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Central Regulation of Growth - Morphological & Functional Considerations (Hardcover)
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Central Regulation of Growth - Morphological & Functional Considerations (Hardcover)
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Somatic growth is a crucial component in the development of an
organism. Growth is manifested in many levels during an organisms
lifespan; rapid intrauterine growth is followed by extrauterine
development that subsides with age. The control of growth is
exerted via particularly complex and multifaceted mechanisms that
affect every cell of the body, regulating the balance between the
anabolic and catabolic processes, and it is intimately entwined
with almost every physiological function. The central component of
this regulatory system is the hypothalamo-hypophyseal axis that
controls not only all of the endocrine organs of the body, but also
regulates the growth of every cell via growth hormone (GH) release.
It would certainly exceed the scope of the present book to
summarize the growth-related complex peripheral actions of the
various hormonal systems of the hypothalamo-hypophyseal axis. GH
secretion is modulated primarily by the somatotropic axis, which is
one of the functional components of the hypothalamo-hypophyseal
axis and integrates the stimulatory and inhibitory actions of
growth hormone-releasing hormone (GHRH) and somatostatin upon GH
release, respectively. Therefore, in the present volume we attempt
to give an overview of the regulatory components of a somatotropic
axis with a special emphasis on the regulatory input provided by
hypothalamic hormonal and neurotransmitter/neuromodulator systems.
Since it is particularly complicated to extrapolate animal data to
human physiology, the authors focus on human results while animal
studies are detailed only if they provide a better understanding to
how growth is regulated in humans. This process has proven to be
difficult due to the scarcity of human studies in this field.
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