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Selenium - Its Molecular Biology and Role in Human Health (Hardcover)
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Selenium - Its Molecular Biology and Role in Human Health (Hardcover)
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As discussed in this book, a large body of evidence indicates that
selenium is a cancer chemopreventive agent. Further evidence points
to a role of this element in reducing viral expression, in
preventing heart disease, and other cardiovascular and muscle
disorders, and in delaying the progression of AIDS in HIV infected
patients. Selenium may also have a role in mammalian development,
in male fertility, in immune function and in slowing the aging
process. The mechanism by which selenium exerts its beneficial
effects on health may be through selenium-containing proteins.
Selenium is incorporated into protein as the amino acid
selenocysteine. Selenocysteine utilizes a specific tRNA, a specific
elongation factor, a specific set of signals, and the codeword,
UGA, for its cotranslational insertion into protein. It is indeed
the 21st naturally occurring amino acid to be incorporated into
protein and marks the first and only expansion of the genetic code
since the code was deciphered in the mid 1960s.
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