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4 matches in All Departments
Leukocyte adhesion molecules have been the subject of intense basic
and preclinical research. Results from clinical trials obtained
sofar with antibodies directed towards these surface proteins offer
promise for the prevention of graft rejection and effective
treatment of acute and chronic inflammatory disease. This volume
presents a comprehensive review of contemporary research on the
structure, function and regulation of leukocyte adhesion molecules
and their ligands, from the molecular to the clinical level. The
blend of basic science and clinical applications presented in
Structure, Function and Regulation of Molecules Involved in
Leukocyte Adhesion provides clear evidence of the biological
importance of cell-cell interactions and the many potential
clinical dividends afforded by understanding the molecular basis of
cell adhesion. It will appeal to a broad range of readers in
immunology and cell biology.
The immune system has been known to be capable of distinguishing
self from non-self since the pioneering work of Paul Erhlich more
than a century ago. Originally described in experiments studying
blood transfusion comp- ibility, the principle of "horror
autotoxicus" is still valid, although today the phenomenon is
usually described in terms of tolerance or ignorance. A great deal
has been learned about the various processes preventing
self-reactivity normally. These include processes that operate
during immune cell ontogeny and subsequently on reactivity of
mature lymphocytes in the periphery. They encompass mechanisms that
are intrinsic to potentially reactive lymphocytes and can result in
central or peripheral deletion or the alteration of functional
potential. In addition, there are in?uences that are extrinsic to
potentially auto-reactive lymphocytes, including the function of
regulatory cells, d- ferentiation state of antigen-presenting
cells, availability of self-antigen, the cytokine and chemokine
milieu, as well as the traf?cking patterns involved in generating
productive immune interactions. It is clear that the immune system
devotes a considerable effort to the avoidance of the development
of potentially pathogenic self-reactivity. Despite this, the
development of self-reactivity is relatively common. - though the
development of autoimmune disease is less frequent, autoimmune
diseases, such as rheumatoid arthritis, multiple sclerosis,
systemic lupus e- thematosus, psoriasis, thyroiditis, and
myasthenia gravis, are all too common, and can cause considerable
morbidity and even mortality.
The immune system has been known to be capable of distinguishing
self from non-self since the pioneering work of Paul Erhlich more
than a century ago. Originally described in experiments studying
blood transfusion comp- ibility, the principle of "horror
autotoxicus" is still valid, although today the phenomenon is
usually described in terms of tolerance or ignorance. A great deal
has been learned about the various processes preventing
self-reactivity normally. These include processes that operate
during immune cell ontogeny and subsequently on reactivity of
mature lymphocytes in the periphery. They encompass mechanisms that
are intrinsic to potentially reactive lymphocytes and can result in
central or peripheral deletion or the alteration of functional
potential. In addition, there are in?uences that are extrinsic to
potentially auto-reactive lymphocytes, including the function of
regulatory cells, d- ferentiation state of antigen-presenting
cells, availability of self-antigen, the cytokine and chemokine
milieu, as well as the traf?cking patterns involved in generating
productive immune interactions. It is clear that the immune system
devotes a considerable effort to the avoidance of the development
of potentially pathogenic self-reactivity. Despite this, the
development of self-reactivity is relatively common. - though the
development of autoimmune disease is less frequent, autoimmune
diseases, such as rheumatoid arthritis, multiple sclerosis,
systemic lupus e- thematosus, psoriasis, thyroiditis, and
myasthenia gravis, are all too common, and can cause considerable
morbidity and even mortality.
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Gout (Paperback)
Naomi Schlesinger, Peter E. Lipsky
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R2,090
Discovery Miles 20 900
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Ships in 12 - 17 working days
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Concise and clinically focused, Gout, by Drs. Naomi Schlesinger and
Peter E. Lipsky, provides a one-stop overview of recent
developments regarding this common form of inflammatory arthritis.
Impacting an estimated 8.3 million people in the U.S. alone, gout
is seen frequently by both primary care physicians as well as
rheumatologists. This resource provides detailed coverage of the
epidemiology, causes, diagnosis, management, and treatment of
patients with both acute and chronic gout. Addresses key topics
such as genetics, hyperuricemia, comorbidities of gout, treatment
guidelines for acute and chronic gout, classification and
diagnosis, and imaging. Discusses future outlooks for improving
pharmacological and nonpharmacological treatment options, including
an overview of drugs in the pipeline. Consolidates today's
available information on this timely topic into one convenient
resource.
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