause of the success of caloric restriction in increasing life span. Antioxidants consist of a group of vitamins including vitamin C, vitamin E, selenium and carotenoids, (such as beta-carotene, lycopene, and lutein). This new book brings together the latest research in this dynamic field.

Ein kurzgefasster Leitfaden zu den modernen Therapiestrategien bei Diabetes im Kindes- und Jugendalter. UEbersichtlich und auf dem neuesten Stand - fur alle medizinischen und nicht-medizinischen Profis, die wenig Zeit haben, die wissenschaftlichen Grundlagen bereits kennen und schnelle Orientierung benoetigen.

kurz - prazise - konkret

Diabetes die Volksseuche des 21. Jahrhunderts: Jeder 5. Patient in der Arztpraxis hat Diabetes.

- Diagnostik und Therapie praxisorientiert und kompakt
- Konkrete Therapieziele, neueste Richtwerte und Therapeutika
- Hilfreichen Leitfaden: Notfalle, perioperative/periinterventionelle Versorgung
- Tipps und Tricks vom erfahrenen, interdisziplinaren Diabetes-Team

Gepruft in der taglichen Routine

Nach den Leitlinien der Deutschen Diabetes-Gesellschaft (DDG)"

Enzymes are the astonishing, tiny molecular machines that make life possible. Each one of these small proteins speeds up a single chemical reaction inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that collectively we recognise as life, from making DNA to digesting food. This Very Short Introduction explains the why and the how of speeding up these reactions - catalysis - before going on to reveal how we have evolved these catalysts of such extraordinary power and exquisite selectivity. Paul Engel shows how X-ray crystallography has revealed the complex molecular shapes that allow enzymes to function at an extraordinarily sophisticated level. He also examines medical aspects of enzymes, both in the way faulty enzymes cause disease and in the way enzymes can be used for diagnosis and therapy. Finally, he looks at the many varied ways in which individual enzymes, taken out of their biological context, are used nowadays as tools - in washing powders, food production, waste treatment, and chemical synthesis. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas. Timely and up-to-date, it opens with a review of the historical aspects of prolactin research and a discussion of pituitary anatomy and physiology. Several chapters examine basic and translational aspects of prolactin physiology, focusing on recent developments and future directions. The main portion of the book is comprised of chapters presenting the clinical aspects of prolactin excess or deficiency, with particular emphasis placed on prolactin-secreting pituitary adenomas and co-secreting tumors. Concluding chapters address prolactin-secreting pituitary adenomas in special populations - women in the preconception period or during pregnancy, children and adolescents, and men - as well as plurihormonal and aggressive adenomas and carcinomas. Written and edited by experts in the field, Prolactin Disorders will be a ready reference for a diverse array of professionals, from basic scientists to clinical investigators and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology and neuro-oncology.

This practical book describes only neurometabolic hereditary diseases which have a specific treatment and encourages the general neurologist to think of the most common neurometabolic hereditary diseases, which he might have seen and never considered in the differential diagnosis. Information regarding how to deal with diseases with special therapy is provided (i.e. enzymatic replacement therapy in Fabry disease and Pompe disease), as is information on diseases which are not easily recognized (i.e. Niemann-Pick disease type C), and diseases with clinical features mimicking other common neurodegenrative diseases (i.e. Wilson's disease). Neurometabolic Hereditary Diseases is written with a clinical focus for adult neurologists working in general hospitals.

In just under three decades, the world has witnessed an enormous rise in obesity with a parallel growth in cardiometabolic disease risk factors characterized by insulin resistance, dyslipidemia, and hypertension, together known as the metabolic syndrome - conditions previously unheard of in children and adolescents. During this time, we have little knowledge of the global and cumulative detrimental health effects of childhood obesity. As obese children age, not only will their health be negatively affected, but infertility and pregnancy complications associated with the metabolic syndrome will affect generations to come. The work force will undoubtedly be affected because of increased sick days and decreased work productivity. Identifying children and adolescents at the earliest stages of chronic disease onset should be the goal of clinical practice, yet there is no clear guidance for defining the risk of metabolic syndrome or appropriate risk-factor thresholds in these groups. If children are identified early in the disease process, lifestyle and clinical interventions can be instituted when they are potentially more effective. Pediatric Metabolic Syndrome: Comprehensive Clinical Review and Related Health Issues approaches the pediatric metabolic syndrome by elucidating its effects on specific organ systems and by considering the problem through understanding the social, psychological and economic consequences of it. The Editors have recruited an invited group of esteemed experts in the field to provide the most timely and informative approaches on how to deal with this health crisis. Through educating our practitioners, our future researchers, our health and community organizations, our legislators and our families and children, we have the best chance at improving the health trajectory of the next generation.

There is an epidemic of fatigue running rampant in our society. Every morning, hundreds of thousands of women wake up to find themselves exhausted, overwhelmed, and overstressed. Groggily turning off the alarm, they reach for coffee, soda, or some other promise of energy. They suffer through the day-irritable, on edge, forgetful, depressed, and craving sweets. And then, at night, they have trouble sleeping. Diet and exercise don't seem to change things-if they even have the energy to follow these programs. So what on earth is going on?In "Are You Tired and Wired?, " Marcelle Pick, co-founder of Women to Women-one of the first clinics in the country devoted to providing health care for women by women-and the author of "The Core Balance Diet," focuses on the root cause of these symptoms: adrenal dysfunction.With all the stresses that exist today-from challenges at home and at work to environmental toxins to chronic health problems-the adrenal glands, which are responsible for providing the fight-or-flight hormones, can force the body to endure a constant flood of stress hormones that can ultimately lead to multiple health issues, especially severe fatigue. The good news is that through diet, lifestyle adjustments, and reprogramming of stressful emotional patterns this can all be fixed Pick helps readers identify which of three adrenal dysfunction profiles they fit-racehorse, workhorse, or flatliner-and then lays out an easy-to-follow, scientifically based program to help them restore adrenal balance, re-gear their metabolism, and regain their natural energy to live a happier and less-stressed life.

The focus of this book is the characterisations and hydrolysing mechanism of the non-specific enzymes toward chitosan choosing the three typical non-specific enzymes: cellulase, lipase and papain as objects. The authors studied the enzymatic characteristics, purification, product analysis, glycoside bond cleavage, active sites and gene cloning of these enzymes to expatiate their non-specific hydrolysis mechanism.

The much-anticipated new edition of this standard textbook compiles current information on the various integrated areas of endocrinology, physiology, and biology of reproduction in one diverse volume. The text provides a physiological foundation for clinical training and encourages further research by including an extensive listing of references at the end of each chapter. Coverage includes the seven domestic species as well as llamas, alpacas, and vicunas.

Revised and improved, the fifth edition contains:
Cutting-edge information--500rovided by new contributors
A new chapter on South American camelids
Concise text which has been filtered to eliminate redundancy
Upgraded illustrations, including additional color plates and over 100 new figures.

"McDonald's Veterinary Endocrinology and Reproduction" is widely used in veterinary schools throughout the United States and Canada, with the Spanish translation used in Latin America and Spain. This mainstay is an essential part of veterinary and agricultural education.

Selected as a Doody's Core Title for 2022! Ideal for all health care professionals who evaluate, diagnose, treat, or refer patients with endocrine disease or disorders, Manual of Endocrinology and Metabolism, Fifth Edition , brings together nearly 150 global authorities who share their knowledge and expertise on endocrine disorders in children, adolescents, and adults. Using a concise outline format, this thoroughly updated manual presents clinical information and protocols needed in everyday practice, with an emphasis on diagnosis and treatment. Succinct chapters and an abundance of tables and diagrams make complex information easy to find and understand. Includes coverage of fundamental understandings and treatment modalities as well as recent therapies, new methods of treatment, new understandings of endocrine physiology, and new surgical approaches to disease states Covers evaluation, pathophysiology, management, and treatment at every age of life, along with short- and long-term goals of reversibility and prevention New chapters include transgender medicine, flushing and sweating, nasal administration of hormones, the growth plate, as well as traumatic brain injury and hypopituitarism New topics include galactorrhea; preoperative, intraoperative, and postoperative management following pituitary surgery; growth hormone in adults, polycystic ovary syndrome, hypercalcemic crisis, parathyroid hormone-related protein, congenital hyperinsulinism, and hypokalemic periodic and non-periodic paralysis New and expanded coverage of diabetes mellitus includes hypoglycemia-associated autonomic failure, glucocorticoid-induced hyperglycemia, C-peptide, cystic fibrosis-related diabetes, the artificial pancreas, glycated proteins, inhaled insulin, and the application of stem cells in diabetes mellitus Serves as an excellent resource for board preparation, as well as a concise daily reference for endocrinologists, general practitioners, internists, pediatricians, physician assistants, nurse practitioners, and others who see patients with primary or underlying endocrine disease Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s ), such as computer, tablet, or smartphone Easily convert to audiobook , powering your content with natural language text-to-speech Adapt for unique reading needs , supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.

This book discusses the latest research in the pathophysiology, diagnosis, and screening of diabetes and its management. It reviews novel technologies for early diagnosis and highlights the molecular mechanisms of microvascular and macrovascular complications of diabetes 2 mellitus. The book covers the applications of nanotechnology in diagnostics, monitoring, and treatment of diabetes mellitus. The chapter also presents the latest developments in differentiating pancreatic cells from PSCs and illustrates the challenges of their therapeutic application in treating diabetes. The book also explores the prospective medicinal plants comprising either plant extract or isolated bioactive phytoconstituents bearing anti-diabetic potential, which has been reported in several in vitro, in vivo, or clinical studies. It further examines the major mechanisms involved in cardiovascular complications among type 2 diabetes mellitus individuals and discusses the various pharmacological interventions and agents developed to delay cardiovascular events and thereby the quality and duration of the patients. Towards the end, the book summarizes the potential impact of ketogenic diets on diabetic patients, and the role of genetic vulnerability in diabetic nephropathy. As such, this book is a valuable source for students, researchers, and practitioners working in glucose metabolism, diabetes, and human health.