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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Current Concepts in Autoimmunity and Chronic Inflammation (Paperback, Softcover reprint of hardcover 1st ed. 2006)
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Current Concepts in Autoimmunity and Chronic Inflammation (Paperback, Softcover reprint of hardcover 1st ed. 2006)
Series: Current Topics in Microbiology and Immunology, 305
Expected to ship within 9 - 17 working days
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The immune system has been known to be capable of distinguishing
self from non-self since the pioneering work of Paul Erhlich more
than a century ago. Originally described in experiments studying
blood transfusion comp- ibility, the principle of "horror
autotoxicus" is still valid, although today the phenomenon is
usually described in terms of tolerance or ignorance. A great deal
has been learned about the various processes preventing
self-reactivity normally. These include processes that operate
during immune cell ontogeny and subsequently on reactivity of
mature lymphocytes in the periphery. They encompass mechanisms that
are intrinsic to potentially reactive lymphocytes and can result in
central or peripheral deletion or the alteration of functional
potential. In addition, there are in?uences that are extrinsic to
potentially auto-reactive lymphocytes, including the function of
regulatory cells, d- ferentiation state of antigen-presenting
cells, availability of self-antigen, the cytokine and chemokine
milieu, as well as the traf?cking patterns involved in generating
productive immune interactions. It is clear that the immune system
devotes a considerable effort to the avoidance of the development
of potentially pathogenic self-reactivity. Despite this, the
development of self-reactivity is relatively common. - though the
development of autoimmune disease is less frequent, autoimmune
diseases, such as rheumatoid arthritis, multiple sclerosis,
systemic lupus e- thematosus, psoriasis, thyroiditis, and
myasthenia gravis, are all too common, and can cause considerable
morbidity and even mortality.
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