Ubersichtlich und aktuell fasst dieses Taschenbuch die praktischen Aspekte der Insulinbehandlung zusammen: Fur viele Arzte ist dieses Buch zum wichtigsten Leitfaden der Insulintherapie geworden. Die 4. Auflage wurde vollstandig uberarbeitet. Der Leser kann sicher sein, alle neueren fur die praktischen Belange notwendigen Fakten in diesem Buch zu finden. Bald wird es in der Bundesrepublik ca. eine halbe Million Menschen geben, die Insulin spritzen - von Arzten aller Fachgebiete erwartet der Patient, dass sie mit dieser Therapie vertraut sind. Auch fur Medizinstudenten ist dieses Buch sehr gut geeignet.

Metabolic disorder caused by altered levels of metabolism resulting pathophysiological abnormalities often leads to childhood death. Several new developments on metabolic diseases research have been emerging. Gaucher disease is a lysosomal storage disorder caused by glucocerebrosidase gene mutations resulting glucocerebrosidase deficiency. Current studies show that the same gene mutations also contribute to the Parkinson's disease. Tetrahydrobiopterin (BH4) has been widely used in treating patients with Phenylketonuria over a decade. Recent studies reveal that patients treated with BH4 over one-year period showed reduced levels of serum B12, folate and iron intake and therefore patients under chronic BH4 treatment needed to be advised to have additional micronutrients along with BH4. Macrocephaly was used as one of the important features to diagnose Canavan disease. However, a recent study showing a child with aspartoacylase gene mutation developed microcephaly. Hence, Canavan disease phenotype can be either macrocephaly or microcephaly. These are a few examples of recent developments on metabolic diseases research. Therefore, this book was aimed to compose current developments on metabolic diseases research for the use by broad spectrum of experts including Physicians, Neuroscientists, Neurologists, Biomedical researchers, Biochemists, Molecular biologists, Basic Science Researchers and Medical Students.

The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations. This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas. Winner of the 2021 PROSE Award in Biomedicine from the Association of American Publishers!

This issue of Endocrinology and Metabolism Clinics, Guest Edited by Dr. Vin Tangpricha, will focus on Transgender Medicine. This issue is one of four issues selected per year by the series Consulting Editor, Adriana Ioachimescu. Topics include, but are not limited to, Epidemiology of Transgender, Etiology of Gender Expression and Identity, Hormone therapy in children and adolescents, Transfeminine Hormone Therapy, Transmasculine Hormone Therapy, Dermatologic Conditions in Transgender persons, Gender Affirming Surgery, Fertility Considerations in Transgender persons, Transgender Medicine in the Military, Transgender Medicine in the Elderly, Mental Health in Transgender Persons, Primary Care in Transgender Persons, Cancer Risk in Transgender Persons, Osteoporosis, HIV in Transgender Persons, and Education Needs of Providers of Transgender Populations.

Der Band behandelt Grundlagen, Diagnostik und Therapie von Lungenerkrankungen. Was ist medizinisch und okonomisch sinnvoll? Wie lasst sich die Kooperation zwischen ambulanter und stationarer Betreuung im Sinne des Patienten optimieren? Welche Werte mussen wie oft kontrolliert werden? Diese und andere Fragen beantwortet das Praxishandbuch knapp, klar und auf dem neuesten Stand von Diagnostik und Therapie. Vorgestellt wird eine individuell abgestimmte Stufentherapie, die Begleiterkrankungen, Alter und Geschlecht des Patienten berucksichtigt."

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students.

Wie sahe Marilyn Monroe mit Morbus Basedow aus? An eingangigen Beispielen und Abbildungen erklart der Autor die haufigsten Schilddrusenerkrankungen sowie die modernen Untersuchungs- und Therapie-Verfahren. Die verstandlichen Beschreibungen vermitteln Patienten ein klares Bild der Erkrankung und unterstutzen den Erfolg Ihrer Therapie."

The constellation of obesity, hypertension, dyslipidemia, and hyperglycemia within an individual, is referred to as metabolic syndrome (MetS), and is increasing in prevalence in the United States and world-wide. Patients with MetS have a heightened probability of developing type 2 diabetes and atherothromotic disease. In this book, the authors present current research in the study of the classification, risk factors and health impact of metabolic syndrome. Topics include the pathophysiological changes to the vasculature and inflammation within the skeletal muscle that accompany MetS; metabolic syndrome in children; role of triglyceride modifier genetic variants in the development of MetS; subclinical atherosclerosis and risk of stroke in metabolic syndrome; nuclear receptors and MetS; vascular repair by endothelial progenitor cells in an experimental model of metabolic syndrome; chromium mediations of glucose tolerance; and sleep disturbances and glucose variability.

Metabolic disorder is caused by a gene defect, environmental factors or an unknown aetiology. Altered metabolism caused by these factors affects normal function of various organs including the brain and may lead to abnormal phenotype. Understanding agents of causing these abnormalities is useful to interpret possible targets in these diseases. This book reveals what factors contribute in lysosomal storage diseases, Phenylketonuria and Canavan disease, as they are major emerging diseases in multiethnic populations.

The main biological function of lipids include energy storage, as structural components of cell membranes, and as important signalling molecules. Lipids are a major source of energy in the body and supply essential lipid-soluble vitamins and polyunsaturated fatty acids (PUFA) that are required in relatively high amounts during growth and life. Lipids affect the composition of membrane structures and modulate membrane functions as well as the functional development of the central nervous system. This book presents and discusses topical data on lipids including: the lipid composition of erythrocytes in cardiovascular and hepatobiliary disease; the correlation of dietary fat, fat composition and fatty acids on human nutrition; flax lipids; Vitamin E lipids with important antioxidant benefits; omega-3 fatty acids in neurochemistry; and others.

This book reports updated data from the literature on potential drug-drug interactions occurring between drugs used to treat each individual disease of the metabolic syndrome. The manual is focused on metabolic syndrome drugs. Possible drug-drug interactions and their potential mechanisms are summarised and discussed. Chemical characteristics and mechanisms of action of each drug are also briefly described. Some new anti-obesity, anti-diabetes, lipid lowering and anti-hypertensive drugs were also reported and briefly discussed.

Vitamin D is a fat-soluble steroid hormone precursor that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Strictly speaking, it is not a vitamin since human skin can manufacture it, but it is referred to as one for historical reasons. It is often known as calciferol. The major biologic function of vitamin D is to maintain normal blood levels of calcium and phophorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralisation in concert with a number of other vitamins, minerals and hormones. Without vitamin D, bones can become thin, brittle, soft or misshapen. Vitamin D prevents rickets in children and osteomalacia in adults -- skeletal diseases that result in defects that weaken bones. This book gathers international research on the leading-edge of the scientific front.

In biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body's own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antioxidants decrease the damage done to cells by reducing oxidants before they can damage the cell. Virtually all studies of mammals have concluded that a restricted calorie diet extends the life-span of mammals by as much as 100%. This remarkable finding suggests that food is actually more damaging than smoking. As food produces free radicals (oxidants) when metabolised, antioxidant-rich diets are thought to stave off the effects of aging significantly better than diets lacking in antioxidants. The reduced levels of free radicals, resulting from a reduction in their production by metabolism, is thought to be a major cause of the success of caloric restriction in increasing life span. Antioxidants consist of a group of vitamins including vitamin C, vitamin E, selenium and carotenoids, (such as beta-carotene, lycopene, and lutein). This new book brings together the latest research in this dynamic field.

This volume of the "Annals of the New York Academy of Sciences" covers recent and new developments in all fields of neuroendocrinology, including neuroendocrine control of reproduction, stress, growth and metabolism, and hypothalamic neuropeptidergic systems. Special attention will be paid to the comparative aspects of neuroendocrinology, from invertebrates to mammals including humans. The volume stems from the 7th International Congress of Neuroendocrinology, held by the International Neuroendocrine Federation from July 11-15th, 2010, at the Law Faculty, Rouen, France.

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Ein kurzgefasster Leitfaden zu den modernen Therapiestrategien bei Diabetes im Kindes- und Jugendalter. UEbersichtlich und auf dem neuesten Stand - fur alle medizinischen und nicht-medizinischen Profis, die wenig Zeit haben, die wissenschaftlichen Grundlagen bereits kennen und schnelle Orientierung benoetigen.

Aluminium is the most abundant metal ion in the biosphere and we are continuously exposed to it in our everyday life through food, beverages, pharmaceutical products, etc. This book is a current and comprehensive review of the biochemistry, metabolism and toxicity of aluminium undertaken by an international group of authors, many of whom are outstanding authorities in their respective fields. In contrast with previous books on this topic, much of the subject matter is unique, in that it is primarily directed at aluminium nutrition and toxicity in infants and children. This book covers many aspects of aluminium toxicity in infants including for instance the embryo-fetal as well as the neurodevelopmental effects of this element, contamination of pharmaceutical products, and individual sensitivity through vaccines using aluminium as an adjuvant.This book will be especially useful to paediatricians, paediatric nephrologists & neurologists, nutritionists, toxicologists, biochemical toxicologists and postgraduate students.

kurz - prazise - konkret

Diabetes die Volksseuche des 21. Jahrhunderts: Jeder 5. Patient in der Arztpraxis hat Diabetes.

- Diagnostik und Therapie praxisorientiert und kompakt
- Konkrete Therapieziele, neueste Richtwerte und Therapeutika
- Hilfreichen Leitfaden: Notfalle, perioperative/periinterventionelle Versorgung
- Tipps und Tricks vom erfahrenen, interdisziplinaren Diabetes-Team

Gepruft in der taglichen Routine

Nach den Leitlinien der Deutschen Diabetes-Gesellschaft (DDG)"

Enzymes are the astonishing, tiny molecular machines that make life possible. Each one of these small proteins speeds up a single chemical reaction inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that collectively we recognise as life, from making DNA to digesting food. This Very Short Introduction explains the why and the how of speeding up these reactions - catalysis - before going on to reveal how we have evolved these catalysts of such extraordinary power and exquisite selectivity. Paul Engel shows how X-ray crystallography has revealed the complex molecular shapes that allow enzymes to function at an extraordinarily sophisticated level. He also examines medical aspects of enzymes, both in the way faulty enzymes cause disease and in the way enzymes can be used for diagnosis and therapy. Finally, he looks at the many varied ways in which individual enzymes, taken out of their biological context, are used nowadays as tools - in washing powders, food production, waste treatment, and chemical synthesis. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas. Timely and up-to-date, it opens with a review of the historical aspects of prolactin research and a discussion of pituitary anatomy and physiology. Several chapters examine basic and translational aspects of prolactin physiology, focusing on recent developments and future directions. The main portion of the book is comprised of chapters presenting the clinical aspects of prolactin excess or deficiency, with particular emphasis placed on prolactin-secreting pituitary adenomas and co-secreting tumors. Concluding chapters address prolactin-secreting pituitary adenomas in special populations - women in the preconception period or during pregnancy, children and adolescents, and men - as well as plurihormonal and aggressive adenomas and carcinomas. Written and edited by experts in the field, Prolactin Disorders will be a ready reference for a diverse array of professionals, from basic scientists to clinical investigators and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology and neuro-oncology.

This practical book describes only neurometabolic hereditary diseases which have a specific treatment and encourages the general neurologist to think of the most common neurometabolic hereditary diseases, which he might have seen and never considered in the differential diagnosis. Information regarding how to deal with diseases with special therapy is provided (i.e. enzymatic replacement therapy in Fabry disease and Pompe disease), as is information on diseases which are not easily recognized (i.e. Niemann-Pick disease type C), and diseases with clinical features mimicking other common neurodegenrative diseases (i.e. Wilson's disease). Neurometabolic Hereditary Diseases is written with a clinical focus for adult neurologists working in general hospitals.

This new edition provides clinicians and trainees with the latest advances in the diagnosis and management of diabetes mellitus. Beginning with an overview of physiology, epidemiology, pathogenesis and classification, the next chapters discuss related issues such as nutrition, exercise and counselling. The following sections cover different aspects of the disease including emergency situations, therapeutic agents, and associated disorders including retinopathy, stroke, liver disease, and neuropathy. The final chapters examine diabetes in specific demographic groups such as in pregnancy, obesity, in the elderly and in childhood and adolescence. The eighth edition has been fully revised and includes new topics including new anti-diabetic drugs, recent clinical trials, and non-alcoholic fatty liver disease. The book is highly illustrated with clinical photographs, tables and boxes, and each chapter concludes with MCQs (Multiple Choice Questions) with answers, for self-assessment. Key points Eighth edition presenting latest advances in diagnosis and management of diabetes Fully revised, with many new topics added Features MCQs with answers for self-assessment Previous edition (9789351528531) published in 2015