This book presents a collection of articles on various aspects of current research on aging. These include model systems, cellular, biochemical and molecular aspects of experimental aging research, as well as selected intervention studies on age-related diseases. Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity. Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Are there medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age. Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.

This book provides an upto date information on metric, connection and curva ture symmetries used in geometry and physics. More specifically, we present the characterizations and classifications of Riemannian and Lorentzian manifolds (in particular, the spacetimes of general relativity) admitting metric (i.e., Killing, ho mothetic and conformal), connection (i.e., affine conformal and projective) and curvature symmetries. Our approach, in this book, has the following outstanding features: (a) It is the first-ever attempt of a comprehensive collection of the works of a very large number of researchers on all the above mentioned symmetries. (b) We have aimed at bringing together the researchers interested in differential geometry and the mathematical physics of general relativity by giving an invariant as well as the index form of the main formulas and results. (c) Attempt has been made to support several main mathematical results by citing physical example(s) as applied to general relativity. (d) Overall the presentation is self contained, fairly accessible and in some special cases supported by an extensive list of cited references. (e) The material covered should stimulate future research on symmetries. Chapters 1 and 2 contain most of the prerequisites for reading the rest of the book. We present the language of semi-Euclidean spaces, manifolds, their tensor calculus; geometry of null curves, non-degenerate and degenerate (light like) hypersurfaces. All this is described in invariant as well as the index form."

This multi-chapter book focuses on one of the hottest topics in ageing research - the role of hormones in health and longevity, offering a comprehensive and up-to-date overview of their mechanistic roles in health, ageing and longevity. Hormones are an excellent system of communication between cells and tissues within an organism, and they coordinate a wide range of processes in biological systems, including neuroendocrine and immunological controls. The book offers insights into the latest significant advances in our understanding of the mechanisms of hormonal signaling that control a variety of processes involved in development and ageing. It is divided into four parts: Part I includes a review of the hundred-year history of hormones by the illustrious hormone biochemist Dr. J.R. Tata. Part II presents various chapters on the hormones involved in growth, stress and metabolism, while Part III addresses the hormones controlling cognition and rhythms in ageing processes. Lastly, Part IV discusses the hormones affecting reproduction, immunity and life span. It also explores the use of hormones as pharmaceuticals to maintain health in the elderly. It is a valuable resource for those working in the area of hormone signaling in general and in the field of ageing research in particular.

The continued prevalence of major incidents (most recently the 2010 BP Gulf of Mexico Oil Spill) and preponderance of workplace fatalities and injuries as well as Process Safety Management (PSM) Incidents, globally, begs the question: why do incidents continue to occur in today's technologically advanced era? More importantly, with 80-85 percent of incidents being repeated, the more obvious questions are: Why do organizations fail to learn from prior incidents internal to the business? Why do organizations fail to learn from their peers and other same industry players? Why do organizations fail to learn from the incidents and experiences of other industries? Process Safety Management: Leveraging Networks and Communities of Practice for Continuous Improvement provides a road map organizations can use to identify and setup critical networks for preventing catastrophic incidents and for sharing knowledge in an organized manner within the organization to enhance business performance. The book helps organizations establish centers of excellence by activating networks for generating best practices and practical solutions to workplace business, and safety challenges. The book covers the full range of activation of networks including identifying members, defining goals and objectives, and prioritizing work through leadership and stewardship of networks. It addresses all elements of effective safety management and includes simple, easy-to-follow processes that bring about lasting changes to workplace safety. It also highlights the health and safety needs of both Generation X and Generation Y who currently inherit the workplace but are very different in learning behaviors and experience levels. In a thin margins business environment characterized by scarce resources, operational discipline and excellence drives stakeholder confidence and corporate performance. Detailing the practical application of tested principles and practices, this book provides a simple path forward for organizations to recognize the benefits of networks and to proactively establish and support them within organizations to generate continuous and sustained improvement in work practices, procedures, and business performance.

This book provides an upto date information on metric, connection and curva ture symmetries used in geometry and physics. More specifically, we present the characterizations and classifications of Riemannian and Lorentzian manifolds (in particular, the spacetimes of general relativity) admitting metric (i.e., Killing, ho mothetic and conformal), connection (i.e., affine conformal and projective) and curvature symmetries. Our approach, in this book, has the following outstanding features: (a) It is the first-ever attempt of a comprehensive collection of the works of a very large number of researchers on all the above mentioned symmetries. (b) We have aimed at bringing together the researchers interested in differential geometry and the mathematical physics of general relativity by giving an invariant as well as the index form of the main formulas and results. (c) Attempt has been made to support several main mathematical results by citing physical example(s) as applied to general relativity. (d) Overall the presentation is self contained, fairly accessible and in some special cases supported by an extensive list of cited references. (e) The material covered should stimulate future research on symmetries. Chapters 1 and 2 contain most of the prerequisites for reading the rest of the book. We present the language of semi-Euclidean spaces, manifolds, their tensor calculus; geometry of null curves, non-degenerate and degenerate (light like) hypersurfaces. All this is described in invariant as well as the index form.

As corruption continues to be a persistent problem in India, concerned citizens believe empowered police agencies independent of political control are effective ways to deal with corrupt officials and politicians. What is corruption and how is it facilitated? What are the appropriate agencies to combat corruption professionally in India? Why are these not effective in deterring corrupt practices? Are the alternative solutions to tackle corruption successful? This book seeks to engage with these questions, discuss and analyze them, and conduct a thorough analysis of law, bureaucratic organizations, official data, case studies and comparative international institutions. It analyzes vast data to argue that a corrupt state only maintains the facade of rule of law but will not permit any inquiry beyond that of individual deviance. Using criminological perspectives, it presents a novel mechanism, the 'Doctrine of Good Housekeeping', for public officials to combat and prevent corruption within their own institutions.