Conservation Physiology for the Anthropocene - A Systems Approach, Volume 39B in the Fish Physiology series, is a comprehensive synthesis related to the physiology of fish in the Anthropocene. This volume helps solve knowledge gaps by considering the many ways in which different physiological systems (e.g., sensory physiology, endocrine, cardio-respiratory, bioenergetics, water and ionic balance and homeostasis, locomotion/biomechanics, gene function) and physiological diversity are relevant to the management and conservation of fish and fisheries. Chapters in this release include Using physiology for recovering imperiled species - the Delta smelt, Conservation hatcheries - the Sturgeon story, Aquatic pollutants and stressors, and more. Other sections discuss Fisheries interactions in a multi-stressor world, Environmental change in riverine systems - Amazon basin stressors, Environmental change in lakes and wetlands - East African basin stressors, Coral reef fish in a multi-stressor world, Polar fish in a multi-stressor world, Physiology informs fisheries restoration and habitat management, A physiological perspective on fish passage and entrainment, Invasive species control and management - the sea lamprey story, and On the conservation physiology of fishes for tomorrow.

The series "Fish Physiology" recently celebrated its 50th Anniversary. In total, the editors of the series have produced a total of 47 books (several volumes have two books) that contain almost 500 chapters since the inaugural volume published in 1969. The content of the "Fish Physiology" volumes has evolved over time. The initial volumes were devoted to understanding the basic mechanisms and principles of fish physiology, with a focus on a few model species and some application to natural environmental conditions. Then, as the field better understood mechanisms, the approach was broadened to not only delve deeper into system physiology (e.g., chapters in early volumes were expanded to become books), but interspecific differences in physiology were explored, permitting a more evolutionary framework. Finally, as interspecific physiological mechanisms were further resolved, it became possible to discuss physiology in light of a changing world. Thus, physiology can now inform on conservation, sustainability and management, as exemplified with the most recent volumes. This anniversary issue celebrates the series by highlighting some of the very important early work in the field that was published in the Series. In particular, we wished to (re)introduce new researchers to this research that has stood the test of time and that shaped the field. Each re-published chapter is preceded by a short review written by experts in the field to provide an overview/introduction of each selected chapter, discuss what is particularly noteworthy or important in the particular chapter, and discuss why in their opinion this chapter has become a classic in its own right and how it has inspired the field of fish physiology today?

Fish Physiology, Volume 38 in this ongoing series, examines how the inherent potential of fish to express traits of economic value can be realized through aquaculture. Topics covered include the regulation of the reproductive cycle of captive fish, shifting carnivorous fish towards plant-based diets, defining the challenges, opportunities and optimal conditions for growth under intensive culture (including in Recirculating Aquaculture Systems), enhancing immune function and fish health during culture, identifying and managing maladaptive physiological responses to aquaculture stressors, establishing welfare guidelines for farmed fish, phenotypic and physiological responses to genetic modification, Zebrafish as a research tool, and the aquaculture of air-breathing fish.

The years 1900 to 1954 marked the transformation from an exotic, colonized "Far East" to a more autonomous, prominent "Asia Pacific". This anthology examines the grand strategies of great powers as they vied for influence and ultimately hegemony in the region. At the turn of the twentieth century, the main contestants included the venerable British Empire and the aspiring Japan and United States. The unwieldy leviathan of China, the European imperial holdings in Southeast Asia, and the expanses of the western Pacific emerged as battlegrounds in literal and geopolitical terms. Other less powerful nations, such as India, Burma, Australia, and French Indochina, also exercised agency in crafting grand strategies to further their interests and in their interactions with those great powers. Among the many factors affecting all nations invested in the Asia Pacific were such traditional elements as economics, military power, and diplomacy, as well as fluid traits like ideology, culture, and personality. The era saw the decline of British and European influence in the Asia Pacific, the rise and fall of Japanese imperialism, the emergence of American primacy, the ongoing struggle for independence in Southeast Asia, and China's resurrection as a contender for hegemony. Great powers shifted and so too did their grand strategies.

"Fish Physiology: Organic Chemical Toxicology of Fishes" discusses the different types of organic chemical contaminants and their respective toxic effects in fish. The book also covers the detection of dissolved organic compounds and methods to assess organic toxicity. Substances addressed in this book include organometallics, hydrocarbons, endocrine disrupting compounds (EDCs), insecticides, herbicides, and pharmaceuticals.

Fish are exposed to an ever-increasing array of organic chemicals that find their way into rivers and oceans. Some of these compounds are no longer being produced but nonetheless persist within the environment (persistent organic pollutants, or POPs). The exposure of fish to toxic organic compounds has potential impact on human, fish, and ecosystem health. Yet the regulations that govern environmental water quality vary worldwide, and compliance is never complete. This book provides a crucial resource on these issues for researchers in zoology, fish physiology, and related fields; applied researchers in environmental monitoring, conservation biology, and toxicology; and university-level students and instructors in these areas.
Organized by type of toxic organic chemicalsIncludes metals, POPs, EDCs, herbicides, insecticides, and pharmaceuticalsMeasures toxicity in a variety of ways aside from lethalityProbes the toxic effects of compound mixtures as well as single pollutants

The need for ion and water homeostasis is common to all life. For fish, ion and water homeostasis is an especially important challenge because they live in direct contact with water and because of the large variation in the salt content of natural waters (varying by over 5 orders of magnitude). Most fish are stenohaline and are unable to move between freshwater and seawater. Remarkably, some fishes are capable of life in both freshwater and seawater. These euryhaline fishes constitute an estimated 3 to 5% of all fish species. Euryhaline fishes represent some of the most iconic and interesting of all fish species, from salmon and sturgeon that make epic migrations to intertidal mudskippers that contend with daily salinity changes. With the advent of global climate change and increasing sea levels, understanding the environmental physiology of euryhaline species is critical for environmental management and any mitigative measures. This volume will provide the first integrative review of euryhalinity in fish. There is no other book that focuses on fish that have the capacity to move between freshwater and seawater. The different challenges of salt and water balance in different habitats have led to different physiological controls and regulation, which heretofore has not been reviewed in a single volume.
Collects and synthesizes the literature covering the state of knowledge of the physiology of euryhaline fish

Provides the foundational information needed for researchers from a variety of fields, including fish physiology, conservation and evolutionary biology, genomics, ecology, ecotoxicology, and comparative physiologyAll authors are the leading researchers and emerging leaders in their fields

"Homeostasis and Toxicology of Non-Essential Metals" synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Ag, Al, Cd, Pb, Hg, As, Sr, and U have no known nutritive function in fish at present, but are toxic at fairly low levels.

The companion volume, "Homeostasis and Toxicology of Essential Metals, " Volume 31A, covers metals that are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers.
All major essential metals of interest are covered in metal-specific chaptersEach metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metalA common format is featured throughout this two volume edition

"Homeostasis and Toxicology of Essential Metals" synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses.

The companion volume, "Homeostasis and Toxicology of Non-Essential Metals, " Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers.
All major essential metals of interest are covered in metal-specific chaptersEach metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metalA common format is featured throughout this two volume edition

"The" "Multifunctional Gut of Fish" provides a comprehensive synthesis and an integrative overview of the range of gut functions and their implications for organismal physiology. The highly diversified anatomy and functions of the gut, including nutrient uptake, immune barrier function, salt and water homeostasis and respiration, as well as neuroendocrine actions and control are covered in detail by leading authors. In addition, this volume explores the pronounced implications of gut function for whole animal integrative physiology and compensatory demands for non-gastrointestinal organs. As the first comprehensive reference to discuss the diverse morphological and functional adaptations of the gut, this volume provides an excellent resource for comparative physiologists, aquaculturists and biomedical researchers employing fish as model organisms for mammalian physiology.

Includes chapters dedicated to anatomical and functional features of the gastro-intestinal tract of fish as well as integrative aspects of gut organ function.

Includes in depth coverage of recently recognized implications of feeding on salt homeostasis and acid-base balance.

Provides syntheses of implications of gut function for homeostasis.

Essential text for those interested in the wide diversity of functions performed by the gut.

This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a "fully" sequenced genome, ii) rapid ( 3 month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics to assess gene function. Gene knockdown in embryos and the production of transgenic strains are now standard techniques being used to assess physiology. This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists and developmental biologists.

Key Features
* Integrates and synthesizes the biology of the zebrafish under one cover
* Features contributions from the leading researchers in their fields
* Reaches a wider audience of researchers and biologists with its broad inclusion of subjects relating to zebrafish physiology

The study of fish neuroendocrinology has had a significant impact on our general understanding of the functional roles and evolution of a variety of neurochemical messengers and systems. Not only do fish possess unique neuroendocrine features, they have also been and remain an important vertebrate models for the discovery of new neuropeptides. In the last fifty years, neuroendocrinologists have documented a complex and seemingly infinite number of interactions between hormones and nerve structures. Gradually emerging from this knowledge is an understanding of the specific neurohormonal pathways and the messengers responsible for maintaining homeostasis in an aquatic environment and for regulating the functional systems that allow for the highly diverse life histories and reproductive tactics of fish
Despite its recent growth, breadth and unique attributes, there is no single text covering the discipline of fish neuroendocrinology. In fact, other than a few mammalian neuroendocrinology textbooks, there is a serious lack of texts in comparative neuroendocrinology. Currently, information on the anatomical organization and function of the various neuroendocrine systems in fish is only available in original research papers and reviews.
By providing a current and comprehensive volume that highlights the specific properties of fish neuroendocrinology, this book will go beyond being the only reference text for fish neuroendocrinologists and will also serve comparative physiologists, endocrinologists, neuroanatomists and behaviourists interested in understanding the reciprocal actions between the nervous and endocrine systems.

* Highlights the specific properties of fish neuroendocrinology
* Emphasises the range and variety of interactions between neurobiology and endocrinology
* Discuses both anatomical and functional aspects of the Neuroendocrine system
* Also serves comparative physiologists, endocrinologists, neuroanatomists and behaviourists interested in understanding the reciprocal actions between the nervous and endocrine systems

Periods of environmental hypoxia (Low Oxygen Availability) are extremely common in aquatic systems due to both natural causes such as diurnal oscillations in algal respiration, seasonal flooding, stratification, under ice cover in lakes, and isolation of densely vegetated water bodies, as well as more recent anthropogenic causes (e.g. eutrophication). In view of this, it is perhaps not surprising that among all vertebrates, fish boast the largest number of hypoxia tolerant species; hypoxia has clearly played an important role in shaping the evolution of many unique adaptive strategies. These unique adaptive strategies either allow fish to maintain function at low oxygen levels, thus extending hypoxia tolerance limits, or permit them to defend against the metabolic consequences of oxygen levels that fall below a threshold where metabolic functions cannot be maintained.
The aim of this volume is two-fold. First, this book will review and synthesize the adaptive behavioural, morphological, physiological, biochemical, and molecular strategies used by fish to survive hypoxia exposure and place them within an environmental and ecological context. Second, through the development of a synthesis chapter this book will serve as the cornerstone for directing future research into the effects of hypoxia exposures on fish physiology and biochemistry.

Key Features
* The only single volume available to provide an in-depth discussion of the adaptations and responses of fish to environmental hypoxia.
* Reviews and synthesizes the adaptive behavioural, morphological, physiological, biochemical, and molecular strategies used by fish to survive hypoxia exposure.
* Includes discussion of the evolutionary and ecological consequences of hypoxia exposure in fish.

Conservation Physiology for the Anthropocene: A Systems Approach, Volume 39A in the Fish Physiology series, is a comprehensive synthesis on the physiology of fish in the Anthropocene. This volume closes the knowledge gap by considering the many ways in which different physiological systems (e.g., sensory physiology, endocrine, cardio-respiratory, bioenergetics, water and ionic balance and homeostasis, locomotion/biomechanics, gene function) and physiological diversity are relevant to management and conservation. As the world is changing, with a dire need to identify solutions to the many environmental problems facing wild fish populations, this book comprehensively covers conservation physiology and its future techniques. Conservation physiology reveals the many ways in which environmental change and human activities can negatively influence wild fish populations. These tactics inform new management and conservation activities and help create the necessary conditions for fish to thrive.

Volume 22 of the Fish Physiology Series is entirely devoted to fishes of high latitudes (Arctic and Antarctic). Three central themes comprise the book:
The uniqueness of the physiology of fishes that live in cold polar environments, a comparative analysis of physiological patterns exemplified by fishes that live poles apart and, how fishes differ from fishes living in more temperate and tropical habitats.
This book highlights the physiological adaptations that evolved to allow certain fish to exploit the frigid, yet productive, Arctic and Antarctic Oceans. The reader will explore what is known, as well as what remains undiscovered, concerning the fish indigenous to both polar regions. This will be of great interest to physiologists, ichthyologists, and comparative biologists researching low temperature biology, fishery scientists, faculty, graduate students
* Offers an comparative analysis of the arctic and antarctic polar marine environments
* Authors answer the question: What is special about the physiology of fish from the stenothermal Arctic and Antarctic environments?
* Includes nine descriptive chapters, 40 tables and over 80 figures

The deep ocean is home to some of the most unusual of all fishes. This book is the first Fish Physiology volume devoted to these bizarre undersea creatures. Practically every organ system is affected by the constraints imposed by benthic pressure, the absence of light, and the relatively scarce supply of both food and mates. Deep Sea Fishes demonstrates how these fishes living in extremely harsh conditions metabolize, behave, and evolve.

Leishmania parasites cause a diverse group of diseases endemic to many tropical and subtropical regions of the world. This volume seeks to bring together recent research on cell and molecular biology of Leishmania with chapters on the host response to infection, the current epidemiology of leishmaniasis, explanations of the many different species, vector control, and strategies for vaccine development and drug treatment. Leishmania, volume four of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Carbon Dioxide, Volume 37 in the Fish Physiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Historic, current-day and future CO2 environments and their dynamics in marine and freshwater ecosystems, CO2 sensing, Acid-base physiology and CO2 homeostasis: regulation and compensation, CO2 and calcification processes in fish, The physiology of behavioral impacts of high CO2, Effects of high CO2 on metabolic rates, aerobic scope and swimming performance, Internal spatial and temporal CO2 effects: feeding and alkaline tide, O2 in aquaculture: CO2 dynamics and fish health, and much more.

Fish Physiology: Physiology of Elasmobranch Fishes, Volume 34B is a useful reference for fish physiologists, biologists, ecologists, and conservation biologists. Following an increase in research on elasmobranchs due to the plight of sharks in today's oceans, this volume compares elasmobranchs to other groups of fish, highlights areas of interest for future research, and offers perspective on future problems. Covering measurements and lab-and-field based studies of large pelagic sharks, this volume is a natural addition to the renowned Fish Physiology series.

Fish Physiology: Physiology of Elasmobranch Fishes, Volume 34A is a useful reference for fish physiologists, biologists, ecologists, and conservation biologists. Following an increase in research on elasmobranchs due to the plight of sharks in today's oceans, this volume compares elasmobranchs to other groups of fish, highlights areas of interest for future research, and offers perspective on future problems. Covering measurements and lab-and-field based studies of large pelagic sharks, this volume is a natural addition to the renowned Fish Physiology series.

This book provides a comprehensive collection of timely reviews of our current understanding of the fundamental principles of nitrogen metabolism and excretion in fish. Emphasis is placed on critical assessment of how new studies impact these topics, and the articles reflect the diversity of current research approaches.

In 1945, a mysterious Nazi secret weapons project code-named 'The Bell' left its underground bunker in lower Silesia, along with its project documentation, and the 4-star SS general Hans Kammler. Taken aboard a massive six engine Junkers 390 ultra-long range aircraft, The Bell, Kammler, and all project records disappeared completely, along with the gigantic Junkers 390 carrying them. It has been speculated that it flew to Argentina. As a prelude to this disappearing act, the SS murdered most of the scientists and technicians involved with the project, a secret weapon that, according to one German Nobel prize-winning physicist, was given a classification of decisive for the war - the highest security classification. Offered here is a range of exotic technologies the Nazis researched, and challenges to the conventional views of the end of World War Two, the Roswell incident, and the beginning of MAJIC-12, the government's alleged secret team of UFO investigators.

The Cardiovascular System: Phenotypic and Physiological Responses, Volume 37, part of a two-volume set, provides comprehensive coverage of the current state of knowledge in this very active and growing field of research, also highlighting the tremendous diversity in cardiovascular morphology and function among the various fish taxa and the anatomical and physiological plasticity shown by this system when faced with various abiotic and biotic challenges. Specific chapters in this updated book include Research Technologies/Methodology for Studying Fish Cardiovascular Function, Cardiovascular Development in Embryonic and Larval Fishes, Cardiovascular Responses to Limiting Oxygen Levels, and Temperature and the Cardiovascular System. The book's chapters integrate molecular and cellular data with the growing body of knowledge on heart and in vivo cardiovascular function, and as a result, provide insights into some of the most interesting, and important, questions that still need to be answered in this field.

Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.